Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

A New Triterpenoid Saponin from Pulsatilla cernua

  • Fan, Wenhao (Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University) ;
  • Liu, Jianyu (Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University) ;
  • Gong, Yixia (Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University) ;
  • Ma, Jing (Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University) ;
  • Zhou, Nan (Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University) ;
  • Xu, Yongnan (Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University)
  • Received : 2013.05.18
  • Accepted : 2013.06.14
  • Published : 2013.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

A new oleanane-type triterpenoid saponin together with six known saponins were isolated from the roots of Pulsatilla cernua. Their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Compounds 1 and 6 are reported from this genus for the first time.

Keywords

References

  1. Bang, S.-C., Lee, J.-H., Song, G.-Y., Kim, D.-H., Yoon, M.-Y., and Ahn, B.-Z., Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. Chem. Pharm. Bull. 53, 1451-1454 (2005a). https://doi.org/10.1248/cpb.53.1451
  2. Bang, S.-C., Kim, Y., Lee, J.-H., and Ahn, B.-Z., Triterpenoid saponins from the roots of Pulsatilla koreana. J. Nat. Prod. 68, 268-272 (2005b). https://doi.org/10.1021/np049813h
  3. Fu, Y.-M., Chen, H., Liu, D.-L., and Zhang, Z.-M., Study on the chemical components of Pulsatilla cernua. Chin. Tradit. Herbal Drugs 39, 26-29 (2008).
  4. Kang, S.-S., Saponins from the roots of Pulsatilla koreana. Arch. Pharm. Res. 12, 42-47 (1989). https://doi.org/10.1007/BF02855745
  5. Kizu, H., Kitayama, S., Nakatani, F., Tomimori, T., and Namba, T., Studies on Nepalese Crude Drugs. III. On the saponins of Hedera nepalensis K. KOCH. Chem.Pharm.Bull, 33, 3324-3329 (1985). https://doi.org/10.1248/cpb.33.3324
  6. Li, X.-C, Wang, D.-Z., Wu, S.-G., and Yang, C.-R., Triterpenond saponins from Pulsatilla koreana. Phytochemistry 29, 595-599 (1990). https://doi.org/10.1016/0031-9422(90)85123-W
  7. Liu, J.-Y., Guan, Y.-L., Zou, L.-B., Gong, Y.-X., Hua, H.-M., Xu, Y.-N., Zhang, H., Yu, Z.-G., and Fan, W.-H., Saponins with neuroprotective effects from the roots of Pulsatilla cernua. Molecules 17, 5520-5531 (2012). https://doi.org/10.3390/molecules17055520
  8. Mimaki, Y., Watanabe, K., Matsuo, Y., and Sakagami, H., Triterpene glycosides from the tubers of Anemone coronaria. Chem. Pharm. Bull. 57, 724-729 (2009). https://doi.org/10.1248/cpb.57.724
  9. Saito, S., Ebashi, J., Sumita, S., Furumoto, T., Nagamura, Y., Nishida, K., and Isiguro, I., Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem.(Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury. Chem. Pharm. Bull. 41, 1395-1401 (1993). https://doi.org/10.1248/cpb.41.1395
  10. Xu, T.-H., Xu, Y.-J., Han, D., Zhao, H.-F., Xie, S.-X., and Xu, D.-M., Triterpenoid saponins from Pulsatilla cernua (Thunb.) Bercht. et Opiz. J. Integr. Plant Biol. 49, 202-206 (2006).
  11. Xu, T.-H., Xu, Y.-J., Li, H.-X., Han, D., Zhao, H.-F., Xie, S.-X., Li, Y., Niu, J.-Z., Si, Y.-S., and Xu, D.-M., Two new triterpenoid saponins from Pulsatilla cernua (Thunb.) Bercht. et Opiz. J. Asian Nat. Prod. Res. 9, 705-711 (2007). https://doi.org/10.1080/10286020600882635
  12. Xu, Y.-J., Bai, L., Liu, Y.-H., Liu, Y., Xu, T.-H., Xie, S.-X., Si, Y.-S., Zhou, H.-O., Liu, T.-H., and Xu, D.-M., A new triterpenoid saponin from Pulsatilla cernua. Molecules 15, 1891-1897 (2010). https://doi.org/10.3390/molecules15031891
  13. Yang, H., Cho, Y.-W., Kim, S.-H., Kim, Y.-C., and Sung, S.-H., Triterpenoidal saponins of Pulsatilla koreana roots. Phytochemistry 71, 1892-1899 (2010). https://doi.org/10.1016/j.phytochem.2010.07.013
  14. Zhang, Q.-W., Ye, W.-C., Che, C.-T., and Zhao, S.-X., Triterpene saponins from Pulsatilla cernua. Acta Pharm. Sin. 35, 756-759 (2000a).
  15. Zhang, Q.-W., Ye, W.-C., Yan, X.-Z., Zhu, G., Che, C.-T., and Zhao, S.-X., Cernuosides A and B, two sucrase inhibitors from Pulsatilla cernua. J. Nat. Prod. 63, 276-278 (2000b). https://doi.org/10.1021/np990207+