References
- Rasouli N, Molavi B, Elbein SC, Kern PA. Ectopic fat accumulation and metabolic syndrome. Diabetes Obes Metab. 2007;9:1-10.
- Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes. 1995;44:863-870.
- Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH. Protection against lipoapoptosis of beta cells through leptindependent maintenance of Bcl-2 expression. Proc Natl Acad Sci USA. 1998;95:9558-9561. https://doi.org/10.1073/pnas.95.16.9558
- Unger RH, Orci L. Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta. 2002;1585:202-212. https://doi.org/10.1016/S1388-1981(02)00342-6
- Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE. Diabetes and apoptosis: lipotoxicity. Apoptosis. 2009;14:1484- 1495. https://doi.org/10.1007/s10495-009-0352-8
- Mu YM, Yanase T, Nishi Y, Tanaka A, Saito M, Jin CH, Mukasa C, Okabe T, Nomura M, Goto K, Nawata H. Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology. 2001;142:3590-3597. https://doi.org/10.1210/endo.142.8.8293
- Eitel K, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Haring HU, Kellerer M. Different role of saturated and unsaturated fatty acids in beta-cell apoptosis. Biochem Biophys Res Commun. 2002;299:853-856. https://doi.org/10.1016/S0006-291X(02)02752-3
- Akazawa Y, Cazanave S, Mott JL, Elmi N, Bronk SF, Kohno S, Charlton MR, Gores GJ. Palmitoleate attenuates palmitateinduced Bim and PUMA up-regulation and hepatocyte lipoapoptosis. J Hepatol. 2010;52:586-593. https://doi.org/10.1016/j.jhep.2010.01.003
- Suzuki J, Akahane K, Nakamura J, Naruse K, Kamiya H, Himeno T, Nakamura N, Shibata T, Kondo M, Nagasaki H, Fujiya A, Oiso Y, Hamada Y. Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways. Neuroscience. 2011;176:188-198. https://doi.org/10.1016/j.neuroscience.2010.11.035
- Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab. 2006;291:E1341-1350. https://doi.org/10.1152/ajpendo.00095.2006
- Cazanave SC, Elmi NA, Akazawa Y, Bronk SF, Mott JL, Gores GJ. CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis. Am J Physiol Gastrointest Liver Physiol. 2010;299:G236-243. https://doi.org/10.1152/ajpgi.00091.2010
- Soumura M, Kume S, Isshiki K, Takeda N, Araki S, Tanaka Y, Sugimoto T, Chin-Kanasaki M, Nishio Y, Haneda M, Koya D, Kashiwagi A, Maegawa H, Uzu T. Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell. Biochem Biophys Res Commun. 2010;402:265-271. https://doi.org/10.1016/j.bbrc.2010.10.012
- Yuzefovych L, Wilson G, Rachek L. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab. 2010;299:E1096-1105. https://doi.org/10.1152/ajpendo.00238.2010
- Kovanlikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantification in lean tissues using three-point Dixon MR imaging. Pediatr Radiol. 2005;35:601-607. https://doi.org/10.1007/s00247-005-1413-y
- Yan MX, Li YQ, Meng M, Ren HB, Kou Y. Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia. Biochem Biophys Res Commun. 2006;347:192-199. https://doi.org/10.1016/j.bbrc.2006.06.063
- Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes. 2001;50:1771-1777. https://doi.org/10.2337/diabetes.50.8.1771
- Gumbs AA. Obesity, pancreatitis, and pancreatic cancer. Obes Surg. 2008;18:1183-1187. https://doi.org/10.1007/s11695-008-9599-3
- Habara Y, Uehara A, Takasugi Y, Namiki M, Kanno T. Characterization of secretory responses in exocrine pancreas of genetically obese Zucker rats. Int J Pancreatol. 1991;10:237-245.
