Journal of Korean Neurosurgical Society

  • 제54권6호
  • /
  • Pages.461-466
  • /
  • 2013
  • /
  • 2005-3711(pISSN)
  • /
  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
권호 표지
DOI QR코드

DOI QR Code

Therapeutic Advantages of Treatment of High-Dose Curcumin in the Ovariectomized Rat

  • Cho, Dae-Chul (Department of Neurosurgery, School of Medicine, Kyungpook National University) ;
  • Jung, Hyun-Sik (Department of Neurosurgery, School of Medicine, Kyungpook National University) ;
  • Kim, Kyoung-Tae (Department of Neurosurgery, School of Medicine, Kyungpook National University) ;
  • Jeon, Younghoon (Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University) ;
  • Sung, Joo-Kyung (Department of Neurosurgery, School of Medicine, Kyungpook National University) ;
  • Hwang, Jeong-Hyun (Department of Neurosurgery, School of Medicine, Kyungpook National University)
  • 투고 : 2013.02.05
  • 심사 : 2013.12.12
  • 발행 : 2013.12.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective : Although curcumin has a protective effect on bone remodeling, appropriate therapeutic concentrations of curcumin are not well known as therapeutic drugs for osteoporosis. The purpose of this study was to compare the bone sparing effect of treatment of low-dose and high-dose curcumin after ovariectomy in rats. Methods : Forty female Sprague-Dawley rats underwent either a sham operation (the sham group) or bilateral ovariectomy (OVX). The ovariectomized animals were randomly distributed among three groups; untreated OVX group, low-dose (10 mg/kg) curcumin administered group, and high-dose (50 mg/kg) curcumin group. At 4 and 8 weeks after surgery, serum biochemical markers of bone turnover were analyzed. Bone histomorphometric parameters of the 4th lumbar vertebrae were determined by micro-computed tomography (CT). In addition, mechanical strength was determined by a three-point bending test. Results : High-dose curcumin group showed significantly lower osteocalcin, alkaline phosphatase, and the telopeptide fragment of type I collagen C-terminus concentration at 4 and 8 weeks compared with the untreated OVX group as well as low-dose curcumin group. In the analyses of micro-CT scans of 4th lumbar vertebrae, the high-dose curcumin treated group showed a significant increase in bone mineral densities (p=0.028) and cortical bone mineral densities (p=0.036) compared with the low-dose curcumin treated group. Only high-dose curcumin treated group had a significant increase of mechanical strength compared with the untreated OVX group (p=0.015). Conclusion : The present study results demonstrat that a high-dose curcumin has therapeutic advantages over a low-dose curcumin of an antiresorptive effect on bone remodeling and improving bone mechanical strength.

