Parasites, Hosts and Diseases

  • 제51권6호
  • /
  • Pages.759-761
  • /
  • 2013
  • /
  • 2982-5164(pISSN)
  • /
  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
권호 표지
DOI QR코드

DOI QR Code

Successful Treatment of Brugia pahangi in Naturally Infected Cats with Ivermectin

  • Taweethavonsawat, Piyanan (Parasitology Unit, Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University) ;
  • Chungpivat, Sudchit (Parasitology Unit, Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University)
  • 투고 : 2013.05.30
  • Accepted : 2013.10.11
  • Published : 2013.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

Abstract

Lymphatic filariasis is a common parasitic disease of cats in tropical regions including Thailand. The objective of this study was to determine the efficacy of ivermectin against microfilariae of Brugia pahangi in naturally infected cats. Eight cats naturally infected with B. pahangi were divided into control (untreated) and treated groups. Cats in the latter group were given ivermectin injection at 400 ${\mu}g/kg$ weekly for 2 months. Microfilariae were counted every week until 48 weeks. Microfilaremia was significantly decreased in the treated group 4 weeks after starting the treatment and become zero at week 9 and afterwards. On the other hand, cats in the control group had high microfilaremia throughout the study. It was successful to treat and control B. pahangi infection in naturally infected cats using ivermectin.

Keywords

References

  1. Phantana S, Sarataphan N, Chansiri G, Chansiri K. Microfilaricidal efficacy of ivermectin on zoonotic Brugia malayi in naturally infected cats. J Trop Med Parasitol 2002; 25: 11-16.
  2. Junhom W, Chungpivat S, Visseshakul N. The observation of microfilaria rate and density in cats inoculated with increasing numbers of Brugia pahangi infective larvae. Southeast Asian J Trop Med Public Health 2006; 37(suppl 3): 40-42.
  3. Chungpivat S, Sucharit S. Microfilariae in cats in Bangkok. Thai J Vet Med 1993; 23: 75-87.
  4. Tompkins JB, Stitt LE, Ardelli BF. Brugia malayi: in vitro effects of ivermectin and moxidectin on adults and microfilariae. Exp Parasitol 2010; 124: 394-402. https://doi.org/10.1016/j.exppara.2009.12.003
  5. Speare R, Durrheim D. Mass treatment with ivermectin: an underutilized public health strategy. Bulletin of WHO 2004; 82: 562.
  6. Bottomley C, Isham V, Collins RC, Basanez MG. Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments. Parasitology 2008; 135: 1571-1581. https://doi.org/10.1017/S0031182008000425
  7. McCall JW, Genchi C, Kramer L, Guerrero J, Dzimianski MT, Supakorndej P, Mansour AM, McCall SD, Supakorndej N, Grandi G, Carson B. Heartworm and Wolbachia: therapeutic implications. Vet Parasitol 2008; 158: 204-214. https://doi.org/10.1016/j.vetpar.2008.09.008
  8. Stolk WA, Van Ootmarssen GJ, Pani SP, De Vlas SJ, Subramanian S, Das PK, Habbema JD. Effects of ivermectin and diethylcabamazine on microfilariae and overall microfilaria production in bancroftian filariasis. Am J Trop Med Hyg 2005; 73: 881-887.
  9. Tagboto SK, Townson S. Onchocerca volvulus and O. lienalis: the microfilaricidal activity of moxidectin compared with that of ivermectin in vitro and in vivo. Ann Trop Med Parasitol 1996; 90: 497-505.
  10. Chansiri G, Khawsak P, Phantana S, Sarataphan N, Chansiri K. The efficacy of a single-oral-dose administration of ivermectin and diethylcarbamazine on the treatment of feline Brugia malayi. Southeast Asian J Trop Med Public Health 2005; 36: 1105-9.
  11. Chungpivat S, Taweethavonsawat P. The differentiation of microfilariae in dogs and cats using Giemsa's staining and the detection of acid phosphatase activity. J Thai Vet Prac 2008; 20: 47-55.
  12. Lachin JM. Some large-sample distribution-free estimators and tests for multivariate partially incomplete data from two populations. Stat Med 1992; 11: 1151-1170. https://doi.org/10.1002/sim.4780110903
  13. Thall PF, Lachin JM. Analysis of recurrent events: nonparametric methods for random interval count data. J Am Stat Assoc 1988; 83: 339-347. https://doi.org/10.1080/01621459.1988.10478603
  14. Baird JK, Riberu W, Masbar S, Purnomo. Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. J Parasitol 1991; 77: 162-163. https://doi.org/10.2307/3282575
  15. Campbell WC. Efficacy of the avermectins against filarial parasites: a short review. Vet Res Commun. 1982; 5: 252-62.
  16. Mancebo OA, Verdi JH, Bulman GM. Comparative efficacy of moxidectin 2% equine oral gel and ivermectin 2% equine oral paste against Onchocerca cervicalis (Railiet and Henry. 1910) microfilariae in horses with naturally acquired infections in Formosa (Argentina). Vet Parasitol 1997; 73: 243-248. https://doi.org/10.1016/S0304-4017(97)00136-2

Cited by

  1. Comparison of efficacy of ivermectin and diethylcarbamazine against naturally infected Brugia malayi microfilaria in dogs vol.43, pp.4, 2013, https://doi.org/10.1007/s12639-019-01126-2
  2. Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma vol.80, pp.None, 2021, https://doi.org/10.1016/j.parint.2020.102203