The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The Effect of Femented Platycodon grandiflorum on the Memory Impairment of Mice

발효에 의한 길경추출물의 인지기능 개선 효능

  • Kim, Tae-Yeon (Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology) ;
  • Shin, Yong-Wook (Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology)
  • 김태연 (경남과학기술대학교 농학.한약자원학부) ;
  • 신용욱 (경남과학기술대학교 농학.한약자원학부)
  • Received : 2013.03.06
  • Accepted : 2013.03.21
  • Published : 2013.03.30
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Abstract

Objectives : The purpose of this study was to characterize the effect of the Ethanolic extracts of Platycodon grandiflorum and its permented production the learning and memory impairments induced by scopolamine. Methods : The cognition-enhancing effect of Platycodon grandiflorum and its permented production were investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : The results showed that the Permented Platycodon grandiflorum extract-treated group (100 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Water maze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. Conclusions : These results suggest that 80% Ethanol extract of fermented P.grandiflorum showed significant anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent of the learning models.

Keywords

References

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