Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (VII)

중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VII)

  • Lee, Yun Mi (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Young Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Joo Hwan (Department of Life Science, Gachon University) ;
  • Kim, Jin Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 이윤미 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김영숙 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김주환 (가천대학교 생명과학과) ;
  • 김진숙 (한국한의학연구원 한약연구본부 한의신약연구그룹)
  • Received : 2013.03.06
  • Accepted : 2013.04.09
  • Published : 2013.06.30
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Abstract

Aldose reductase (AR) has been shown to play an important role in the development of the diabetic complications. To discover novel treatments for diabetic complications from natural sources, 59 Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, 10 herbal medicines, Catalpa fargesii (stem and leaf), Saussurea Laniceps(whole plant), Alnus nepalensis(stem and leaf), Swertia macrosperma (whole plant), Woodfordia fruticosa (stem and leaf), Elsholtzia bodinieri (whole plant), Elsholtzia fruticosa (whole plant), Rosa multiflora (fruit), Nardostachys chinensis (whole plant), Eurya groffii (stem and leaf) exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG) as positive control. Particularly, 4 herbal medicines, C. fargesii (stem and leaf), S. Laniceps (whole plant), A. nepalensis (stem and leaf), S. macrosperma (whole plant) showed two times more potent inhibitory activity than TMG ($5.37{\mu}g/ml$).

Keywords

References

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