Assessment of Worker's Diisocyanates Skin Exposure at Polyurethane Foam Manufacturing Companies

우레탄 폼 제조 사업장 작업자의 디이소시아네이트 피부노출 평가

  • Published : 2013.06.30

Abstract

Objectives: Skin exposure to diisocyanates may be an important risk factor for respiratory sensitization to leading asthma. However little is known about the extent of worker's diisocyanates skin exposure and the effectiveness of personal protective equipments in polyurethane foam manufacturing companies. This study provides data on diisocyanates skin exposure, surface diisiocyantes contamination of foams and the effectiveness of personal protective gloves in five polyurethane foam manufacturing companies. Materials and methods Colorimetric SWYPE pads are used for the determination of diisocyanates on surfaces of workers skin and polyurethanes foams. Results: The forearms, necks and faces of workers in polyurethane foam manufacturing companies were found to be contaminated with diisocyanates. Heavy contamination with uncured diisocyanates at large block foams surfaces were found. Personal gloves of workers for skin protection showed significant penetrations by diisocyanates. Conclusions: We found that all workers in polyurethane foam manufacturing companies could be exposed to diisocyanates by skin exposure. Also further researches which would better quantify skin exposure are needed.

Keywords

References

  1. Bello D, Woskie SR, Streicher RP, Liu Y, Stowe MH, Eisen EA, Ellenbeckner MJ, Sparer J, Youngs F, Cullen MR, Redlich CA. Polyisocyanates in occupational environments: a critical review of exposure limits and metrics. Am J Ind Med 2004;46:480-491 https://doi.org/10.1002/ajim.20076
  2. Bello D, Spacer CA, Redlich K, Lbrahim MH, Stowe, Y Liu. Slow curing of aliphatic polyisocyanate paints in automotive refinishing: A potential source for skin exposure. J Occup environ Hyg 2007a;4:406-411 https://doi.org/10.1080/15459620701341199
  3. Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin exposure to isocyanates: reason for concern. Eviron Health Perspect 2007b;115(3):328-335
  4. Bernstein DI, Chang-Yeung M.. Asthma in the workplace. 3rd ed. New York: Taylor & Francis Group; 2006.
  5. Boutin M, Dufresne A, Ostiguy C, Lesage J. Determination of airborne isocyanate generated during the thermal degradation of car paint in body repair shops. Ann. Occup Hyg 2006;50(4):385-393 https://doi.org/10.1093/annhyg/mei075
  6. Dietemann-Molard A, Kopferschmitt-Kubler MC, Meyer PD, Tomb R, Pauli G. Allergic asthma due to domestic use of insulating polyurethane foam. Lancet 1991;338-353
  7. Donnelly R, Buik JB, MAcmahon J. Occupational asthma after exposure to plaster casts containing methylene diphenyl diisocyanate. Occup Med(lond) 2004;54(6):432-434 https://doi.org/10.1093/occmed/kqg133
  8. Farfel MR, Lees PS, Rohde CA, Lim BS, Bannon D. Comparison of wipe and cyclone methods for the determination of lead in residential dusts. App Occup Environ Hyg 1994;9(12):1006-1012 https://doi.org/10.1080/1047322X.1994.10388447
  9. Fent K, Jayaraj K, Gold A, Ball L, Nylander-French L. Tape-strip sampling for measuring dermal exposure to 1,6-hexamethylene diisocyanate. Scan J Work Environ Helath 2006;32(3):225-231 https://doi.org/10.5271/sjweh.1003
  10. Gagne S, Lesage J, Ostiguy C, Tra HV. Determination of unreacted 2,4-toluene diisicyanate(2,4TDI) and 2,6-toluene diisocyanate(2,6TDI) in foams at ultratrace level by using HPLC-CIS-MS-MS. Analyst 2003;128:1447-1451 https://doi.org/10.1039/b310463j
  11. Gold RE, Leavitt JRC, Holeslaw T, Tupy D. Exposure of urban applicators to carbaryl. Arch Environ Contam Toxicol 1982;11:63-67 https://doi.org/10.1007/BF01055187
  12. Karal MH, Hauth BA, Riley EJ, Magreni CM. Dermal contact with toluene diisocyanate(TDI) produces respiratory tract sensitivity in guinea pigs. Toxico Appl Pharmacol 1981;58:221-230 https://doi.org/10.1016/0041-008X(81)90426-9
  13. Leavitt JRC, Gold RE, Holeshaw T, Tupy D. Exposure of professional pesticide applicators to carbaryl. Arch Environ Contam Toxicol 1982;11:57-62 https://doi.org/10.1007/BF01055186
  14. Legris M, Lesage J, Trucot A, Bellemare D, Prudhomme H. Exposure to isocyanate during the making of Orthopedic plaster casts(in french). Quebec: CLSC Chutes- de-la-chaudiere-desjardins; 1995.
  15. Littorin M, Welinder H, Skarping G, Dalene M, Skerfving S. Exposure and nasal inflammation in workers heating polyurethane. Int Arch Occup Environ Health 2002;75(7):468-474 https://doi.org/10.1007/s00420-002-0337-1
  16. Methner MM, Fenske RA. Dermal measurement and wipe sampling methods: a review. Appl Occup Environ Hyg 1992;7(9):599-606 https://doi.org/10.1080/1047322X.1992.10388051
  17. Occupational Safety and health administration(OSHA). Sampling for surface contamination I: OSHA technical manual. Salt lake city, Utah; OSHA; 1999.
  18. Rattray NJ, Botham PA, Hext PM, Woodcock DR, Fielding I, Dearman RJ, Kimber I. Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guineapigs. Influence of route of exposure. Toxicol 1994;88:15-30 https://doi.org/10.1016/0300-483X(94)90108-2
  19. Sommer BG, Sherson DL, Kjoller H, Hansen I, Clausen G, Jepsen JR. Asthma caused by methylene diphenyl diisocyanate cast in a nurse(in Danish). Ugeskr Laeger 2000;162(4):505-506
  20. Tartre A. Investigation of surface contamonation in cadmium pigment factory. Appl Occup Environ Hyg 1992;7(5):318-322 https://doi.org/10.1080/1047322X.1992.10390162
  21. Zeller E, Suleswski R. Glove permeation by propylene glycol monomethyl ether acetate- a photoresist solvent used in semiconductor device processing. Appl Occup Environ Hyg 1992;7(6):392-397 https://doi.org/10.1080/1047322X.1992.10390177