Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Bio-active Substances and Physiological Activity of Pears

배(Pear)의 생리활성 물질 및 생리활성 효능

  • Min, Tae Sun (National Research Foundation of Korea) ;
  • Park, Min Jung (Korean Pear Export Research Organization, College of Veterinary Medicine, Chonnam National University) ;
  • Moon, Jae Hak (Korean Pear Export Research Organization, College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Wol Soo (Korean Pear Export Research Organization, College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Sang Hyun (Korean Pear Export Research Organization, College of Veterinary Medicine, Chonnam National University) ;
  • Cho, Young Don (National Research Foundation of Korea) ;
  • Park, Soo Hyun (Korean Pear Export Research Organization, College of Veterinary Medicine, Chonnam National University)
  • Received : 2012.11.05
  • Accepted : 2012.12.24
  • Published : 2013.06.30
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Abstract

Pear (Pyrus spp.) fruit has been widely consumed fruits in the world. Pears are generally classified as Asian pears (Japanese pear: Pyruspyritolia N, China pear: P. ussuriensis M) and European pears (Pyrus communis L.). Pears have been reported to contain the diverse bioactive substances and the study on screening for bioactive compounds and its functional role in pear has been still going on. Therefore, this review article provides an overview of bioactive compounds and physiological effects of pears on diverse diseases.

배는 전세계적으로 많이 소모되고 있는 과일이다. 일반적으로 배는 아시아 배와 유럽 배로 분류된다. 배는 다양한 생리활성 물질을 보유하는 것으로 알려져 있으며 이에 대한 기능성 연구가 계속 되어져 진행되고 있다. 따라서 본 종설에서는 지금까지 알려진 배의 생리활성 물질들의 개요 및 다양한 질병들에 대한 예방효과에 대해서 알아보고자 하였다.

