Annals of Clinical Neurophysiology

  • 제15권1호
  • /
  • Pages.34-36
  • /
  • 2013
  • /
  • 2508-691X(pISSN)
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  • 2508-6960(eISSN)
대한임상신경생리학회 (The Korean Society of Clinical Neurophysiology)
권호 표지

정상 신기능 환자에서 발생한 Acyclovir 유발 뇌병증

Acyclovir-Induced Encephalopathy in a Patient with Normal Renal Function

  • 이상길 (단국대학교 의과대학 단국대학교병원 신경과) ;
  • 윤일기 (단국대학교 의과대학 단국대학교병원 신경과) ;
  • 박정준 (단국대학교 의과대학 단국대학교병원 신경과) ;
  • 김재일 (단국대학교 의과대학 단국대학교병원 신경과) ;
  • 이근호 (단국대학교 의과대학 단국대학교병원 신경과) ;
  • 김지현 (단국대학교 의과대학 단국대학교병원 신경과)
  • Lee, Sangkil (Department of Neurology, Dankook University Hospital, Dankook University College of Medicine) ;
  • Yoon, Il-Gi (Department of Neurology, Dankook University Hospital, Dankook University College of Medicine) ;
  • Park, Jung-Jun (Department of Neurology, Dankook University Hospital, Dankook University College of Medicine) ;
  • Kim, Jae Il (Department of Neurology, Dankook University Hospital, Dankook University College of Medicine) ;
  • Lee, Geun-Ho (Department of Neurology, Dankook University Hospital, Dankook University College of Medicine) ;
  • Kim, Jee Hyun (Department of Neurology, Dankook University Hospital, Dankook University College of Medicine)
  • 투고 : 2012.12.21
  • 심사 : 2013.05.29
  • 발행 : 2013.06.30
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참고문헌

  1. Peces R, de la Torre M, Alcazar R. Acyclovir-associated encephalopathy in haemodialysis. Nephrol Dial Transplant 1996; 11:752.
  2. Revankar SG, Applegate AL, Markovitz DM. Delirium associated with acyclovir treatment in a patient with renal failure. Clin Infect Dis 1995;21:435-436. https://doi.org/10.1093/clinids/21.2.435
  3. Rashiq S, Briewa L, Mooney M, Giancarlo T, KhatibR, Wilson FM. Distinguishing acyclovir neurotoxicity from encephalomyelitis. J Intern Med 1993;234:507-511. https://doi.org/10.1111/j.1365-2796.1993.tb00785.x
  4. Laskin OL, Longstreth JA, Whelton A. Acyclovir kinetics in end-stage renal disease. Clin Pharmacol Ther 1982;31:594-601. https://doi.org/10.1038/clpt.1982.83
  5. Hellde´n A, Odar-Cederlof I, Diener P, Barkholt L, Medin C, Svensson JO, et al. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrol Dial Transplant 2003;18:1135-1141. https://doi.org/10.1093/ndt/gfg119
  6. Hellde´n A, Lycke J, Vander T, Svensson JO, Odar-Cederlof I, Stahle L. The acyclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during acyclovir and valaciclovir treatment. J Antimicrob Chemother 2006;57:945-949. https://doi.org/10.1093/jac/dkl067
  7. Smith JP, Weller S, Johnson B, Nicotera J, Luther JM, Haas DW. Pharmacokinetics of Acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function. Antimicrob Agents Chemother 2010;54:1146-1151. https://doi.org/10.1128/AAC.00729-09