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Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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Ikwi-tang for the treatment of allergic rhinitis as a traditional medicine

  • Go, Ji-Hyun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Jung, Jae-Hun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Chang, Yu-Jung (Center for University-Wide Research Facilities, Chonbuk National University) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Chung, Yun-Jo (Center for University-Wide Research Facilities, Chonbuk National University)
  • Received : 2012.11.27
  • Accepted : 2013.02.15
  • Published : 2013.02.28
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Abstract

Ikwi-tang (IW) is an oriental medicine that has been used for the treatment of general symptoms due to a stomach yin deficiency. The aim of this study is to investigate precisely the effect of IW on allergic rhinitis (AR). We well show the effects and the mechanism of IW in the ovalbumin-sensitized AR model. IW significantly decreased the number of nasal/ear rubs and the increment of IgE levels in the AR mice. The levels of interferon-${\gamma}$ were enhanced while the levels of interleukin (IL)-4 were reduced in the spleen tissue of the IW-administered AR mice. Expressions of IL-$1{\beta}$ and cyclooxygenase-2 were inhibited by IW-administration in the nasal mucosa tissues. Infiltration of eosinophils and mast cells was decreased in the IW-administered AR mice. Our results indicate that IW may attenuate the development of AR by the inhibition of caspase-1 activity.

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References

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