Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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A Case of Vivax Malaria Complicated by Adult Respiratory Distress Syndrome and Successful Management with Extracorporeal Membrane Oxygenation

  • Lee, Hyun-Jung (Department of Internal Medicine, Inha University School of Medicine) ;
  • Baek, Ji-Hyeon (Department of Internal Medicine, Inha University School of Medicine) ;
  • Chae, Myoung-Hun (Department of Internal Medicine, Inha University School of Medicine) ;
  • Joo, Hoyeon (Department of Internal Medicine, Inha University School of Medicine) ;
  • Lee, Jin-Soo (Department of Internal Medicine, Inha University School of Medicine) ;
  • Chung, Moon-Hyun (Department of Internal Medicine, Inha University School of Medicine) ;
  • Park, Yun-Kyu (Department of Parasitology, Inha University School of Medicine) ;
  • Kim, Joung-Teak (Department of Thoracic and Cardiovascular Surgery, Inha University School of Medicine)
  • Received : 2013.05.28
  • Accepted : 2013.08.21
  • Published : 2013.10.31
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Abstract

Complicated malaria is mainly caused by Plasmodium falciparum, but, increasingly, Plasmodium vivax is also being reported as a cause. Since the reemergence of indigenous vivax malaria in 1993, cases of severe malaria have been steadily reported in Korea. Herein, we report a case of vivax malaria complicated by adult respiratory distress syndrome (ARDS) that was successfully managed with extracorporeal membrane oxygenation (ECMO). A 59-year-old man presented at our hospital with fever and abdominal pain, which had persisted for 10 days. On admission, the patient had impaired consciousness, shock, hypoxia and haziness in both lungs, jaundice, thrombocytopenia and disseminated intravascular coagulation, metabolic acidosis, and acute kidney injury. A peripheral blood smear and a rapid diagnostic test verified P. vivax mono-infection. Ten hours after admission, hypoxia became more severe, despite providing maximal ventilatory support. The administration of antimalarial agents, ECMO, and continuous venovenous hemofiltration resulted in an improvement of his vital signs and laboratory findings. He was discharged from the hospital 7 weeks later, without any sequelae.

