Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Serial MR Analysis of Early Permanent and Transient Ischemia in Rats: Diffusion Tensor Imaging and High b Value Diffusion Weighted Imaging

  • Kim, Ji-Hoon (Department of Radiology, Seoul National University Hospital) ;
  • Na, Dong Gyu (Department of Radiology, Seoul National University Hospital) ;
  • Chang, Kee-Hyun (Department of Radiology, Seoul National University Hospital) ;
  • Song, In Chan (Department of Radiology, Seoul National University Hospital) ;
  • Choi, Seung Hong (Department of Radiology, Seoul National University Hospital) ;
  • Son, Kyu Ri (Department of Radiology, Seoul National University Hospital) ;
  • Kim, Kyung Won (Department of Radiology, Seoul National University Hospital) ;
  • Sohn, Chul Ho (Department of Radiology, Seoul National University Hospital)
  • Published : 2013.04.01
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Abstract

Objective: To evaluate the temporal evolution and diagnostic values of the diffusion tensor imaging (DTI) and the high b value diffusion weighted imaging (DWI) in the early permanent and transient cerebral ischemia. Materials and Methods: For permanent or 30-minute transient-ischemia induced 30 rats, DTI and DWIs at both high b (b = 3000 $s/mm^2$) and standard b value (b = 1000 $s/mm^2$) were obtained at the following conditions: at 15, 30, 45, 60 minutes after the occlusion of what for hyperacute permanent ischemia; at 1, 3, 5, 7, 9 hours after the occlusion for acute permanent ischemia; and at 15 minutes before reperfusion, 0.5, 2.5, and 24 hours after reperfusion for transient ischemia. The diffusion parameters and their ratios were obtained and compared between different b values, and among different time points and groups, respectively. Results: For both b values, the apparent diffusion coefficient (ADC) ratio decreased for first three hours, and then slightly increased until 9 hours after the occlusion during a gradual continuous increase of DWI signal intensity (SI) ratio, with excellent correlation between ADC ratios and DWI SI ratios. The DWI showed a higher contrast ratio, but the ADC map showed a lower contrast ratio for permanent ischemia at high b value than at standard b value. Fractional anisotropy (FA) increased for 1 hour, then gradually decreased until 9 hours after the occlusion in permanent ischemia and showed transient normalization and secondary decay along with change in ADC in transient ischemia. Conclusion: This study presents characteristic initial elevation and secondary decay of FA, higher contrast ratio of DWI, and lower contrast ratio of ADC map at high b value, in addition to the time evolutions of diffusion parameters in early permanent and transient ischemia.

Keywords

References

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