Keywords

References

  1. Akiu S, Suzuki Y, Fujinuma Y, Asahara T, and Fukada M (1988) Inhibitory effect of arbutin on melanogenesis: biochemical study in cultured B16 melanoma cells and effect on the UV-induced pigmentation in human skin. Proc Jpn Soc InVest Dermatol 12, 138-9.
  2. An BJ, Lee JT, Kwak JH, Park JM, Lee JY, Son JH et al. (2004) Biological Activity of Polyphenol Group Fraction from Korean Pear Peel. J Korean Soc Appl Biol Chem 47, 92-5.
  3. Bandyopadhyay G, Biswas T, Roy KC, Mandal S, Mandal C, Pal BC et al. (2004) Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Blood 104, 2514-22. https://doi.org/10.1182/blood-2003-11-4065
  4. Bond V, Ordor O, Bruckner G, Webb P, Kotchen T, Tearney RJ et al. (1989) Effects of dietary fish oil or pectin on blood pressure and lipid metabolism in the DOCA-salt hypertensive rat. J Nutr 119, 813-7. https://doi.org/10.1093/jn/119.5.813
  5. Branca MS and Paula BA (2000) Phenolic profile in the evaluation of commercial quince jellies authenticity. Food Chem 71, 281-5. https://doi.org/10.1016/S0308-8146(00)00134-5
  6. Chlopc Kov SPJ, Miketov P, Sousek J, Lichnovsk V, and Sim Nek V (2004) Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part II. caffeic, chlorogenic and rosmarinic acids. Phytother Res, 18, 408-13. https://doi.org/10.1002/ptr.1461
  7. Choi HJ, Park JH, Han HS, Son JH, Son GM, Bae JH et al. (2004) Effect of polyphenol compound from Korean pear (pyrus pyrifolia Nakai) on lipid metabolism. J Korean Soc Food Sci Nutr 33, 299-304. https://doi.org/10.3746/jkfn.2004.33.2.299
  8. Choi JH, Lee EY, Kim JS, Choi GB, Jung SG, Ham YS et al. (2006) Physiological activities according to cultivars and parts of Ulsan pear. J Korean Soc Appl Biol Chem 49, 43-8.
  9. Cui T, Nakamura K, Ma L, Li JZ, and KAYAHARA H (2005) Analyses of arbutin and chlorogenic acid, the major phenolic constituents in oriental pear. J Agri Food Chemistry 53, 3882-7. https://doi.org/10.1021/jf047878k
  10. Fisher RB and Bennett AB (1991) Role of cell wall hydrolase in fruit ripening. Ann Rev Plant Mol Bio 42, 675-703. https://doi.org/10.1146/annurev.pp.42.060191.003331
  11. Hamauzu Y, Forest F, Hiramatsu K, and Sugimoto M (2007) Effect of pear (Pyrus communis L.) procyanidins on gastric lesions induced by HCl/ ethanol in rats. Food Chemistry 100, 255-63. https://doi.org/10.1016/j.foodchem.2005.09.050
  12. Hamauzu Y, Yasui H, Inno T, Kume C, and Omanyuda M (2005) Phenolic profile, antioxidant property, and anti-influenza viral activity of Chinese quince, quince and apple fruits. J Agri Food Chem 53, 928-34. https://doi.org/10.1021/jf0494635
  13. Heo BK, Park YS, Park YJ, Jung KJ, Cho JY, Oh KT et al. (2009) Chemical composition and physiological activity of native pear c.v. 'Baekwoon'. Korean J. Community Living Science 20, 549-58.
  14. Hildebracd DC and Schroth MN (1963) Relation of arbutin-hydroquinone in pear blossoms to invasion by E. amyloVora. Nature, 197, 513. https://doi.org/10.1038/197513a0
  15. Hwang YK and Pyo MY (2005) Effects of pear (Pyrus pyrifolia) Methanol extracts on the proliferation and the cytokines poduction of mouse splenocytes. Yakhak Hoeji 49, 25-9.
  16. Jin S and Sato N (2003) Benzoquinone, the substance essential for antibacterial activity in aqueous extracts from succulent young shoots of the pear Pyrus spp. Phytochemistry. 62, 101-7. https://doi.org/10.1016/S0031-9422(02)00444-2
  17. Kim JS and Na CS (2002) Effects of pear phenolic compound in the STZtreated mice for induction of diabetes. J Korean Soc Food Sci Nutr 31, 1107-11. https://doi.org/10.3746/jkfn.2002.31.6.1107
  18. Kim JS and Na CS (2004) Effect of Rehmanniae Radix and Pear phenolic compound on the STZ-treated mice for induction of diabetes. J Korean Soc Food Sci Nutr, 33, 66-71. https://doi.org/10.3746/jkfn.2004.33.1.066
