Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

The Effect of BSM-Alginate Sponge on the Enhanced Early Proliferation of Epithelial Cells

BSM-alginate지지체가 Epithelial cells의 초기증식 개선에 미치는 영향

  • Choi, Jeong Yeon (Department of Biomedical Science, Graduate School, Kyungpook National University) ;
  • Oh, Ji Won (Biomedical Research Institute, Joint Institute for Regenerative Medicine, Kyungpook National University Hospital) ;
  • Kim, Su Jeong (Biomedical Research Institute, Joint Institute for Regenerative Medicine, Kyungpook National University Hospital) ;
  • Lim, Jeong Ok (Department of Biomedical Science, Graduate School, Kyungpook National University)
  • 최정연 (경북대학교 일반대학원 의과학과) ;
  • 오지원 (경북대학교병원 생명의학연구소) ;
  • 김수정 (경북대학교병원 생명의학연구소) ;
  • 임정옥 (경북대학교 일반대학원 의과학과)
  • Published : 2013.03.01
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Abstract

Epithelial cells are known to be unstable at different passages, which is one of the big obstacles in hair regeneration. In this study, the effect of a newly developed scaffold composed of alginate and BSM (bladder submucosa matrix) on the adhesion and proliferation of hair epithelial cells was investigated. BSM is an extracellular matrix and known to have various types of growth factors, adhesion molecules, fibrin, albumin, lamina-A/C, keratin 1 and keratin 2A which enhance cell adhesion and proliferation. The BSM-alginate composite was fabricated into a sponge type scaffold by a freeze drying method. Porosity, structural morphology water absorption capacity, cell adhesion property and cytotoxicity of the scaffold were characterized. The results demonstrated that BSM-alginate sponge provided proper physical environment for proliferation of epithelial cells at early stage, indicating the potential of this composite scaffold as a biomaterial for hair regeneration.

Keywords

References

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