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Evaluation of the Antioxidant Activity and Anti-Inflammatory Effect of Hericium erinaceus Water Extracts

노루궁뎅이 버섯 열수추출물의 항산화 활성과 항염증 효능 평가

  • Kim, Da Hye (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Park, Sa Ra (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Debnath, Trishina (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Hasnat, Md. Abul (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Pervin, Mehnaz (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Lim, Beong Ou (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University)
  • 김다혜 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 박사라 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 트리쉬나 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 하스낫 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 펄빈 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 임병우 (건국대학교 의료생명대학 응용생화학 전공)
  • Received : 2013.01.18
  • Accepted : 2013.03.18
  • Published : 2013.04.30

Abstract

This study was conducted to determine the antioxidative activity of Hericium erinaceus (HE) and we investigated that HE extract contributes to cell proliferation and to anti-LPS-induced inflammation. HE extract showed high DPPH free radical scavenging activity. However, the reducing power activity slightly increased in compare with control. Nitrite scavenging activity, ABTS radical scavenging activity, SOD-like activity of HE were elevated in dose-dependent. The level of total phenolic and flavonoid showed 30.06 mg/100 g and 33.86 mg/100 g, respectively. Linoleic acid oxidation inhibition had reached a maximum level on the fourth day and started to drop from the fifth day. HE extract contributes to cell proliferation on the RAW 264.7 cell. Our finding demonstrated that water extracts of HE possess significant antioxidant activities and may be suggested a new potential source of anti-inflammatory medicines.

Keywords

Acknowledgement

Supported by : 한국학술진흥재단

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