Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Effect of Extracts from Oriental Plum (Formosa, Oishiwase, Soldam) on LPS-stimulated Raw 264.7 Cells

자두(후무사, 대석, 피자두) 추출물이 LPS로 염증을 유발한 Raw 264.7 세포와 암 세포에 미치는 영향

  • 김세나 (농촌진흥청 국립농업과학원 농식품자원부 기능성식품과) ;
  • 김소영 (농촌진흥청 국립농업과학원 농식품자원부 기능성식품과) ;
  • 김정봉 (농촌진흥청 국립농업과학원 농식품자원부 기능성식품과) ;
  • 박홍주 (농촌진흥청 국립농업과학원 농식품자원부 기능성식품과) ;
  • 조영숙 (농촌진흥청 국립농업과학원 농식품자원부 기능성식품과)
  • Received : 2013.01.21
  • Accepted : 2013.04.15
  • Published : 2013.04.30
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Abstract

The objective of this study is to evaluate the anti-cancer and anti-inflammatory activities of plum (Formosa, Oishiwase, Soldam) for the future development of functional food products. To determine the anti-inflammatory effect of different types of plums, the inhibitory effect of plum extracts on nitric oxide (NO) production were measured in lipopolysaccharide (LPS)-stimulated Raw 264.7 mouse macrophage cells and human cancer cell lines (A549, Ags, Hela, Hep3B). Among the three different plum cultivars, Oishiwase at a concentration of 1 mg/mL showed the highest inhibitory effects on NO production (%) in Raw 264.7 macrophage cells. Moreover, Oishiwase exhibited a higher anti-cancer activity against A549 (renal carcinoma, 50%), Ags (gastric carcinoma, 35%), HeLa (cervical carcinoma, 50%), and Hep3B (hepatocellular carcinoma, 31%) at a concentration on 1 mg/mL, respectively, compared to Formosa and Soldam. Our findings suggest Oishiwase plum extracts may serve as potential dietary sources of natural health promoting substances.

Keywords

References

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