IMMUNE NETWORK

  • 제13권3호
  • /
  • Pages.102-106
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  • 2013
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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DOI QR코드

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Extravasating Neutrophil-derived Microparticles Preserve Vascular Barrier Function in Inflamed Tissue

  • Lim, Kihong (Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester) ;
  • Sumagin, Ronen (Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine) ;
  • Hyun, Young-Min (Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester)
  • 투고 : 2013.05.14
  • 심사 : 2013.06.03
  • 발행 : 2013.06.30
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초록

Emerging evidence suggests that gap formation and opening of the endothelial junctions during leukocyte extravasation is actively controlled to maintain the integrity of the vascular barrier. While the role for endothelial cells to this process has been well defined, it is not clear whether leukocytes are also actively contributing to endothelial barrier function. We have recently showed that extravasating leukocytes deposit microparticles on the subendothelium during the late stages of extravasation, which is LFA-1 dependent. Using multiphotonintravital microscopy (MP-IVM) of mouse cremaster muscle vessels in the current work, we show that microparticle formation and deposition maintains the integrity of the microvascular barrier during leukocyte extravasation. Inhibition of neutrophil-derived microparticle formation resulted in dramatically increased vascular leakage. These findings suggest that deposition of microparticles during neutrophil extravasation is essential for maintaining endothelial barrier function and may result in temporal difference between neutrophil extravasation and an increase in vascular leakage.

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참고문헌

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