Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Study of Relationship between Metabolic Syndrome and Bone Mineral Density on Post Menopausal Chronic Low Back Pain Patients Under Oriental Medicine Treatment

요통으로 한방치료중인 폐경 후 여성의 대사증후군 요인이 골밀도에 미치는 영향에 관한 연구

  • Lee, Jong Deok (Department of Radiology, College of Korean Medicine, Wonkwang University) ;
  • Kim, Dong Woung (Department of Radiology, College of Korean Medicine, Wonkwang University)
  • 이종덕 (원광대학교 광주한방병원 영상의학과) ;
  • 김동웅 (원광대학교 광주한방병원 영상의학과)
  • Received : 2013.01.14
  • Accepted : 2013.02.21
  • Published : 2013.02.25
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed from April, 2007 to August, 2012 with female patients who were being treated for and suffering from chronic lumbar pain for periods of 6 months and over. The 53 female patients were diagnosed with osteoporosis by having a T-Score of <-2.5 in a bone mineral density(BMD), as well as showing signs of metabolic syndrome. This was deduced by taking measurements of blood pressure, carrying out blood-chemical examinations and physical measurements such as weight, height, waist measurement and body mass index(BMI). After 5 minutes rest, the patient's blood pressure, height and weight were measured. BMI was calculated using the equation BMI = weight (Kg)/height ($m^2$). The patients had their blood taken in a fasted state(more than 12hours), the fasting blood sugar, total cholesterol, triglyceride, HDL-cholesterol were measured. The average BMD and T-score were calculated by measuring BMD(mg/cc) of L1-L3 using QCT. In a correlation analysis of the physical examinations, clinical character of metabolic syndrome and T-score, the result showed that age and T-score had a negative correlation(r=-0.699, p<0.01) as did triglyceride and T-score (r=-0.047, p<0.01), where as weight(r=0.239, p<0.05) and height(r-=0.329, p<0.01) and T-score had a positive correlation. There was no significant correlation with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score. This study showed that there are significant correlations with age, weight, height and T-score. But there are no significant correlations with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score and that these did not influence bone density. Further research with more subjects is required to determine whether there is a correlation of clinical character of metabolic syndrome and T-score.

