개에서 발생한 전신성 낙엽상 천포창에 사람 면역글로불린의 임상적 적용

Clinical Trial of Human Intravenous Immunoglobulin in a Dog with Generalized Pemphigus Foliaceus

  • 박성준 (충남대학교 수의과대학.동물의과학연구소)
  • Park, Seong-Jun (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University)
  • 심사 : 2013.02.12
  • 발행 : 2013.02.28

초록

An American Cocker Spaniel (3-year-old, intact female, 6.0 kg) was referred to the Veterinary Medical Teaching Hospital of Chungnam National University for evaluation of pustules and crusts in the periocular region, dorsal and ventral region of the trunk, and digits. Complete blood count (CBC) revealed leukocytosis with mature neutrophilia, and a serum biochemistry profile revealed hypoalbuminemia. Tape strip tests identified numerous neutrophils and acatholytic cells. Histopathology identified intraepithelial pustules with neutrophils and acantholytic keratinocytes. Definitive diagnosis of pemphigus foliaceus (PF) was made by direct immunofluorescence (DIF) test with goat anti-canine IgG antibody. The human intravenous immunoglobulin (IVIG) was administered at a rate of 15 ml/h over 6 hours for 4 days. After that, the dog was maintained on prednisolone (2.2 mg/kg, PO, SID) and azathioprine (2.0 m/kg, PO, SID). An infusion of IVIG (0.5 g/kg) was repeated 3 days after 4 weeks. After 10 weeks, the dog showed the remarkable regression of lesions.

키워드

참고문헌

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