한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제30권1호
  • /
  • Pages.61-65
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  • 2013
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

개에서 발생한 전신성 낙엽상 천포창에 사람 면역글로불린의 임상적 적용

Clinical Trial of Human Intravenous Immunoglobulin in a Dog with Generalized Pemphigus Foliaceus

  • 박성준 (충남대학교 수의과대학.동물의과학연구소)
  • Park, Seong-Jun (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University)
  • 심사 : 2013.02.12
  • 발행 : 2013.02.28
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초록

An American Cocker Spaniel (3-year-old, intact female, 6.0 kg) was referred to the Veterinary Medical Teaching Hospital of Chungnam National University for evaluation of pustules and crusts in the periocular region, dorsal and ventral region of the trunk, and digits. Complete blood count (CBC) revealed leukocytosis with mature neutrophilia, and a serum biochemistry profile revealed hypoalbuminemia. Tape strip tests identified numerous neutrophils and acatholytic cells. Histopathology identified intraepithelial pustules with neutrophils and acantholytic keratinocytes. Definitive diagnosis of pemphigus foliaceus (PF) was made by direct immunofluorescence (DIF) test with goat anti-canine IgG antibody. The human intravenous immunoglobulin (IVIG) was administered at a rate of 15 ml/h over 6 hours for 4 days. After that, the dog was maintained on prednisolone (2.2 mg/kg, PO, SID) and azathioprine (2.0 m/kg, PO, SID). An infusion of IVIG (0.5 g/kg) was repeated 3 days after 4 weeks. After 10 weeks, the dog showed the remarkable regression of lesions.

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참고문헌

  1. Ahmed AR, Dahl MV. Consensus statement on the use of intravenous immunoglobulin therapy in the treatment of autoimmune mucocutaneous blistering diseases. Arch Dermatol 2003; 139: 1051-1059.
  2. Bayry J, Thirion M, Misra N, Thorenoor N, Delignat S, Lacroix-Desmazes S, Bellon B, Kaveri S, Kazatchkine MD. Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases. Neurol Sci 2003; 24: S217-S221. https://doi.org/10.1007/s10072-003-0138-7
  3. Bianco D, Armstrong PJ, Washabau RJ. Treatment of Severe Immune-Mediated Thrombocytopenia with Human IV Immunoglobulin in 5 Dogs. J Vet Intern Med 2007; 21: 694-699. https://doi.org/10.1111/j.1939-1676.2007.tb03010.x
  4. Durandy A, Kaveri SV, Kuipers TW, Basta M, Miescher S, Ravetch JV, Rieben R. Intravenous immunoglobulins - understanding properties and mechanisms. Clin Exp Immunol 2009; 158: 2-13. https://doi.org/10.1111/j.1365-2249.2009.04022.x
  5. Ihrke PJ, Stannard AA, Ardans AA, Griffin CE. Pemphigus foliaceus in dogs: A review of 37 cases. J Am Vet Med Assoc 1985; 186: 59-66.
  6. Jubb, Kennedy, Palmer. In: Pathology of Domestic Animals, 5th ed. Philadelphia: Saunders. 2007: 647-650.
  7. Kuhl KA, Shofer FS, Goldschmidt MH. Comparative Histopathology of Pemphigus Foliaceus and Superficial Folliculitis in the Dog. Vet Pathol 1994; 31: 19-27. https://doi.org/10.1177/030098589403100103
  8. Mueller RS, Krebs I, Power HT. Pemphigus foliaceus in 91 dogs. J Am Anim Hosp Assoc 2006; 42: 189-197. https://doi.org/10.5326/0420189
  9. Rahilly LJ, Keating JH, O'Toole TE. The Use of Intravenous Human Immunoglobulin in Treatment of Severe Pemphigus Foliaceus in a Dog. J Vet Intern Med 2006; 20: 1483-1486. https://doi.org/10.1111/j.1939-1676.2006.tb00770.x
  10. Rosenkrantz WS. Pemphigus: current therapy. Vet Dermatol 2004; 15: 90-98. https://doi.org/10.1111/j.1365-3164.2004.00360.x
  11. Ryan ME, Webster ML, Statlrt JD. Adverse effects of intravenous immunoglobulin therapy. Clin Pediatr 1996; 35: 23-31. https://doi.org/10.1177/000992289603500105
  12. Scott DW, Miller WH, Griffin CE. Immune-mediated disorders. In: Muller & Kirk's Small Animal Dermatology, 6th ed. Philadelphia: Saunders. 2001: 686-690.