Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Experimental Equine Laminitis Induced by Treatment with Oligofructose

올리고당 투여를 통한 급성 제엽염의 실험적 유발

  • Kwon, Mi-Young (Laboratories of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Ryu, Doug-Young (Environmental Health and Biomarkers, College of Veterinary Medicine, Seoul National University) ;
  • Jeon, Hyung-Seon (Korea Racing Authority) ;
  • Kim, Joon-Gyu (Korea Racing Authority) ;
  • Cui, FengJi (Laboratories of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Seung-Woo (Environmental Health and Biomarkers, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Yongbaek (Laboratories of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University)
  • 권미영 (서울대학교 수의과대학 임상병리학) ;
  • 류덕영 (서울대학교 수의과대학 환경위생학) ;
  • 전형선 (한국마사회) ;
  • 김준규 (한국마사회) ;
  • 최봉희 (서울대학교 수의과대학 임상병리학) ;
  • 이승우 (서울대학교 수의과대학 환경위생학) ;
  • 김용백 (서울대학교 수의과대학 임상병리학)
  • Accepted : 2013.02.21
  • Published : 2013.02.28
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Abstract

Laminitis is a common horse disease that causes pain and disability. One of the major causes of laminitis is carbohydrate overload, which leads to the overgrowth of gram-positive bacteria and subsequent toxemia. This study was performed to establish an experimental model of acute phase laminitis. A horse was fed with a bolus dose of oligofructose, examined for clinical signs and blood parameters, and euthanized for necropsy and histopathology. After administration, the horse exhibited clinical signs including watery feces, inappetence, severe lameness, pyrexia and tachycardia. Complete blood count showed increased hematocrit, lymphocytosis and neutropenia. Serum chemistry revealed hyperglycemia, hyperproteinemia, high level of glutamic oxalate transaminase, creatinine, uric acid and mild hyponatremia. Histologically, the lamina tissue was edematous with mild infiltration of inflammatory cells. These findings indicate that oligofructose-induced laminitis in horse is an appropriate model for studying pathogenesis of acute phase laminitis.

Keywords

References

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