References
- Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-1693. https://doi.org/10.1016/S0006-2952(99)00212-9
- Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 1999;55:567-575. https://doi.org/10.1007/s002280050674
- Sung HS. Present and future on the processing of ginseng. Korean J Ginseng Sci 1986;10:218-232.
- Kitagawa I, Taniyama T, Shibuya H, Noda T, Yoshikawa M. Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root. Yakugaku Zasshi 1987;107:495-505. https://doi.org/10.1248/yakushi1947.107.7_495
- Kim JH. Cardiovascular diseases and Panax ginseng: a review on molecular mechanisms and medical applications. J Ginseng Res 2012;36:16-26. https://doi.org/10.5142/jgr.2012.36.1.16
- Song JY, Akhalaia M, Platonov A, Kim HD, Jung IS, Han YS, Yun YS. Effects of polysaccharide ginsan from Panax ginseng on liver function. Arch Pharm Res 2004;27:531-538. https://doi.org/10.1007/BF02980127
- Kaneko H, Nakanishi K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically, its anti-stress action for prevention of disease. J Pharmacol Sci 2004;95:158-162. https://doi.org/10.1254/jphs.FMJ04001X5
- Walsh K, Alexander G. Alcoholic liver disease. Postgrad Med J 2000;76:280-286. https://doi.org/10.1136/pmj.76.895.280
- Gramenzi A, Caputo F, Biselli M, Kuria F, Loggi E, Andreone P, Bernardi M. Alcoholic liver disease: pathophysiological aspects and risk factors. Aliment Pharmacol Ther 2006;24:1151-1161. https://doi.org/10.1111/j.1365-2036.2006.03110.x
- Lieber CS. Biochemical and molecular basis of alcohol-induced injury to liver and other tissues. N Engl J Med 1988;319:1639-1650. https://doi.org/10.1056/NEJM198812223192505
- Purohit V, Gao B, Song BJ. Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 2009;33:191-205. https://doi.org/10.1111/j.1530-0277.2008.00827.x
- Das SK, Nayak P, Vasudevan DM. Biochemical markers for alcohol consumption. Indian J Clin Biochem 2003;18:111-118.
- Kook S, Han HK, Kim GH, Choi K. The anti-hepatotoxic effect of ginseng in rats: meta-analysis. J Ginseng Res 2008;32:161-170. https://doi.org/10.5142/JGR.2008.32.2.161
- Lee YJ, Pantuck CB, Pantuck EJ. Effect of ginseng on plasma levels of ethanol in the rat. Planta Med 1993;59:17-19. https://doi.org/10.1055/s-2006-959595
- Park HM, Kim SJ, Go HK, Kim GB, Kim SZ, Kim JS, Kang HS. Korean red ginseng prevents ethanol-induced hepatotoxicity in isolated perfused rat liver. Korean J Vet Res 2011;51:159-164.
- Sturgill MG, Lambert GH. Xenobiotic-induced hepa-totoxicity: mechanisms of liver injury and methods of monitoring hepatic function. Clin Chem 1997;43(8 Pt 2):1512-1526.
- Lynch WJ, Roth ME, Carroll ME. Biological basis of sex differences in drug abuse: preclinical and clinical studies. Psychopharmacology (Berl) 2002;164:121-137. https://doi.org/10.1007/s00213-002-1183-2
- Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993;123:1939-1951. https://doi.org/10.1093/jn/123.11.1939
- Wooles WR. Prevention of the acute ethanol-induced fatty liver by antihistamines and stimulants of hepatic microsomal enzyme activity. Toxicol Appl Pharmacol 1968;12:186-193. https://doi.org/10.1016/0041-008X(68)90030-6
- Lieber CS, DeCarli LM. Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol 1989;24:197-211.
- Kwak YS, Kyung JS, Kim JS, Cho JY, Rhee MH. Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull 2010;33:468-472. https://doi.org/10.1248/bpb.33.468
- Yagi K. Lipid peroxides and human diseases. Chem Phys Lipids 1987;45:337-351. https://doi.org/10.1016/0009-3084(87)90071-5
- Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
- Carr TP, Andresen CJ, Rudel LL. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem 1993;26:39-42. https://doi.org/10.1016/0009-9120(93)90015-X
- Freund RJ, Wilson WJ. Statistical methods. San Diego: Academic Press, 1997.
- Baldi E, Burra P, Plebani M, Salvagnini M. Serum malondialdehyde and mitochondrial aspartate aminotransferase activity as markers of chronic alcohol intake and alcoholic liver disease. Ital J Gastroenterol 1993;25:429-432.
- Goldberg DM, Watts C. Serum enzyme changes as evidence of liver reaction to oral alcohol. Gastroenterology 1965;49:256-261.
- Lee DH, Blomhoff R, Jacobs DR Jr. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 2004;38:535-539. https://doi.org/10.1080/10715760410001694026
- Cederbaum AI, Lu Y, Wu D. Role of oxidative stress in alcohol-induced liver injury. Arch Toxicol 2009;83:519-548. https://doi.org/10.1007/s00204-009-0432-0
- Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001;38:263-355. https://doi.org/10.1080/20014091084227
- Teschke R, Neuefeind M, Nishimura M, Strohmeyer G. Hepatic gamma-glutamyltransferase activity in alcoholic fatty liver: comparison with other liver enzymes in man and rats. Gut 1983;24:625-630. https://doi.org/10.1136/gut.24.7.625
- Shaw S, Rubin KP, Lieber CS. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Evidence of lipid peroxidation. Dig Dis Sci 1983;28:585-589. https://doi.org/10.1007/BF01299917
- Yuan HD, Kim JT, Kim SH, Chung SH. Ginseng and diabetes: the evidences from in vitro, animal and human studies. J Ginseng Res 2012;36:27-39. https://doi.org/10.5142/jgr.2012.36.1.27
- Kim YK, Guo Q, Packer L. Free radical scavenging activity of red ginseng aqueous extracts. Toxicology 2002;172:149-156. https://doi.org/10.1016/S0300-483X(01)00585-6
- Videla LA, Valenzuela A. Alcohol ingestion, liver glutathione and lipoperoxidation: metabolic interrelations and pathological implications. Life Sci 1982;31:2395-2407. https://doi.org/10.1016/0024-3205(82)90743-3
- Kera Y, Kiriyama T, Komura S. Conjugation of acetaldehyde with cysteinylglycine, the first metabolite in glutathione breakdown by gamma-glutamyltranspeptidase. Agents Actions 1985;17:48-52. https://doi.org/10.1007/BF01966681
- Molina MF, Sanchez-Reus I, Iglesias I, Benedi J. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharm Bull 2003;26:1398-1402. https://doi.org/10.1248/bpb.26.1398
- Devipriya N, Srinivasan M, Sudheer AR, Menon VP. Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study. Singapore Med J 2007;48:311-318.
- Fernandez-Checa JC, Kaplowitz N. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol 2005;204:263-273. https://doi.org/10.1016/j.taap.2004.10.001
- Park HM, Kim SJ, Mun AR, Go HK, Kim GB, Kim SZ, Jang SI, Lee SJ, Kim JS, Kang HS. Korean red ginseng and its primary ginsenosides inhibit ethanol-induced oxidative injury by suppression of the MAPK pathway in TIB-73 cells. J Ethnopharmacol 2012;141:1071-1076. https://doi.org/10.1016/j.jep.2012.03.038
- Kim JW, Lee HB, Joo CN. Uptake of Korean ginseng saponin by rat hepatic mitochondria in vitro. Korean Biochem J 1983;16:142-150.
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