Keywords

References

  1. Korean Society of Bone Metabolism, Physician's guide for diagnosis and treatment of osteoporosis., Seoul, The Korean Society of Bone Metabolism, 2010.
  2. Takuo Fujita: Recent advances on osteoporosis, The Journal of Korean Society of Endocrinology, 5(2):92-100, 1990.
  3. Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med, 94: 646-650, 1993. https://doi.org/10.1016/0002-9343(93)90218-E
  4. WHO(World Health Organization). Report of a WHO consultation of metabolic syndrome in definition, diagnosis, and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus. World health Organization, Department of Noncommunicable Disease Surveillance, Geneva, 1999.
  5. 박혜순. 한국인에서의 대사증후군의 역학. 대한비만학회지 11: 203-211, 2002.
  6. Executive Summary of the Third report of the National Cholesterol Education Program(NCEP) Expert Panel on Detection, Evaluation, and treatment of high Blood cholesterol in Adults(Adult Treatment Pannel III). JAMA 28: 2486-2497, 2001.
  7. Baldini, V., Mastropasqua, M., Francucci, C. M., D'Erasmo, E. Cardiovascular disease and osteoporosis. Journal of Endocrinological Investigation, 28: 69-72, 2005.
  8. Yamaguchi T., Sugimoto T., Yano S., Yamauchi M., Sowa H., Chen Q., Chihara K. Plasma lipids and osteoporosis in postmenopausal women. a pilot study. J Am Geriatr Soc 51: 1510-1511, 2003. https://doi.org/10.1046/j.1532-5415.2003.514847.x
  9. Andrea Poli., Fiorenza Bruschi., Bruno Cesana., Monica Rossi., Rodolfo Paoletti., Pier Giorgio Crosignani. Plasma Low-Density Lipoprotein Cholesterol and Bone Mass Densitometry in Postmenopausal Women. Obstet Gynecol 102: 922-926, 2003. https://doi.org/10.1016/j.obstetgynecol.2003.07.004
  10. http://www.knhanes.cdk.go.kr
  11. The Fourth Korea National Health and Nutrition Examination Survery (KNHANES IV-2), Korea Centers for Disease Control and Prevention.
  12. Ford, E.S., Giles, W.H., Dietz, W.H. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287: 356-359, 2002. https://doi.org/10.1001/jama.287.3.356
  13. Park, Y.W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M.R., Heymsfield, S.B. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 163: 427-436, 2003. https://doi.org/10.1001/archinte.163.4.427
  14. Kim, S.M., Kim, S.H., Lee, J.R., Jee, B.C., Ku, S.Y., Suh, C.S. The effects of hormone therapy on metabolic risk factors in postmenopausal Korean women. Climacteric 14: 66-74, 2011. https://doi.org/10.3109/13697137.2010.498593
  15. NIH Consensus Development Panel. Osteoporosis prevention, diagnosis, and therapy. JAMA 285: 785-795, 2001. https://doi.org/10.1001/jama.285.6.785
  16. Claus Christiansen: The third symposium for osteoporosis in seoul, Cheil general hospital, pp 43-45, 1995.
  17. Carranza Lira, S., Rosas, N., Murillo, A., Martinez, N., Santos, J. Osteoporosis in postmenopausal women(Mexico City): 1. risk factor. Int J Fertil. Women Med.47(1), pp 22-25, 2002.
  18. 조수현, 조삼현, 황윤영, 문형, 이재억, 조석신. 폐경기 여성의 혈정 지질농도와 요추골밀도의 상관관계. 대한산부인과학회지 37(6):1175-1180, 1994.
  19. Ettinger, B. Prevention of osteoporosis: Treatment of estradiol deficiency. Obstet Gynecol 72: 125, 1988.
  20. Schindler, A.E., Ebert, A., Friedrich, E. Conversion of androstendione to estron by human fat tissue. J Clin Endocrinol Metab 35: 327, 2001.
  21. Truscott, J.G., Oldroyd, B., Simpson, M. Variation in lumbar spine and femoral neck bone mineral measured by dual energy x-ray absorption: a study of 329 normal women. Br J Rad 66: 514, 1993. https://doi.org/10.1259/0007-1285-66-786-514
  22. Young, E.A. Nutrition, aging and the aged. Med Clin North AM 67: 295, 1983. https://doi.org/10.1016/S0025-7125(16)31205-6
  23. Lirani-Galvao, A.P.R., Lazaretti-Castro, M. Physical approach for prevention and treatment of osteoporosis. Arquivos Brasileiros de Endocrinol & Metabologia, 54(2):171-178, 2010. https://doi.org/10.1590/S0004-27302010000200013
  24. Stolk, R.P., Hoes, A.W., Pols, H.A., Hofman, A., DeJong, P.t., Lamberts, S.W., Grobbee, D.E. Insulin, hypertension and antihypertensitive drugs in elderly patients. J. Hypertens. 14(2):234-242, 1996.
  25. Perez-Castrillon, N.L., Justo, I., Silva, J., Sanz, A., Igea, R., Escudero, P., Pueyo, C., Diaz, C., Hernndez, G., Due as, A. Bone mass and bone modelling markers in hypertensive postmenopausal women. J Hum Hypertens, 17(2):107-110, 2003. https://doi.org/10.1038/sj.jhh.1001520
  26. Larijani. B., Bekheirnia, M.R., Soltani. A., Khalili-Far. A., Adibi. H., Jalili R.B. Bone mineral density is related to blood pressure in men. Am J Hum Biol, 16(2):63-73, 2004.
  27. Grobbee, D.E., Hackeng, W.H.L., Birkenhager, J.C., Hofman, A. Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure. Br. Med J. 296(6625):814-816, 1988. https://doi.org/10.1136/bmj.296.6625.814
  28. L.H. Cui., M.H. Shin., E.K. Chung. Association between Bone Mineral Densities and Serum Lipid Profiles of Pre and Post-Menopausal Women in South Korea, Osteoporosis Int. 16: 1975-1981, 2005. https://doi.org/10.1007/s00198-005-1977-2
  29. D'Amelio, P., Pescarmona, G.P., Gariboldi, A., Isaia, G.C. High Density Lipoproteins(HDL) in Women with Postmenopausal Osteoporosis : A Preliminary Study, Menopause, 8: 429-432, 2001. https://doi.org/10.1097/00042192-200111000-00008
  30. Poli, A., Bruschi, F., Cesana, B., Rossi, M., Paoletti, R., Crosignani, P.G. Plasma Low-Density Lipoprotein Cholesterol and Bone Mass Densitometry in Postmenopausal Women, Obster Gynecol, 102: 922-926, 2003. https://doi.org/10.1016/j.obstetgynecol.2003.07.004