  19. Kim OK, Lee TG, Park YB, Park DC, Lee YW, Yeo SG et al. (1996) Inhibition of xanthine oxidase by seaweed extract. J. Kor. Soc. Food Sci Nutr 25, 1069-73.
  20. Krakauer T (2002) The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines. Immunopharmacol Immunotoxicol 24, 113-9. https://doi.org/10.1081/IPH-120003407
  21. Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF et al. (2002) Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 113, 71-88S. https://doi.org/10.1016/S0002-9343(01)00995-0
  22. Lee HS, Isse T, Kawamoto T, Woo HS, Kim AK, Park JY et al. (2012) Effects and Action Mechanisms of Korean Pear (Pyrus pyrifolia cv. Shingo) on Alcohol Detoxification. Phytother Res 26, 1153-8.
  23. Lee JC, Pak SC, Lee SH, Na CS, Lim SC, Song CH et al. (2004) Asian pear pectin administration during presensitization inhibits allergic response to ovalbumin in BALB/c mice. J Altern Complement Med. 10, 527-34. https://doi.org/10.1089/1075553041323867
  24. Lee JT and An BJ (2002) Detection of physical activity of Salicornia herbacea. Kor J Herbology 17, 61-9.
  25. Lee KH, Cho JY, Lee HJ, Ma YK, Kwon J, Park SH et al. (2011) Hydroxycinnamoylmalic acids and their methyl esters from pear (Pyrus pyrifolia Nakai) fruit peel. J Agric Food Chem, 59, 10124-8. https://doi.org/10.1021/jf2022868
  26. Lee SE, Seong NS, Park CG, and Seong JS (2002) Screening for antioxidative of oriental medicinal plant materials. Kor J Medicinal Crop Sci 10, 171-6.
  27. Leontowicx M, Gorinstein S, Leontowicz H, Krzeminski R, Lojek A, Katrich E et al. (2003) Apple and pear peel and pulp and their influence on plasma lipids and antioxidant potentials in rats fed cholesterol-containing diets. J Agri Food Chem 51, 5780-5. https://doi.org/10.1021/jf030137j
  28. Lin LZ and Harnly JM (2008) Phenolic compounds and chromatographic profiles of pear skins (Pyrus spp.). J Agric Food Chem 56, 9094-101. https://doi.org/10.1021/jf8013487
  29. Miyata T, Oda O, Inagi R, Sugiyama S, Miyama A, Maeda K et al. (1990) Molecular and functional identification and purification of complement component factor D from urine of patients with chronic renal failure. Mol Immunol, 27, 637-44. https://doi.org/10.1016/0161-5890(90)90006-L
  30. Morton LW, Abu-Amsha Caccetta R, Puddey IB, and Croft KD (2000) Chemistry and biological effects of dietary phenolic compounds: relevance to cardiovascular disease. Clin Exp Pharmacol Physiol 27, 152-9. https://doi.org/10.1046/j.1440-1681.2000.03214.x
  31. Na CS, Yun DH, Choi DH, Kim JS, Cao C, and Eun JB (2003a) The effect of pear pectin on blood pressure, plasma renin, ANP and cardiac hypertrophy in hypertensive rat induced by 2K1C. J Kor Soc Food Sci Nutr 32, 700-5. https://doi.org/10.3746/jkfn.2003.32.5.700
  32. Na CS, Yun DH, Choi DH, Kim JS, Cao CH, and Eun JB (2003b) Effects of pear phenolic compound on blood pressure, plasma renin, ANP and cardiac hypertrophy in Hypertensive RAT induced by 2K1C. Kor J Ori Physiol Pathol 17, 363-7.
  33. Nakatani N, Kayano S, Kikuzaki H, Sumino K, Katagari K, and Mitani T (2000) Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L.). J Agric Food Chem 48, 5512-6. https://doi.org/10.1021/jf000422s
  34. Oleszek WO, Amiot MJ, and Aubert S (1994) Identification of some phenolics in pear fruit. J Agric Food Chem 42, 1261-5. https://doi.org/10.1021/jf00042a002
  35. Osawa K, Miyazaki K, Imai H, Arakawa T, Yasuda H, and Takeya K (1999) Inhibitory effects of Chinese quince (Chaenomeles sinensis) on hyaluronidase and histamine release from rat mast cells. Natural Medicines 53, 188-93.
  36. Park YS, Kim BW, Kim TC, Jang HG, Chon SU, Cho JY et al. (2008) Physiological activity of methanol extracts form Korean kiwifruits. Kor J Hort Sci Technol 26, 495-500.
