Korean Journal of Radiology

  • 제14권4호
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  • Pages.643-652
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  • 2013
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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Hyperfunction Thyroid Nodules: Their Risk for Becoming or Being Associated with Thyroid Cancers

  • Lee, Eun Sun (Department of Radiology, Seoul National University Hospital) ;
  • Kim, Ji-Hoon (Department of Radiology, Seoul National University Hospital) ;
  • Na, Dong Gyu (Department of Radiology, Seoul National University Hospital) ;
  • Paeng, Jin Chul (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Min, Hye Sook (Department of Pathology, Seoul National University Hospital) ;
  • Choi, Seung Hong (Department of Radiology, Seoul National University Hospital) ;
  • Sohn, Chul Ho (Department of Radiology, Seoul National University Hospital) ;
  • Chang, Ki-Hyun (Department of Radiology, Seoul National University Hospital)
  • 투고 : 2012.09.14
  • 심사 : 2013.03.16
  • 발행 : 2013.07.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To retrospectively evaluate the risk of thyroid cancer in patients with hyperfunctioning thyroid nodules through ultrasonographic-pathologic analysis. Materials and Methods: Institutional review board approval was obtained and informed consent was waived. From 2003 to 2007, 107 patients consecutively presented with hot spots on thyroid scans and low serum thyroid-stimulating hormone levels. Among them, 32 patients who had undergone thyroid ultrasonography were analyzed in this study. Thyroid nodules depicted on ultrasonography were classified based on size and categorized as benign, indeterminate, or suspicious malignant nodules according to ultrasonographic findings. The thyroid nodules were determined as either hyperfunctioning or coexisting nodules and were then correlated with pathologic results. Results: In 32 patients, 42 hyperfunctioning nodules (mean number per patient, 1.31; range, 1-6) were observed on thyroid scans and 68 coexisting nodules (mean, 2.13; range, 0-7) were observed on ultrasonography. Twenty-five patients (78.1%) had at least one hyperfunctioning (n = 17, 53.1%) or coexisting (n = 16, 50.0%) nodule that showed a suspicious malignant feature larger than 5 mm (n = 8, 25.0%), or an indeterminate feature 1 cm or greater (n = 20, 62.5%) in diameter, which could have been indicated by using fine needle aspiration (FNA). Seven patients were proven to have 11 thyroid cancers in 3 hyperfunctioning and 8 coexisting nodules. All of these had at least one thyroid cancer, which could have been indicated by using FNA. The estimated minimal risk of thyroid cancer was 6.5% (7/107). Conclusion: Patients with hyperfunctioning nodules may not be safe from thyroid cancer because hyperfunctioning nodules can coexist with thyroid cancer nodules. To screen out these cancers, ultrasonography should be performed.

키워드

참고문헌

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피인용 문헌

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  2. Follicular Thyroid Cancer with Pulmonary Metastasis Presenting as Toxic Autonomously Functioning Thyroid Nodule vol.1, pp.1, 2013, https://doi.org/10.4158/ep14384.cr
  3. Is there still a role for thyroid scintigraphy in the workup of a thyroid nodule in the era of fine needle aspiration cytology and molecular testing? vol.5, pp.None, 2013, https://doi.org/10.12688/f1000research.7880.1
  4. 2017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology vol.19, pp.4, 2018, https://doi.org/10.3348/kjr.2018.19.4.632
  5. Are cytologic and histopathologic features of hot thyroid nodules different from cold thyroid nodules? vol.47, pp.9, 2013, https://doi.org/10.1002/dc.24251
  6. The value of ultrasonography for the indication of fine‐needle aspiration in autonomous thyroid nodules vol.49, pp.3, 2013, https://doi.org/10.1002/dc.24659
  7. Malignancy risk of hyperfunctioning thyroid nodules compared with non-toxic nodules: systematic review and a meta-analysis vol.14, pp.1, 2021, https://doi.org/10.1186/s13044-021-00094-1