Parasites, Hosts and Diseases

  • 제51권6호
  • /
  • Pages.767-769
  • /
  • 2013
  • /
  • 2982-5164(pISSN)
  • /
  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
권호 표지
DOI QR코드

DOI QR Code

High Prevalence of Haplorchiasis in Nan and Lampang Provinces, Thailand, Proven by Adult Worm Recovery from Suspected Opisthorchiasis Cases

  • 투고 : 2013.05.30
  • 심사 : 2013.10.11
  • 발행 : 2013.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Opisthorchiasis, a risk factor for cholangiocarcinoma in humans, is of public health importance in Thailand. The Annual Surveillance Reports from Nan and Lampang Provinces, Thailand, for the year 2011 showed an opisthorchiasis prevalence of over 70% by recovery of eggs in the feces. This study investigated whether most cases are actually due to minute intestinal flukes (MIF) rather than Opisthorchis viverrini, as the eggs of both can hardly be differentiated by morphology. Fifty and 100 cases from residents in Nan and Lampang, respectively, had stools positive for eggs initially assumed to be those of O. viverrini. Each patient was given praziquantel at 40 mg/kg in a single dose. After 2 hr, 30-45 ml of the purgative magnesium sulfate was given, and stools were collected up to 4 times sequentially. The stools were examined for adult worms by simple sedimentation. It was found that 39 of 50 cases (78.0%) from Nan Province had Haplorchis taichui, with intensities ranging from 5 to 1,250 with an average of 62 worms/case. Taenia saginata (7 cases) and Enterobius vermicularis (1 case) were other helminths recovered as the co-infectants. In Lampang Province, H. taichui was recovered from 69 cases (69.0%). The number of flukes recovered ranged from 1 to 4,277, with an average of 326 worms/case. Four cases had Phaneropsolus bonnei, and 10 T. saginata as the co-infectants. Adult specimens of O. viverrini were not recovered from any stool. Clearly, MIF infection, especially haplorchiasis, is more common in northern Thailand. These findings should encourage the Public Health Office to employ more specific tools than Kato's method for surveillance of opisthorchiasis in Thailand.