  37. Schieber A, Keller P, and Carle R (2001) Determination of phenolic acids and flavonoids of apple and pear by high-performance liquid chromatography. J Chromatogr A 910, 265-73. https://doi.org/10.1016/S0021-9673(00)01217-6
  38. Schindler G, Patzak U, Brinkhaus B, von Niecieck A, Wittig J, Krähmer N et al. (2002) Urinary excretion and metabolism of arbutin after oral administration of Arctostaphylos uvae ursi extract as film-coated tablets and aqueous solution in healthy humans. J Clin Pharmacol 42, 920-7. https://doi.org/10.1177/009127002401102740
  39. Shinomiya K, Omichi J, Ohnishi R, Ito H, Yoshida T, and Kamei C (2004) Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats. Eur J Pharmacol 504, 185-9. https://doi.org/10.1016/j.ejphar.2004.09.054
  40. Son MY and Park SK (2006) Chemical components and nitrite scavenging activity of various solvent extracts from onions. Kor J Food Preserv 13, 762-8.
  41. Tanaka T, Kojima T, Kawamori T, Wang A, Suzui M, Okamoto K et al. (1993) Inhibition of 4-nitroquinoline-1-oxideinduced rat tongue carcinogenesis by the naturally occurring phenolic caffeic, ellagic, chlorogenic and ferulic acids. Carcinogenesis 14, 1321-5. https://doi.org/10.1093/carcin/14.7.1321
  42. Wald B, Wray V, and Galensa R (1989) Malonated flavonol glycosides and 3, 5-dicaffeoylquinic acid from pears. Phytochemistry 28, 663-4. https://doi.org/10.1016/0031-9422(89)80083-4
  43. Ward FW, Coates ME, and Walker R (1986) Nitrate reduction, gastrointestinal pH and N-nitrosation in gnotobiotic and conventional rats. Food Chem Toxicol 24, 17-22. https://doi.org/10.1016/0278-6915(86)90258-9
  44. Walker R (1996) The metabolism of dietary nitrites. Biochem Soc Trans 24, 780-5. https://doi.org/10.1042/bst0240780
  45. Wu HZ, Luo J, Yin YX, and Wei Q (2004) Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos Lonicerae on macrophage. Acta Pharmacol Sin 25, 1685-9.
  46. Yang M, Kim S, Lee E, Cheong HK, Chang SS, Kang D et al. (2003) Sources of polycyclic aromatic hydrocarbon exposure in non-occupationally exposed Koreans. Environ Mol Mutagen 42, 250-7. https://doi.org/10.1002/em.10196
  47. Yeh CT and Yen GC (2003) Effects of phenolic acids on human phenolsulfotransferases in relation to their antioxidant activity. J Agric Food Chem 51, 1474-9. https://doi.org/10.1021/jf0208132
  48. Yu TJ (1989) Sikpumbogam. Munundang, Korea,
  49. Yun BC, Kim KY, and Park SH (2006) Effects of pear extracts cultured under conventional and environment-friendly conditions on cell proliferation in rat hepatocytes. J Korean Soc Appl Biol Chem 49, 233-7.
  50. Zang LY, Cosma G, Gardner H, Castranova V, and Vallyathan V (2003) Effect of chlorogenic acid on hydroxyl radical. Mol Cell Biochem 247, 205-10. https://doi.org/10.1023/A:1024103428348
  51. Zhang X, Lee FZ, and Eun JB (2008) Physicochemical properties an glucose transport retarding effect of pectin from flesh of Asian pear at different growth stages. Kor J Food Sci Technol, 40, 491-6.
  52. Zhang YB, Choi HJ, Han HS, Park JH, Son JH, Bae JH et al. (2003) Chemical structure of polyphenol isolated from Korean pear (pyrus pyrifolia Nakai). Korean J Food Sci Technol 35, 959-67.
  53. Zheng Q, Hirose Y, Yoshimi N, Murakami A, Koshimizu K, Ohigashi H et al. (2002) Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. J. Cancer Res. Clin. Oncol 128, 539-46. https://doi.org/10.1007/s00432-002-0373-y
  54. Zhu QY, Holt RR, Lazarus SA, Orozco TJ, and Keen CL (2002) Inhibitory effects of cocoa flavanols and procyanidin oligomers on free radicalinduced erythrocyte hemolysis. Experimental Biology and Medicine, 227, 321-9. https://doi.org/10.1177/153537020222700504

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