키워드

참고문헌

  1. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A : Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 22 : 465-475, 2007 https://doi.org/10.1359/jbmr.061113
  2. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, et al. : Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21 : 2895-2900, 2001
  3. Cho DC, Kim KT, Jeon Y, Sung JK : A synergistic bone sparing effect of curcumin and alendronate in ovariectomized rat. Acta Neurochir (Wien) 154 : 2215-2223, 2012 https://doi.org/10.1007/s00701-012-1516-9
  4. Fleisch H : Bisphosphonates : mechanisms of action. Endocr Rev 19 : 80-100, 1998 https://doi.org/10.1210/edrv.19.1.0325
  5. Folwarczna J, Zych M, Trzeciak HI : Effects of curcumin on the skeletal system in rats. Pharmacol Rep 62 : 900-909, 2010 https://doi.org/10.1016/S1734-1140(10)70350-9
  6. French DL, Muir JM, Webber CE : The ovariectomized, mature rat model of postmenopausal osteoporosis : an assessment of the bone sparing effects of curcumin. Phytomedicine 15 : 1069-1078, 2008 https://doi.org/10.1016/j.phymed.2008.06.007
  7. Kashii M, Hashimoto J, Nakano T, Umakoshi Y, Yoshikawa H : Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats. J Bone Miner Metab 26 : 24-33, 2008 https://doi.org/10.1007/s00774-007-0782-8
  8. Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY : Severely suppressed bone turnover : a potential complication of alendronate therapy. J Clin Endocrinol Metab 90 : 1294-1301, 2005 https://doi.org/10.1210/jc.2004-0952
  9. Oh S, Kyung TW, Choi HS : Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells. Mol Cells 26 : 486-489, 2008
  10. Ozaki K, Kawata Y, Amano S, Hanazawa S : Stimulatory effect of curcumin on osteoclast apoptosis. Biochemical Pharmacol 59 : 1577-1581, 2000 https://doi.org/10.1016/S0006-2952(00)00277-X
  11. Palumbo C, Ferretti M, Bertoni L, Cavani F, Resca E, Casolari B, et al. : Influence of ferutinin on bone metabolism in ovariectomized rats. I : role in preventing osteoporosis. J Bone Miner Metab 27 : 538-545, 2009 https://doi.org/10.1007/s00774-009-0070-x
  12. Park SB, Lee YJ, Chung CK : Bone mineral density changes after ovariectomy in rats as an osteopenic model : stepwise description of double dorso-lateral approach. J Korean Neurosurg Soc 48 : 309-312, 2010 https://doi.org/10.3340/jkns.2010.48.4.309
  13. Park SK, Oh S, Shin HK, Kim SH, Ham J, Song JS, et al. : Synthesis of substituted triazolyl curcumin mimics that inhibit RANKL-induced osteoclastogenesis. Bioorg Med Chem Lett 21 : 3573-3577, 2011 https://doi.org/10.1016/j.bmcl.2011.04.106
  14. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL : Osteonecrosis of the jaws associated with the use of bisphosphonates : a review of 63 cases. J Oral Maxillofac Surg 62 : 527-534, 2004 https://doi.org/10.1016/j.joms.2004.02.004
  15. Schneider JP : Should bisphosphonates be continued indefinitely? An unusual fracture in a healthy woman on long-term alendronate. Geriatrics 61 : 31-33, 2006
  16. Sheng ZF, Dai RC, Wang P, Yao XF, Feng XQ, Fang LN, et al. : [Nanomechanical properties of vertebral trabeculae in ovariectomized rats]. Zhonghua Yi Xue Za Zhi 86 : 515-519, 2006
  17. Shin YH, Cho DC, Yu SH, Kim KT, Cho HJ, Sung JK : Histomorphometric analysis of the spine and femur in ovariectomized rats using micro-computed tomographic scan. J Korean Neurosurg Soc 52 : 1-6, 2012 https://doi.org/10.3340/jkns.2012.52.1.1
  18. Shiraishi A, Miyabe S, Nakano T, Umakoshi Y, Ito M, Mihara M : The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis. BMC Musculoskelet Disord 10 : 66, 2009 https://doi.org/10.1186/1471-2474-10-66
  19. Shishodia S, Sethi G, Aggarwal BB : Curcumin : getting back to the roots. Ann N Y Acad Sci 1056 : 206-217, 2005 https://doi.org/10.1196/annals.1352.010
  20. Szulc P, Delmas PD : Biochemical markers of bone turnover : potential use in the investigation and management of postmenopausal osteoporosis. Osteoporos Int 19 : 1683-1704, 2008 https://doi.org/10.1007/s00198-008-0660-9
  21. Watts NB, Diab DL : Long-term use of bisphosphonates in osteoporosis. J Cin Endocrinol Metab 95 : 1555-1565, 2010 https://doi.org/10.1210/jc.2009-1947
  22. Yang KY, Lin LC, Tseng TY, Wang SC, Tsai TH : Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 853 : 183-189, 2007 https://doi.org/10.1016/j.jchromb.2007.03.010
  23. Yang MW, Wang TH, Yan PP, Chu LW, Yu J, Gao ZD, et al. : Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice. Phytomedicine 18 : 205-213, 2011 https://doi.org/10.1016/j.phymed.2010.05.011

피인용 문헌

  1. Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway vol.37, pp.2, 2013, https://doi.org/10.3892/ijmm.2015.2432
  2. Curcumin alleviates glucocorticoid‐induced osteoporosis by protecting osteoblasts from apoptosis in vivo and in vitro vol.43, pp.2, 2016, https://doi.org/10.1111/1440-1681.12513
  3. A STUDY ON THE EVALUATION OF THE PLGA-CURCUMIN TREATED RAT MODELS FOR OSTEOPOROSIS IMPROVEMENT USING FINITE ELEMENT ANALYSIS vol.17, pp.3, 2017, https://doi.org/10.1142/s0219519417500506
  4. The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats vol.14, pp.2, 2013, https://doi.org/10.14245/kjs.2017.14.2.35
  5. Synthesis and characterization of novel bio-material: Nano composites of hydroxyapatite and curcumin vol.15, pp.1, 2018, https://doi.org/10.1111/ijac.12754
  6. Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis vol.62, pp.4, 2013, https://doi.org/10.20945/2359-3997000000060
  7. Comparison between curcumin and all-trans retinoic acid in the osteogenic differentiation of mouse bone marrow mesenchymal stem cells vol.17, pp.5, 2013, https://doi.org/10.3892/etm.2019.7414
  8. The Effect of Curcumin on the Differentiation of Mesenchymal Stem Cells into Mesodermal Lineage vol.24, pp.22, 2013, https://doi.org/10.3390/molecules24224029
  9. Curcumin Protects Osteoblasts From Oxidative Stress-Induced Dysfunction via GSK3β-Nrf2 Signaling Pathway vol.8, pp.None, 2013, https://doi.org/10.3389/fbioe.2020.00625
  10. Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin vol.2021, pp.None, 2013, https://doi.org/10.1155/2021/9980137
  11. The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA‐21, miRNA‐422a, and miRNA‐503 gene in postmenopausal women with low bone ma vol.35, pp.11, 2021, https://doi.org/10.1002/ptr.7259
  12. Co-encapsulation of combinatorial flavonoids in biodegradable polymeric nanoparticles for improved anti-osteoporotic activity in ovariectomized rats vol.24, pp.None, 2013, https://doi.org/10.1016/j.eti.2021.102079