Keywords

References

  1. World Health Organization. Management of severe malaria: a practical handbook. 3rd ed. Geneva, Switzerland. WHO Press. 2012, p 1-68.
  2. Anstey NM, Douglas NM, Poespoprodjo JR, Price RN. Plasmodium vivax: clinical spectrum, risk factors and pathogenesis. Adv Parasitol 2012; 80: 151-201. https://doi.org/10.1016/B978-0-12-397900-1.00003-7
  3. Tjitra E, Anstey NM, Sugiarto P, Warikar N, Kenangalem E, Karyana M, Lampah DA, Price RN. Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia. PLoS Med 2008; 5: e128. https://doi.org/10.1371/journal.pmed.0050128
  4. Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MV, del Portillo HA, Araujo MO, Russell B, Suwanarusk R, Snounou G, Renia L, Costa FT. On the cytoadhesion of Plasmodium vivax-infected erythrocytes. J Infect Dis 2010; 202: 638-647. https://doi.org/10.1086/654815
  5. Lacerda MV, Fragoso SC, Alecrim MG, Alexandre MA, Magalhães BM, Siqueira AM, Ferreira LC, Araujo JR, Mourão MP, Ferrer M, Castillo P, Martin-Jaular L, Fernandez-Becerra C, del Portillo H, Ordi J, Alonso PL, Bassat Q. Postmortem characterization of patients with clinical diagnosis of Plasmodium vivax malaria: to what extent does this parasite kill? Clin Infect Dis 2012; 55: e67-74. https://doi.org/10.1093/cid/cis288
  6. Chae JY. Re-emerging Plasmodium vivax malaria in the Republic of Korea. Korean J Parasitol 1999; 37: 129-143. https://doi.org/10.3347/kjp.1999.37.3.129
  7. Park SW, Kim DW, Park JW, Lee SI, Shin YH, Kim EC, Oh MD, Choe KW. A case of fatal Plasmodium vivax malaria with multiorgan failure. Infect Chemother 2005; 37: 111-115.
  8. Song JY, Park CW, Jo YM, Kim JY, Kim JH, Yoon HJ. Two cases of Plasmodium vivax malaria with the clinical picture resembling toxic shock. Am J Trop Med Hyg 2007; 77: 609-611.
  9. Yoon SG, Kim MH, Jung ES, Han KH, Kwak YG, Cho CR, Um TH, Kim ES. A case of vivax malaria with seizure and shock. Infect Chemother 2007; 39: 226-229.
  10. Kim HJ, Lee SH, Koo TY, Kim KM, Jang SS, Lee SK. A case of Plasmodium vivax malaria complicated with acute renal failure, jaundice and thrombocytopenia. Korean J Nephrol 2010; 29: 792-795.
  11. Shin DH, Kim KS, Kim YJ, Lee SH, Kim SJ, Cho CK, Shin JH, Ryang DW, Lee JH. A case of spontaneous splenic rupture in vivax malaria. Korean J Infect Dis 1999; 31: 176-179.
  12. Hemmila MR, Rowe SA, Boules TN, Miskulin J, McGillicuddy JW, Schuerer DJ, Haft JW, Swaniker F, Arbabi S, Hirschl RB, Bartlett RH. Extracorporeal life support for severe acute respiratory distress syndrome in adults. Ann Surg 2004; 240: 595-605.
  13. Neurath M, Benzing A, Knolle P, Grundmann H, Dippold W, Meyer zum Büschenfelde KH. Acute respiratory failure in tropical malaria during pregnancy. Successful treatment using extracorporeal CO2 elimination. Dtsch Med Wochenschr 1993; 118: 1060-1066. https://doi.org/10.1055/s-2008-1059426
  14. Vandroux D, Leaute B, Hoarau N, Ursulet L, Djouhri S, Braunberger E, Gaüzère BA. High frequency oscillation ventilation and extracorporeal membrane oxygenation during pernicious malaria. Med Mal Infect 2011; 41: 209-212. https://doi.org/10.1016/j.medmal.2010.11.001
  15. Andrade BB, Reis-Filho A, Souza-Neto SM, Clarencio J, Camargo LM, Barral A, Barral-Netto M. Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance. Malar J 2010; 9; 13. https://doi.org/10.1186/1475-2875-9-13
  16. Dondorp AM, Lee SJ, Faiz MA, Mishra S, Price R, Tjitra E, Than M, Htut Y, Mohanty S, Yunus EB, Rahman R, Nosten F, Anstey NM, Day NP, White NJ. The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis 2008; 47: 151-157. https://doi.org/10.1086/589287
  17. MacMullin G, Mackenzie R, Lau R, Khang J, Zhang H, Rajwans N, Liles WC, Pillai DR. Host immune response in returning travellers infected with malaria. Malar J 2012; 11: 148. https://doi.org/10.1186/1475-2875-11-148
  18. Supriya Sarkar, Kaushik Saha, and Chandra Sekhar Das. Three cases of ARDS: an emerging complication of Plasmodium vivax malaria. Lung India 2010; 27: 154-157. https://doi.org/10.4103/0970-2113.68323
  19. Lacerda MV, Mourao MP, Alexandre MA, Siqueira AM, Magalhaes BM, Martinez-Espinosa FE, Filho FS, Brasil P, Ventura AM, Tada MS, Couto VS, Silva AR, Silva RS, Alecrim MG. Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature. Malar J 2012; 11: 12. https://doi.org/10.1186/1475-2875-11-12
  20. Buck ML. Pharmacokinetic changes during extracorporeal membrane oxygenation: implications for drug therapy of neonates. Clin Pharmacokinet 2003; 42: 403-417. https://doi.org/10.2165/00003088-200342050-00001

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