The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Malakoplakia in a healthy young female patient

  • Hyun, Kyung Hee (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Shin, Hyun Deok (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Kim, Dong Hoon (Department of Pathology, Dankook University College of Medicine)
  • Published : 2013.07.01
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Abstract

Malakoplakia is a rare granulomatous disease that occurs commonly in the urinary tract and secondarily in the gastrointestinal tract. Most reported cases of malakoplakia are associated with immunosuppressive diseases or chronic prolonged illness. Here, we report a rare case of malakoplakia in a young healthy adolescent without any underlying disease. A 19-year-old female was referred to our hospital following the discovery of multiple rectal polyps with sigmoidoscopy. She had no specific past medical history but complained of recurrent abdominal pain and diarrhea for 3 months. A colonoscopy revealed diverse mucosal lesions including plaques, polyps, nodules, and mass-like lesions. Histological examination revealed a sheet of histiocytes with pathognomonic Michaelis-Gutmann bodies. We treated the patient with ciprofloxacin, the cholinergic agonist bethanechol, and a multivitamin for 6 months. A follow-up colonoscopy revealed that her condition was resolved with this course of treatment.

Keywords

References

  1. Yousef GM, Naghibi B, Hamodat MM. Malakoplakia outside the urinary tract. Arch Pathol Lab Med 2007;131:297-300.
  2. Weinrach DM, Wang KL, Cisler JJ, Diaz LK. Pathologic quiz case: a 54-year-old liver transplant recipient with diffuse thickening of the sigmoid colon: malakoplakia of the colon associated with liver transplant. Arch Pathol Lab Med 2004;128:e133-e134.
  3. Renshaw A, Murphy W. Lower urinary tract. In: Cortran RS, Kumar V, Collins T, Robbins SL, eds. Robbins Pathologic Basis of Disease. 6th ed. Philadelphia: Saunders, 1999:1002.
  4. Lewin KJ, Fair WR, Steigbigel RT, Winberg CD, Droller MJ. Clinical and laboratory studies into the pathogenesis of malacoplakia. J Clin Pathol 1976;29:354-363. https://doi.org/10.1136/jcp.29.4.354
  5. Abdou NI, NaPombejara C, Sagawa A, et al. Malakoplakia: evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. N Engl J Med 1977;297:1413-1419. https://doi.org/10.1056/NEJM197712292972601
  6. Biggar WD, Crawford L, Cardella C, Bear RA, Gladman D, Reynolds WJ. Malakoplakia and immunosuppressive therapy: reversal of clinical and leukocyte abnormalities after withdrawal of prednisone and azathioprine. Am J Pathol 1985;119:5-11.
  7. Bates AW, Dev S, Baithun SI. Malakoplakia and colorectal adenocarcinoma. Postgrad Med J 1997;73:171-173. https://doi.org/10.1136/pgmj.73.857.171
  8. Ahn BG, Sun BH, Kim HS. A case report of malakoplakia occurred in the ascending colon. J Korean Soc Coloproctol 1996;12:149-153.
  9. Koh KC, Rhee PL, Kim JJ, et al. Malakoplakia. Korean J Gastrointest Endosc 1996;16:254-259.
  10. Lee DH, Cheong JY, Park WI, et al. A case of malakoplakia treated by antibiotics in the rectum. Korean J Gastrointest Endosc 2005;30:99-102.

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