키워드

참고문헌

  1. Fürst T, Keiser J, Utzinger J. Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. Lancet Infect Dis 2012; 12: 210-221. https://doi.org/10.1016/S1473-3099(11)70294-8
  2. Sithithaworn P, Andrews RH, Nguyen VD, Wongsaroj T, Sinuon M, Odermatt P, Nawa Y, Liang S, Brindley PJ, SripaB. The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitol Int 2012; 61: 10-16. https://doi.org/10.1016/j.parint.2011.08.014
  3. Kaewkes S, Elkins D, Sithithaworn P, Haswell-Elkins MR. Comparative studies on the morphology of the eggs of Opisthorchis viverrini and lechithodendriid trematodes. Southeast Asian J Trop Med Public Health 1991; 22: 623-630.
  4. Sukontason K, Piangjai S, Sukontasun K, Chaithong U. Potassium permanganate staining for differentiation of the surface morphology of Opisthorchis viverrini, Haplorchis taichui and Phaneropsolus bonnei eggs. Southeast Asian J Trop Med Public Health 1999; 30: 371-374.
  5. Tesana S, Srisawangwonk T, Kaewkes S, Sithithaworn P, Kanla P, Arunyanart C. Eggshell morphology of the small eggs of human trematodes in Thailand. Southeast Asian J Trop Med Public Health 1991; 22: 631-636.
  6. Pearson JC, Ow-Yang CK. New species of Haplorchis from Southeast Asia together with keys to the Haplorchis-group of heterophyid trematodes of the region. Southeast Asian J Trop Med Public Health 1982; 13: 35-60.
  7. Manning GS, Lertprasert P, Watanasirmkit K, Chetty C. A description of newly discovered intestinal parasites endemic to northeastern Thailand. J Med Assoc Thai 1971; 54: 466-474.
  8. Chaiyaporn V. Differentiation of pork and beef tapeworms by India ink injection into gravid proglottides. Siriraj Hosp Gaz 1972; 24: 1881-1886 (in Thai).
  9. Wongsawad C, Phalee A, Noikong W, Chuboon S, Nithikathkul C. Co-infection with Opisthorchis viverrini and Haplorchis taichui detected by human fecal examination in Chomtong district, Chiang Mai Province, Thailand. Parasitol Int 2012; 61: 56-59. https://doi.org/10.1016/j.parint.2011.10.003
  10. Waikagul J, Jongsuksantigul P, Rattanawitoon U, Radomyos P, Kojima S, Takeuchi T. Parasitological monitoring of helminth control program in northern Thailand. Southeast Asian J Trop Med Public Health 2008; 39: 1008-1014.
  11. Waikagul J, Krudsood S, Radomyos P, Radomyos B, Chalemrut K, Jonsuksuntigul P, Kojima S, Looareesuwan S, Thaineau W.A crosssectional study of intestinal parasitic infections among schoolchildren in Nan Province, Northern Thailand. Southeast Asian J Trop Med Public Health 2002; 33: 218-223.
  12. Chai JY, Yong TS, Eom KS, Min DY, Shin EH, Banouvong V, Insisiengmay B, Insisiengmay S, Phommasack B, Rim HJ. Prevalence of the intestinal flukes Haplorchis taichui and H. yokogawai in a mountainous area of Phongsaly Province, Lao PDR. Korean J Parasitol 2010; 48: 339-342. https://doi.org/10.3347/kjp.2010.48.4.339
  13. Chai JY, Yong TS, Eom KS, Min DY, Jeon HK, Kim TY, Jung BK, Sisabath L, Insisiengmay B, Phommasack B, Rim HJ. Hyperendemicity of Haplorchis taichui infection among riparian people in Saravane and Champasak province, Lao PDR. Korean J Parasitol 2013; 51: 305-311. https://doi.org/10.3347/kjp.2013.51.3.305
  14. Watthanakulpanich D, Waikagul J, Maipanich W, Nuamtanong S, Sanguankiat S, Pubampen S, Praevanit R, Mongkhonmu S, Nawa Y. Haplorchis taichui as a possible etiologic agent of irritable bowel syndrome-like symptoms. Korean J Parasitol 2010; 48: 225-259. https://doi.org/10.3347/kjp.2010.48.3.225

피인용 문헌

  1. Fishborne zoonotic heterophyid infections: An update vol.8, pp.None, 2013, https://doi.org/10.1016/j.fawpar.2017.09.001
  2. Molecular discrimination of Opisthorchis -like eggs from residents in a rural community of central Thailand vol.11, pp.11, 2017, https://doi.org/10.1371/journal.pntd.0006030
  3. Parasitic infections in relation to practices and knowledge in a rural village in Northern Thailand with emphasis on fish-borne trematode infection vol.147, pp.None, 2013, https://doi.org/10.1017/s0950268818002996
  4. Adenosine Suppresses Cholangiocarcinoma Cell Growth and Invasion in Equilibrative Nucleoside Transporters-Dependent Pathway vol.21, pp.3, 2020, https://doi.org/10.3390/ijms21030814
  5. Intestinal parasites in rural communities in Nan Province, Thailand: changes in bacterial gut microbiota associated with minute intestinal fluke infection vol.147, pp.9, 2013, https://doi.org/10.1017/s0031182020000736
  6. Genetic Differentiation of Opisthorchis-Like Eggs in Northern Thailand Using Stool Specimens Under National Strategic Plan to Control Liver Fluke Infection and Cholangiocarcinoma vol.103, pp.3, 2013, https://doi.org/10.4269/ajtmh.20-0231
  7. Model-based spatial-temporal mapping of opisthorchiasis in endemic countries of Southeast Asia vol.10, pp.None, 2013, https://doi.org/10.7554/elife.59755