DOI QR코드

DOI QR Code

A Case of Infective Endocarditis Caused by Community-Acquired Acinetobacter baumannii

지역사회에서 획득된 Acinetobacter baumannii에 의한 감염성 심내막염 1예

  • Kim, Min Hyung (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Ahn, Jin Young (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Ku, Nam Su (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Han, Sang Hoon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Choi, Jun Yong (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Song, Young Goo (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, June Myung (Department of Internal Medicine, Yonsei University College of Medicine)
  • 김민형 (연세대학교 의과대학 내과학교실) ;
  • 안진영 (연세대학교 의과대학 내과학교실) ;
  • 구남수 (연세대학교 의과대학 내과학교실) ;
  • 한상훈 (연세대학교 의과대학 내과학교실) ;
  • 최준용 (연세대학교 의과대학 내과학교실) ;
  • 송영구 (연세대학교 의과대학 내과학교실) ;
  • 김준명 (연세대학교 의과대학 내과학교실)
  • Received : 2012.03.23
  • Accepted : 2012.08.27
  • Published : 2013.02.01

Abstract

Acinetobacter baumannii has become an important pathogen that causes healthcare-associated infections, including pneumonia, bacteremia, and urinary tract infection. Only sporadic cases of infective endocarditis (IE) have been reported worldwide, and in particular, community-acquired IE caused by A. baumannii is very rare. To our knowledge, no case has ever been reported in Korea. We report a 30-year-old woman who recovered f2012-03-23rom native-valve community-acquired IE caused by A. baumannii. She did not have any underlying diseases and presented with left-sided weakness, dysarthria, and fever. On investigation of acute cerebral infarction, a vegetation on her anterior mitral leaflet was found in echocardiography, and A. baumannii was cultured from the blood. In this case, A. baumannii showed intermediate resistance to cefotaxime and was sensitive to all other antibiotics. She underwent antibiotic therapy with cefoperazone/sulbactam for 5 weeks, without surgery. Consequently, the vegetation was absent in follow-up echocardiography, and no complications related to IE developed.

기저 질환이 없는 젊은 여성이 급성 뇌경색이 발생하여 내원하였으며 A. baumannii 균혈증이 확인되었다. 경흉부 심초음파에서 우식증이 관찰되어 심내막염 진단과 함께 cefoperazon/sulbactam을 총 5주 동안 사용한 결과 추가적인 합병증이 발생하지 않고 심내막염이 완치되었다. 지역사회 획득 A.baumannii에 의하여 발생한 감염성 심내막염의 국내 첫 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Falagas ME, Karveli EA, Kelesidis I, Kelesidis T. Community- acquired Acinetobacter infections. Eur J Clin Microbiol Infect Dis 2007;26:857-868. https://doi.org/10.1007/s10096-007-0365-6
  2. Ho PL, Cheng VC, Chu CM. Antibiotic resistance in community-acquired pneumonia caused by Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, and Acinetobacter baumannii. Chest 2009;136:1119-1127. https://doi.org/10.1378/chest.09-0285
  3. Han SH, Na DJ, Yoo YW, et al. A case of probable community acquired acinetobacter baumannii pneumonia. Tuberc Respir Dis 2007;63:273-277. https://doi.org/10.4046/trd.2007.63.3.273
  4. Koprnova J, Svetlansky I, Babel'a R, et al. Prospective study of antibacterial susceptibility, risk factors and outcome of 157 episodes of Acinetobacter baumannii bacteremia in 1999 in Slovakia. Scand J Infect Dis 2001;33:891-895. https://doi.org/10.1080/00365540110076688
  5. Olut AI, Erkek E. Early prosthetic valve endocarditis due to Acinetobacter baumannii: a case report and brief review of the literature. Scand J Infect Dis 2005;37:919-921. https://doi.org/10.1080/00365540500262567
  6. Li JS, Sexton DJ, Mick N, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000;30:633-638. https://doi.org/10.1086/313753
  7. Clinical and Laboratory Standards Institute: Performance standards for antimicrobial susceptibility testing: 16th informational supplement document M100-S16. CLSI/NCCLS M100-S16. Wayne, PA: Clinical and Laboratory Standards Institute, 2006.
  8. Poirel L, Bercot B, Millemann Y, Bonnin RA, Pannaux G, Nordmann P. Carbapenemase-producing Acinetobacter spp. in Cattle, France. Emerg Infect Dis 2012;18:523-525. https://doi.org/10.3201/eid1803.111330
  9. Bhagan-Bruno S, Lather N, Fergus IV. Acinetobacter endocarditis presenting as a large right atrial mass: an atypical presentation. Echocardiography 2010;27:E39-E42. https://doi.org/10.1111/j.1540-8175.2009.01127.x
  10. Rasmussen RV. Anticoagulation in patients with stroke with infective endocarditis is safe. Stroke 2011;42:1795-1796. https://doi.org/10.1161/STROKEAHA.110.611681
  11. Gradon JD, Chapnick EK, Lutwick LI. Infective endocarditis of a native valve due to Acinetobacter: case report and review. Clin Infect Dis 1992;14:1145-1148. https://doi.org/10.1093/clinids/14.5.1145
  12. Rizos I, Tsiodras S, Papathanasiou S, Rigopoulos A, Barbetseas J, Stefanadis C. Prosthetic valve endocarditis due to Acinetobacter spp: a rare case and literature review. Am J Med Sci 2007;333:197-199. https://doi.org/10.1097/MAJ.0b013e31803193c4
  13. Menon T, Shanmugasundaram S, Nandhakumar B, Nalina K, Balasubramaniam. Infective endocarditis due to Acinetobacter baumannii complex: a case report. Indian J Pathol Microbiol 2006;49:576-578.
  14. Zeana C, Larson E, Sahni J, Bayuga SJ, Wu F, Della-Latta P. The epidemiology of multidrug-resistant Acinetobacter baumannii: does the community represent a reservoir? Infect Control Hosp Epidemiol 2003;24:275-279. https://doi.org/10.1086/502209