The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Non-Alcoholic Fatty Liver Disease and Colonic Neoplasm

비알콜성 지방간질환과 대장신생물

  • Kim, Jong Wook (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Byeon, Jeong-Sik (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine)
  • 김정욱 (울산대학교 의과대학 서울아산병원 소화기내과) ;
  • 변정식 (울산대학교 의과대학 서울아산병원 소화기내과)
  • Published : 2013.03.01
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Abstract

The incidence of colorectal neoplasm including adenomas and carcinomas is increasing in Korea. It has been reported that certain components of the metabolic syndrome including abdominal obesity and abnormal glucose metabolism are associated with increased risk for colorectal cancer. The mechanism involved is most likely linked to metabolic stress, which is associated with increased levels of insulin-like growth factor-1 and TNF-$\alpha$, which promote cell proliferation and survival. Non-alcoholic fatty liver disease (NAFLD) is commonly referred to as the hepatic manifestation of the metabolic syndrome. The study by Lee et al. showed that NAFLD is associated with increased risk for colonic neoplasm. Further studies are needed to decide whether patients with NAFLD require a screening colonoscopy at a younger age than currently recommended.

Keywords

References

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