The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Successful Erythropoietin Therapy after Alemtuzumab and Cyclosporin a Treatment for Epoetin-Induced Pure Red Cell Aplasia

Alemtuzumab을 이용한 이차성 순적혈구 빈혈의 치료

  • Park, Hyemin (Division of Hematology and Hematological Malignancies, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Im, Jaeuk (Division of Hematology and Hematological Malignancies, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Park, Juhwan (Division of Hematology and Hematological Malignancies, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Kim, Enhye (Division of Hematology and Hematological Malignancies, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Jun, Honggil (Division of Hematology and Hematological Malignancies, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Park, Jae-Hoo (Division of Hematology and Hematological Malignancies, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Kim, Hawk (Division of Hematology and Hematological Malignancies, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
  • 박혜민 (울산대학교 의과대학 울산대학교병원 혈액내과) ;
  • 임재욱 (울산대학교 의과대학 울산대학교병원 혈액내과) ;
  • 박주환 (울산대학교 의과대학 울산대학교병원 혈액내과) ;
  • 김은혜 (울산대학교 의과대학 울산대학교병원 혈액내과) ;
  • 전홍길 (울산대학교 의과대학 울산대학교병원 혈액내과) ;
  • 박재후 (울산대학교 의과대학 울산대학교병원 혈액내과) ;
  • 김혁 (울산대학교 의과대학 울산대학교병원 혈액내과)
  • Received : 2012.11.13
  • Accepted : 2013.02.12
  • Published : 2013.08.01
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Abstract

Pure red cell aplasia (PRCA) in adults is usually idiopathic, although some underlying conditions can cause PRCA. Immunosuppressive therapy (IST) is used to treat PRCA, but IST has side effects and may fail. The anti-CD52 monoclonal antibody alemtuzumab (ALM) was recently used to successfully treat therapy-resistant PRCA. We herein report successful treatment of secondary PRCA after erythropoietin therapy using ALM and cyclosporin A (CsA) in one patient. The total dose of ALM was 60 mg over 3 days (10, 20, and 30 mg, respectively) plus CsA for at least 6 months. The patient achieved a complete response 18 months after ALM-CsA treatment and his treatment could be changed to a different erythropoietin-stimulating agent.

Keywords

References

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