The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Epigenetics in Allergic Diseases

후성유전과 알레르기 질환

  • Jang, An-Soo (Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital)
  • 장안수 (순천향대학교 부천병원 호흡기알레르기내과)
  • Published : 2013.09.01
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Abstract

The epigenetics is the study of changes in gene expression or celluar phenotype caused by mechanisms other than changes in the underlying DNA sequence. Epigenetic regulation in asthma and allergic diseases is an interesting area that has obtained a great deal of scientific concern in recent years. Allergic diseases such as asthma and allergic rhinitis in early life are one of the important indicators that the developing immune system is vulnerable to biologic and environmental pollutants. The epigenetic studies are likely to provide clear and deep understandings into how the environment can be modified to drive immune development and change the allergic disease phenotypes. This review includes 1) definition of epigenetics 2) regulation of epigenetics 3) characterization of environmental asthma and allergic diseases triggers that induce epigenetic changes.

Keywords

References

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