Journal of the Korean Society of Industry Convergence (한국산업융합학회 논문집)

The Korean Society of Industry Convergence (한국산업융합학회)
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Theoretical Study for the Characteristics of Finasteride

피나스테라이드의 특성에 대한 이론적 연구

  • Lee, Chul-Jae (School of Chemical Industry, Yeungnam College of Science & Technology) ;
  • Jung, Maeng-Joon (Department of Chemical Engineering, Kyungpook National University) ;
  • Kim, Dong-Yeub (School of Chemical Industry, Yeungnam College of Science & Technology)
  • 이철재 (영남이공대학 화장품.화공학부) ;
  • 정맹준 (경북대학교 나노소재공학부) ;
  • 김동엽 (영남이공대학 화장품.화공학부)
  • Received : 2013.07.18
  • Accepted : 2012.08.23
  • Published : 2013.08.31
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Abstract

Finasteride, ($5{\alpha}$, $17{\beta}$)-N-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide), is a 5a-reductase enzyme inhibitor. This enzyme converts testosterone to the more potent androgen, a-dihydrotestosterone. This molecules a logical medical treatment for benign prostatic hyperplasia (BPH), as it induced a reduction in serum dihydrotestosterone and prostatic specific antigen levels with a concomittant increase in blood testosterone concentration . Despite its widespread use, little has been published concerning its molecular properties. Therefore, in this study, in order to explain characteristics of finasteride, total energy, net charge, vibrational mode of melatonin are calculated by PM3 methods of HyperCam 8.0.

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