IMMUNE NETWORK

  • 제13권2호
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  • Pages.70-74
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  • 2013
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-${\alpha}/{\beta}$ at the Initial Stage of Influenza A Virus (H3N2) Infection

  • Kim, Yejin (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Kim, Hyemin (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Bae, Seyeon (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Choi, Jiwon (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Lim, Sun Young (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Lee, Naeun (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Kong, Joo Myung (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Hwang, Young-Il (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Kang, Jae Seung (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Lee, Wang Jae (Laboratory of Anti-oxidant Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine)
  • 투고 : 2013.03.05
  • 심사 : 2013.03.22
  • 발행 : 2013.04.30
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초록

L-ascorbic acid (vitamin C) is one of the well-known antiviral agents, especially to influenza virus. Since the in vivo antiviral effect is still controversial, we investigated whether vitamin C could regulate influenza virus infection in vivo by using Gulo (-/-) mice, which cannot synthesize vitamin C like humans. First, we found that vitamin C-insufficient Gulo (-/-) mice expired within 1 week after intranasal inoculation of influenza virus (H3N2/Hongkong). Viral titers in the lung of vitamin C-insufficient Gulo (-/-) mice were definitely increased but production of anti-viral cytokine, interferon (IFN)-${\alpha}/{\beta}$, was decreased. On the contrary, the infiltration of inflammatory cells into the lung and production of pro-inflammatory cytokines, tumor necrosis factor (TNF)-${\alpha}$ and interleukin (IL)-${\alpha}/{\beta}$, were increased in the lung. Taken together, vitamin C shows in vivo antiviral immune responses at the early time of infection, especially against influenza virus, through increased production of IFN-${\alpha}/{\beta}$.

키워드

참고문헌

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