Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster

  • Received : 2013.03.25
  • Accepted : 2013.05.02
  • Published : 2013.05.31
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Abstract

Aging is the single most important risk factor that increases susceptibility to many forms of diseases. As such, much effort has been put forward to elucidate the mechanisms behind the processes of aging and to discover novel compounds that retain anti-aging activities. Korean red ginseng has been used for a variety of medical purposes in eastern countries for several thousands of years. It has been shown that Korean red ginseng affects a number of biological activities including, but not limited to, anti-inflammatory, anti-oxidative and anti-diabetic pathways. However, few studies have been performed to evaluate its anti-aging effects with an in vivo system. Here Drosophila melanogaster as an in vivo model organism demonstrates that Korean red ginseng tonic extends lifespan, increases resistance to starvation stress and prevents weight gain. This data suggest that Korean red ginseng may regulate organisms' metabolism in favor of extending lifespan.

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References

  1. Bae, E. A., Han, M. J., Shin, Y. W. and Kim, D. H. (2006) Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol. Pharm. Bull. 29, 1862-1867. https://doi.org/10.1248/bpb.29.1862
  2. Fontana, L., Partridge, L. and Longo, V. D. (2010) Extending healthy life span--from yeast to humans. Science 328, 321-326. https://doi.org/10.1126/science.1172539
  3. Giannakou, M. E. and Partridge, L. (2007) Role of insulin-like signalling in Drosophila lifespan. Trends Biochem. Sci. 32, 180-188. https://doi.org/10.1016/j.tibs.2007.02.007
  4. Gunasekaran, U. and Gannon, M. (2011) Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) 3, 565-575.
  5. Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A. and Evans, D. A. (2003) Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol. 60, 1119-1122. https://doi.org/10.1001/archneur.60.8.1119
  6. Helfand, S. L. and Rogina, B. (2003) From genes to aging in Drosophila. Adv. Genet. 49, 67-109. https://doi.org/10.1016/S0065-2660(03)01002-2
  7. Ho, Y. L., Li, K. C., Chao, W., Chang, Y. S. and Huang, G. J. (2012) Korean red ginseng suppresses metastasis of human hepatoma SK-Hep1 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen activator. Evid. Based Complement. Alternat. Med. 2012, 965846.
  8. Hong, Y. J., Kim, N., Lee, K., Hee Sonn, C., Eun Lee, J., Tae Kim, S., Ho Baeg, I. and Lee, K. M. (2012) Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments. J. Ethnopharmacol. 144, 225-233. https://doi.org/10.1016/j.jep.2012.08.009
  9. Johnson, S. C., Rabinovitch, P. S. and Kaeberlein, M. (2013) mTOR is a key modulator of ageing and age-related disease. Nature 493, 338-345. https://doi.org/10.1038/nature11861
  10. Kang, T. H., Park, H. M., Kim, Y. B., Kim, H., Kim, N., Do, J. H., Kang, C., Cho, Y. and Kim, S. Y. (2009) Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J. Ethnopharmacol. 123, 446-451. https://doi.org/10.1016/j.jep.2009.03.022
  11. Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V. and Benzer, S. (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885-890. https://doi.org/10.1016/j.cub.2004.03.059
  12. Katewa, S. D., Demontis, F., Kolipinski, M., Hubbard, A., Gill, M. S., Perrimon, N., Melov, S. and Kapahi, P. (2012) Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 16, 97-103. https://doi.org/10.1016/j.cmet.2012.06.005
  13. Katewa, S. D. and Kapahi, P. (2011) Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp. Gerontol. 46, 382-390. https://doi.org/10.1016/j.exger.2010.11.036
  14. Kennedy, S. R., Loeb, L. A. and Herr, A. J. (2012) Somatic mutations in aging, cancer and neurodegeneration. Mech. Ageing Dev. 133, 118-126. https://doi.org/10.1016/j.mad.2011.10.009
  15. Lee, H., Park, D. and Yoon, M. (2013) Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat dietinduced obese C57BL/6J mice. Food Chem. Toxicol. 53, 402-408. https://doi.org/10.1016/j.fct.2012.11.052
  16. Mackay, T. F. and Anholt, R. R. (2006) Of fl ies and man: Drosophila as a model for human complex traits. Annu. Rev. Genomics Hum. Genet. 7, 339-367. https://doi.org/10.1146/annurev.genom.7.080505.115758
  17. Oh, J., Lee, H., Park, D., Ahn, J., Shin, S. S. and Yoon, M. (2012) Ginseng and its active components ginsenosides inhibit adipogenesis in 3T3-L1 cells by regulating MMP-2 and MMP-9. Evid. Based Complement. Alternat. Med. 2012, 265023.
  18. Partridge, L., Alic, N., Bjedov, I. and Piper, M. D. (2011) Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp. Gerontol. 46, 376-381. https://doi.org/10.1016/j.exger.2010.09.003
  19. Partridge, L. and Barton, N. H. (1993) Evolution of aging: testing the theory using Drosophila. Genetica 91, 89-98. https://doi.org/10.1007/BF01435990
  20. Partridge, L., Piper, M. D. and Mair, W. (2005) Dietary restriction in Drosophila. Mech. Ageing Dev. 126, 938-950. https://doi.org/10.1016/j.mad.2005.03.023
  21. Piper, M. D. and Bartke, A. (2008) Diet and aging. Cell Metab. 8, 99-104. https://doi.org/10.1016/j.cmet.2008.06.012
  22. Piper, M. D., Skorupa, D. and Partridge, L. (2005) Diet, metabolism and lifespan in Drosophila. Exp. Gerontol. 40, 857-862. https://doi.org/10.1016/j.exger.2005.06.013
  23. Ramesh, T., Kim, S. W., Hwang, S. Y., Sohn, S. H., Yoo, S. K. and Kim, S. K. (2012) Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats. Nutr. Res. 32, 718-726. https://doi.org/10.1016/j.nutres.2012.08.005
  24. Tatar, M. (2007) Diet restriction in Drosophila melanogaster. Design and analysis. Interdiscip. Top. Gerontol. 35, 115-136.
  25. Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M. C., Lu, T. A., Benzer, S. and Kapahi, P. (2009) 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139, 149-160. https://doi.org/10.1016/j.cell.2009.07.034

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