DOI QR코드

DOI QR Code

Osteoimmunology: A Brief Introduction

  • Greenblatt, Matthew B. (Department of Pathology, Brigham and Women's Hospital) ;
  • Shim, Jae-Hyuck (Department of Pathology and Laboratory Medicine, Weill Cornell Medical College)
  • 투고 : 2013.06.21
  • 심사 : 2013.07.08
  • 발행 : 2013.08.30

초록

Recent investigations have demonstrated extensive reciprocal interactions between the immune and skeletal systems, resulting in the establishment of osteoimmunology as a cross-disciplinary field. Here we highlight core concepts and recent advances in this emerging area of study.

키워드

참고문헌

  1. Ali, T., D. Lam, M. S. Bronze, and M. B. Humphrey. 2009. Osteoporosis in inflammatory bowel disease. Am. J. Med. 122: 599-604. https://doi.org/10.1016/j.amjmed.2009.01.022
  2. Papadaki, M. E., S. A. Lietman, M. A. Levine, B. R. Olsen, L. B. Kaban, and E. J. Reichenberger. 2012. Cherubism: best clinical practice. Orphanet. J. Rare. Dis. 7 Suppl 1: S6. https://doi.org/10.1186/1750-1172-7-S1-S6
  3. Karmakar, S., J. Kay, and E. M. Gravallese. 2010. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum. Dis. Clin. North. Am. 36: 385-404. https://doi.org/10.1016/j.rdc.2010.03.003
  4. Seriolo, B., S. Paolino, A. Sulli, V. Ferretti, and M. Cutolo. 2006. Bone metabolism changes during anti-TNF-alpha therapy in patients with active rheumatoid arthritis. Ann. N. Y. Acad. Sci. 1069: 420-427. https://doi.org/10.1196/annals.1351.040
  5. Kotake, S., N. Udagawa, N. Takahashi, K. Matsuzaki, K. Itoh, S. Ishiyama, S. Saito, K. Inoue, N. Kamatani, M. T. Gillespie, T. J. Martin, and T. Suda. 1999. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103: 1345-1352. https://doi.org/10.1172/JCI5703
  6. Sato, K., A. Suematsu, K. Okamoto, A. Yamaguchi, Y. Morishita, Y. Kadono, S. Tanaka, T. Kodama, S. Akira, Y. Iwakura, D. J. Cua, and H. Takayanagi. 2006. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203: 2673- 2682. https://doi.org/10.1084/jem.20061775
  7. Takayanagi, H., K. Ogasawara, S. Hida, T. Chiba, S. Murata, K. Sato, A. Takaoka, T. Yokochi, H. Oda, K. Tanaka, K. Nakamura, and T. Taniguchi. 2000. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408: 600-605. https://doi.org/10.1038/35046102
  8. Gao, Y., F. Grassi, M. R. Ryan, M. Terauchi, K. Page, X. Yang, M. N. Weitzmann, and R. Pacifici. 2007. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen- driven T cell activation. J. Clin. Invest. 117: 122-132. https://doi.org/10.1172/JCI30074
  9. Liu, Y., L. Wang, T. Kikuiri, K. Akiyama, C. Chen, X. Xu, R. Yang, W. Chen, S. Wang, and S. Shi. 2011. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γand TNF-$\alpha$. Nat. Med. 17: 1594- 1601. https://doi.org/10.1038/nm.2542
  10. Gao, Y., X. Wu, M. Terauchi, J. Y. Li, F. Grassi, S. Galley, X. Yang, M. N. Weitzmann, and R. Pacifici. 2008. T cells potentiate PTH-induced cortical bone loss through CD40L signaling. Cell. Metab. 8: 132-145. https://doi.org/10.1016/j.cmet.2008.07.001
  11. Sato, N., N. Takahashi, K. Suda, M. Nakamura, M. Yamaki, T. Ninomiya, Y. Kobayashi, H. Takada, K. Shibata, M. Yamamoto, K. Takeda, S. Akira, T. Noguchi, and N. Udagawa. 2004. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha. J. Exp. Med. 200: 601-611. https://doi.org/10.1084/jem.20040689
  12. Sjogren, K., C. Engdahl, P. Henning, U. H. Lerner, V. Tremaroli, M. K. Lagerquist, F. Backhed, and C. Ohlsson. 2012. The gut microbiota regulates bone mass in mice. J. Bone Miner. Res. 27: 1357-1367. https://doi.org/10.1002/jbmr.1588
  13. Terauchi, M., J. Y. Li, B. Bedi, K. H. Baek, H. Tawfeek, S. Galley, L. Gilbert, M. S. Nanes, M. Zayzafoon, R. Guldberg, D. L. Lamar, M. A. Singer, T. F. Lane, H. M. Kronenberg, M. N. Weitzmann, and R. Pacifici. 2009 . T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell. Metab. 10: 229-240. https://doi.org/10.1016/j.cmet.2009.07.010
  14. Kim, Y. G., C. K. Lee, S. S. Nah, S. H. Mun, B. Yoo, and H. B. Moon. 2007. Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 357: 1046-1052. https://doi.org/10.1016/j.bbrc.2007.04.042
  15. Axmann, R., S. Herman, M. Zaiss, S. Franz, K. Polzer, J. Zwerina, M. Herrmann, J. Smolen, and G. Schett. 2008. CTLA-4 directly inhibits osteoclast formation. Ann. Rheum. Dis. 67: 1603-1609. https://doi.org/10.1136/ard.2007.080713
  16. Zaiss, M. M., B. Frey, A. Hess, J. Zwerina, J. Luther, F. Nimmerjahn, K. Engelke, G. Kollias, T. Hunig, G. Schett, and J. P. David. 2010. Regulatory T cells protect from local and systemic bone destruction in arthritis. J. Immunol. 184: 7238-7246. https://doi.org/10.4049/jimmunol.0903841
  17. Zaiss, M. M., K. Sarter, A. Hess, K. Engelke, C. Böhm, F. Nimmerjahn, R. Voll, G. Schett, and J. P David. 2010. Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation. Arthritis. Rheum. 62: 2328-2338. https://doi.org/10.1002/art.27535
  18. Calvi, L. M, G. B. Adams, K. W. Weibrecht, J. M. Weber, D. P. Olson, M. C. Knight, R. P. Martin, E. Schipani, P. Divieti, F. R. Bringhurst, L. A. Milner, H. M. Kronenberg, and D. T. Scadden. 2003. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425: 841-846. https://doi.org/10.1038/nature02040
  19. Arai, F., A. Hirao, M. Ohmura, H. Sato, S. Matsuoka, K. Takubo, K. Ito, G. Y. Koh, and T. Suda. 2004. Tie2/angiopoietin- 1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 118: 149-161. https://doi.org/10.1016/j.cell.2004.07.004
  20. Tsay, J., Z. Yang, F. P. Ross, S. Cunningham-Rundles, H. Lin, R. Coleman, P. Mayer-Kuckuk, S. B. Doty, R. W. Grady, P. J. Giardina, A. L. Boskey, and M. G. Vogiatzi. 2010. Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 116: 2582-2589. https://doi.org/10.1182/blood-2009-12-260083
  21. Grainger, R. G. and J. W. Laws. 1957. Paget's disease; active or quiescent? Br. J. Radiol. 30: 120-124. https://doi.org/10.1259/0007-1285-30-351-120

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