- Hardt PD, Krauss A, Bretz L, Porsch-Ozcurumez M, Schnell- Kretschmer H, Mser E, Bretzel RG, Zekhorn T, Klör HU. Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus. Acta Diabetol. 2000;37:105-110. https://doi.org/10.1007/s005920070011
- Ammann RW, Raimondi S, Maisonneuve P, Mullhaupt B. Zurich Pancreatitis Study Group. Is obesity an additional risk factor for alcoholic chronic pancreatitis? Pancreatology. 2010; 10:47-53. https://doi.org/10.1159/000225921
- Landau Z, Forti E, Alcaly M, Birk RZ. Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells. Apoptosis. 2006;11:717-724. https://doi.org/10.1007/s10495-006-5425-3
- Spector AA. Fatty acid binding to plasma albumin. J Lipid Res. 1975;16:165-179.
- Park YH, Kim YJ, Son IH, Yang HD. Inhibition of betaamyloid( 1-40) Peptide Aggregation and Neurotoxicity by Citrate. Korean J Physiol Pharmacol. 2009;13:273-279. https://doi.org/10.4196/kjpp.2009.13.4.273
- Hirasawa A, Hara T, Katsuma S, Adachi T, Tsujimoto G. Free fatty acid receptors and drug discovery. Biol Pharm Bull. 2008;31:1847-1851. https://doi.org/10.1248/bpb.31.1847
- Chavez JA, Summers SA. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys. 2003;419:101-109. https://doi.org/10.1016/j.abb.2003.08.020
- Azevedo-Martins AK, Monteiro AP, Lima CL, Lenzen S, Curi R. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. Toxicol In Vitro. 2006;20: 1106-1113. https://doi.org/10.1016/j.tiv.2006.02.007
- Otsuki M, Yamamoto M, Yamaguchi T. Animal models of chronic pancreatitis. Gastroenterol Res Pract. 2010; ID 403295.
- Han MS, Park SY, Shinzawa K, Kim S, Chung KW, Lee JH, Kwon CH, Lee KW, Lee JH, Park CK, Chung WJ, Hwang JS, Yan JJ, Song DK, Tsujimoto Y, Lee MS. Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J Lipid Res. 2008;49:84-97. https://doi.org/10.1194/jlr.M700184-JLR200
- Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes. 2003;52:726-733. https://doi.org/10.2337/diabetes.52.3.726
- Masuoka HC, Mott J, Bronk SF, Werneburg NW, Akazawa Y, Kaufmann SH, Gores GJ. Mcl-1 degradation during hepatocyte lipoapoptosis. J Biol Chem. 2009;284:30039-30048. https://doi.org/10.1074/jbc.M109.039545
-
Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL, Cardozo AK. Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to
$\beta$ -cell apoptosis. Cell Death Differ. 2011;18:328-337. https://doi.org/10.1038/cdd.2010.105 - Coll T, Eyre E, Rodriguez-Calvo R, Palomer X, Sanchez RM, Merlos M, Laguna JC, Vazquez-Carrera M. Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J Biol Chem. 2008;283:11107-11116. https://doi.org/10.1074/jbc.M708700200
-
Nemcova-Furstova V, James RF, Kovar J. Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic
$\beta$ -cells: activation of caspases and ER stress induction. Cell Physiol Biochem. 2011;27:525-538. https://doi.org/10.1159/000329954 - Nolan CJ, Larter CZ. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it? J Gastroenterol Hepatol. 2009;24:703-706. https://doi.org/10.1111/j.1440-1746.2009.05823.x
- Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV Jr. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci USA. 1998;95:13018-13023. https://doi.org/10.1073/pnas.95.22.13018
- Oelkers P, Behari A, Cromley D, Billheimer JT, Sturley SL. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J Biol Chem. 1998;273:26765-26771. https://doi.org/10.1074/jbc.273.41.26765
- Jogl G, Tong L. Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. Cell. 2003;112:113-122. https://doi.org/10.1016/S0092-8674(02)01228-X
- Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV Jr. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 2004;279: 11767-11776. https://doi.org/10.1074/jbc.M311000200
- Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA. 2003; 100:3077-3082. https://doi.org/10.1073/pnas.0630588100
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