Acknowledgement
Supported by : National Research Foundation of Korea (NRF)
References
- Arany Z. PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev. 2008. 18: 426-434. https://doi.org/10.1016/j.gde.2008.07.018
- Barger PM, Kelly DP. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med. 2000. 10: 238-245. https://doi.org/10.1016/S1050-1738(00)00077-3
- Barter PJ, Rye KA. Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome? Arterioscler Thromb Vasc Biol. 2008. 28: 39-46. https://doi.org/10.1161/ATVBAHA.107.160226
- Berger JP, Akiyama TE, Meinke PT. PPARs: therapeutic targets for metabolic disease. Trends Pharmacol Sci. 2005. 26: 244-251. https://doi.org/10.1016/j.tips.2005.03.003
- Brandt JM, Djouadi F, Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem. 1998. 273: 23786-23792. https://doi.org/10.1074/jbc.273.37.23786
- Chai JK, Blaha V, Meguid MM, Laviano A, Yang ZJ, Varma M. Use of orchiectomy and testosterone replacement to explore meal number-to-meal size relationship in male rats. Am J Physiol. 1999. 276: R1366-R1373.
- Chaput E, Saladin R, Silvestre M, Edgar AD. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem Biophys Res Commun. 2000. 271: 445-450. https://doi.org/10.1006/bbrc.2000.2647
- Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML. WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. J Biol Chem. 2002. 277: 24484-24489. https://doi.org/10.1074/jbc.M202449200
- Costet P, Legendre C, More J, Edgar A, Galtier P, Pineau T. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem. 1998. 273: 29577-29585. https://doi.org/10.1074/jbc.273.45.29577
- Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999. 20: 649-688.
- Djouadi F, Aubey F, Schlemmer D, Bastin J. Peroxisome proliferator activated receptor delta (PPARdelta) agonist but not PPARalpha corrects carnitine palmitoyl transferase 2 deficiency in human muscle cells. J Clin Endocrinol Metab. 2005. 90: 1791-1797. https://doi.org/10.1210/jc.2004-1936
- Geary N, Asarian L. Estradiol increases glucagon's satiating potency in ovariectomized rats. Am J Physiol Regul Integr Comp Physiol. 2001. 281: R1290-R1294. https://doi.org/10.1152/ajpregu.2001.281.4.R1290
- Green HJ, Fraser IG, Ranney DA. Male and female differences in enzyme activities of energy metabolism in vastus lateralis muscle. J Neurol Sci. 1984. 65: 323-331. https://doi.org/10.1016/0022-510X(84)90095-9
- Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000. 275: 16638-16642. https://doi.org/10.1074/jbc.275.22.16638
- Ferre P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes. 2004. 53: S43-S50. https://doi.org/10.2337/diabetes.53.2007.S43
- Janssen I, Heymsfield SB, Baumgartner RN, Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol. 2000. 89: 465-471. https://doi.org/10.1152/jappl.2000.89.2.465
- Jay MA, Ren J. Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus. Curr Diabetes Rev. 2007. 3: 33-39. https://doi.org/10.2174/157339907779802067
- Jeong S, Choi WC, Yoon M. Effects of fenofibrate on adipogenesis in female C57BK/6J mice. J Exp Biomed Sci. 2005. 11: 1-8.
- Jeong S, Choi HK, Yoon M. Morphological changes in adipose and liver tissues by 17-estradiol in female ovariectomized C57BL/6 mice. J Exp Biomed Sci. 2007. 13: 99-104.
