Radiation Oncology Journal

  • 제31권4호
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  • Pages.216-221
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  • 2013
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
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Short-course palliative radiotherapy for uterine cervical cancer

  • Kim, Dong Hyun (Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital) ;
  • Lee, Ju Hye (Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital) ;
  • Ki, Yong Kan (Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital) ;
  • Nam, Ji Ho (Department of Radiation Oncology, Pusan National University Yangsan Hospital) ;
  • Kim, Won Taek (Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital) ;
  • Jeon, Ho Sang (Department of Radiation Oncology, Pusan National University Yangsan Hospital) ;
  • Park, Dahl (Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital) ;
  • Kim, Dong Won (Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital)
  • 투고 : 2013.08.14
  • 심사 : 2013.11.12
  • 발행 : 2013.12.31
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초록

Purpose: The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Materials and Methods: Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. Results: The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Conclusion: Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

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참고문헌

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피인용 문헌

  1. Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients vol.10, pp.None, 2015, https://doi.org/10.1186/s13014-015-0373-0
  2. Aberrant Expression of Osteopontin and E-Cadherin Indicates Radiation Resistance and Poor Prognosis for Patients with Cervical Carcinoma vol.63, pp.2, 2013, https://doi.org/10.1369/0022155414561329
  3. Progestin-releasing intrauterine device insertion plus palliative radiotherapy in frail, elderly uterine cancer patients unfit for radical treatment vol.11, pp.5, 2016, https://doi.org/10.3892/ol.2016.4390
  4. Palliative external beam radiotherapy for the treatment of tumor bleeding in inoperable advanced gastric cancer vol.17, pp.None, 2017, https://doi.org/10.1186/s12885-017-3508-x
  5. National Cancer Grid of India Consensus Guidelines on the Management of Cervical Cancer vol.4, pp.None, 2013, https://doi.org/10.1200/jgo.17.00152
  6. Short-course palliative radiation therapy leads to excellent bleeding control: A single centre retrospective study vol.14, pp.None, 2013, https://doi.org/10.1016/j.ctro.2018.11.007
  7. Patterns of practice in palliative radiotherapy for bleeding tumours in the Netherlands; a survey study among radiation oncologists vol.15, pp.None, 2013, https://doi.org/10.1016/j.ctro.2019.01.004
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  14. Retrospective review of 37.4 Gy in 11 fractions for the palliation of advanced cervical cancer vol.13, pp.1, 2013, https://doi.org/10.1080/20742835.2021.1991099