Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Korean Herbal Medicines with Inhibitory Effect on Aldose Reductase (VIII)

한국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VIII)

  • Lee, Yun Mi (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Young Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Joo Hwan (Department of Life Science, Gachon University) ;
  • Kim, Jin Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 이윤미 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김영숙 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김주환 (가천대학교 생명과학과) ;
  • 김진숙 (한국한의학연구원 한약연구본부 한의신약연구그룹)
  • Received : 2013.03.06
  • Accepted : 2013.04.09
  • Published : 2013.06.30
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Abstract

Aldose reductase (AR) plays a central role in the development of the diabetic complications. Eighty one Korean herbal medicines have been investigated for inhibitory activities on AR. Among them, fourteen herbal medicines exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG) as positive control. Particularly, Xanthium strumarium (fruit, whole plant), Ilex cornuta (stem and leaf), Vitex rotundifolia(stem), Sophora flavescens (whole plant), Platycarya stobilacea (flower) showed two times more potent inhibitory activity than 3,3-tetramethyleneglutaric acid (TMG).

Keywords

References

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