- Jeong S, Kim M, Han M, Lee H, Ahn J, Kim M, Song YH, Shin C, Nam KH, Kim TW, Oh GT, Yoon M. Fenofibrate prevents obesity and hypertriglyceridemia in low-density lipoprotein receptor-null mice. Metabolism. 2004a. 53: 607-613. https://doi.org/10.1016/j.metabol.2003.12.010
- Jeong S, Han M, Lee H, Kim M, Kim J, Nicol CJ, Kim BH, Choi JH, Nam KH, Oh GT, Yoon M. Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice. Metabolism. 2004b. 53: 1284-1289. https://doi.org/10.1016/j.metabol.2004.05.003
- Jeong S, Yoon M. Inhibition of the actions of peroxisome proliferator-activated receptor alpha on obesity by estrogen. Obesity (Silver Spring). 2007. 15: 1430-1440. https://doi.org/10.1038/oby.2007.171
- Komi PV, Karlsson J. Skeletal muscle fibre types, enzyme activities and physical performance in young males and females. Acta Physiol Scand. 1978. 103: 210-218. https://doi.org/10.1111/j.1748-1716.1978.tb06208.x
- Laurent D, Gounarides JS, Gao J, Boettcher BR. Effects of cevoglitazar, a dual PPARalpha/gamma agonist, on ectopic fat deposition in fatty Zucker rats. Diabetes Obes Metab. 2009. 11: 632-636. https://doi.org/10.1111/j.1463-1326.2008.01017.x
- Mancini FP, Lanni A, Sabatino L, Moreno M, Giannino A, Contaldo F, Colantuoni V, Goglia F. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Lett. 2001. 491: 154-158. https://doi.org/10.1016/S0014-5793(01)02146-9
- Mandard S, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci. 2004. 61: 393-416. https://doi.org/10.1007/s00018-003-3216-3
- Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL. Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes. 2002. 51: 901-909. https://doi.org/10.2337/diabetes.51.4.901
- Mystkowski P, Schwartz MW. Gonadal steroids and energy homeostasis in the leptin era. Nutrition. 2000. 16: 937-946. https://doi.org/10.1016/S0899-9007(00)00458-5
- Serrano A, Del Arco I, Javier Pavon F, Macias M, Perez-Valero V, Rodriguez de Fonseca F. The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats. Neuropharmacology. 2008. 54: 226-234. https://doi.org/10.1016/j.neuropharm.2007.03.007
- Simoneau JA, Lortie G, Boulay MR, Thibault MC, Theriault G, Bouchard C. Skeletal muscle histochemical and biochemical characteristics in sedentary male and female subjects. Can J Physiol Pharmacol. 1985. 63: 30-35. https://doi.org/10.1139/y85-005
- Staels B. PPAR agonists and the metabolic syndrome. Therapie. 2007. 62: 319-326. https://doi.org/10.2515/therapie:2007051
- Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation. 1998. 98: 2088-2093. https://doi.org/10.1161/01.CIR.98.19.2088
- Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol. 2000. 20: 1868-1876. https://doi.org/10.1128/MCB.20.5.1868-1876.2000
- Wade GN. Some effects of ovarian hormones on food intake and body weight in female rats. J Comp Physiol Psychol. 1975. 88: 183-193. https://doi.org/10.1037/h0076186
- Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegen EW. Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation. Diabetes. 2001. 50: 411-417. https://doi.org/10.2337/diabetes.50.2.411
- Yoon M, Jeong S, Nicol CJ, Lee H, Han M, Kim JJ, Seo YJ, Ryu C, Oh GT. Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism. Exp Mol Med. 2002. 34: 481-488. https://doi.org/10.1038/emm.2002.67
- Yoon M, Jeong S, Lee H, Han M, Kang JH, Kim EY, Kim M, Oh GT. Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice. Biochem Biophys Res Commun. 2003. 302: 29-34. https://doi.org/10.1016/S0006-291X(03)00088-3
-
Yoon M. The role of PPAR
${\alpha}$ in lipid metabolism and obesity: Focusing on the effects of estrogen on PPAR${\alpha}$ actions. Pharmacological Research. 2009. 60: 151-159. https://doi.org/10.1016/j.phrs.2009.02.004 -
Yoon M. PPAR
${\alpha}$ in Obesity: Sex Difference and Estrogen Involvement. PPAR Res. 2010. 2010. - Zhang F, Lavan B, Gregoire FM. Peroxisome proliferator-activated receptors as attractive antiobesity targets. Drug News Perspect. 2004. 17: 661-669. https://doi.org/10.1358/dnp.2004.17.10.873918