생체재료학회지 (Biomaterials Research)

  • 제17권3호
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  • Pages.109-113
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  • 2013
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  • 1226-4601(pISSN)
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  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지

파클리탁셀의 하이드로트로픽 가용화를 위한 양친매성 Poly(4-vinyl benzoic acid-co-diethylacrylamide)의 합성 및 평가

Synthesis and Characterization of Amphiphilic Poly(4-vinyl benzoic acid-co-diethylacrylamide) for Hydrotropic Solubilization of Paclitaxel

  • 오동환 (아주대학교 분자과학기술학과) ;
  • 최종훈 (아주대학교 분자과학기술학과) ;
  • 배진우 (아주대학교 분자과학기술학과) ;
  • 박기동 (아주대학교 분자과학기술학과)
  • Oh, Dong Hwan (Department of Molecular Science and Technology, Ajou University) ;
  • Choi, Jong Hoon (Department of Molecular Science and Technology, Ajou University) ;
  • Bae, Jin Woo (Department of Molecular Science and Technology, Ajou University) ;
  • Park, Ki Dong (Department of Molecular Science and Technology, Ajou University)
  • 발행 : 2013.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

This study describes the synthesis and characterization of micelle-forming amphiphilic copolymers comprised of vinylbenzoic acid (VBA) and diethylacrylamide (DEAAm) for hydrotropic solubilization of paclitaxel. For the synthesis of the copolymer, N-hydroxysuccinimide activated VBA (NSVB) and DEAAm were randomly copolymerized via reversible addition-fragmentation chain transfer (RAFT) polymerization to obtain poly(NSVB-co-DEAAm)(PND), followed by grafting of amine-terminated poly(ethylene glycol) methyl ether (mPEG) to NSVB. The resulting poly(VB-co-DEAAm)-gmPEG( PVDP) and PND were characterized by $^1H$-NMR and TGA. It was found that PVDP could significantly improve water solubility of PTX with increasing concentration of PVDP. At a low concentration, the aqueous solution of PVDP containing PTX looked opaque but became transparent with increasing PVDP concentration. The water solubility of PTX was increased up to 10000-fold at 8 wt% of PVDP, as compared with PTX alone. We measured the average diameter of PVDP at this concentration using a dynamic light scattering. The result showed that PVDP had $137{\pm}18nm$ in diameter, indicating that the improved water solubility of PTX was probably due to the micelle-forming amphiphilic nature of hydrotropic PVDP. Therefore, we expect that the amphiphilic PVDP copolymer with a hydrotropic property can be used to improve water solubility of poorly water-soluble drugs including PTX.

키워드

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