YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Structure-Activity Relationship of Chroman-2-carboxylic Acid N-Arylalkylamide Derivatives

크로만-2-카르복실산 N-아릴알킬아마이드 유도체의 구조-활성관계

  • Received : 2013.11.05
  • Accepted : 2013.11.26
  • Published : 2013.12.31
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Abstract

In our previous studies, 6-hydroxy-7-methoxychroman-2-carboxylic acid N-phenylamide (KL-1156) was identified as a good inhibitor of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activation. In continuation of our study, we describe the structure-activity relationship of chroman derivatives containing N-arylalkyl groups and their NF-${\kappa}B$ inhibitory activities. In addition, inhibitory effects of cell proliferation are evaluated against human cancer cell lines (NCI-H23 and PC-3). The most active compounds 3i and 3j contained diphenylethyl and diphenylpropyl side chain on amide nitrogen.

Keywords

References

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