Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

Early postictal electroencephalography and correlation with clinical findings in children with febrile seizures

  • Jeong, Kyung A (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Han, Myung Hee (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Lee, Eun Hye (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Chung, Sajun (Department of Pediatrics, Kyung Hee University School of Medicine)
  • 투고 : 2013.05.29
  • 심사 : 2013.09.07
  • 발행 : 2013.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Electroencephalography (EEG) is frequently ordered for patients with febrile seizures despite its unclear diagnostic value. We evaluated the prevalence of abnormal EEGs, the association between clinical findings and abnormal EEGs, and the predictive value of EEG for the recurrence of febrile seizures Methods: Data were collected on 230 children who were treated for febrile seizures at Kyung Hee University Medical Center from 2005 to 2009. EEGs were recorded after 1-2 days of hospitalization when children became afebrile. EEG patterns were categorized as normal, epileptiform, or nonspecific relative to abnormalities. The patients' medical records were reviewed, and telephone interviews with the families of the children were conducted to inquire about seizure recurrence. The relationships between clinical variables, including seizure recurrence, and EEG abnormalities were evaluated. Results: Of the 131 children included, 103 had simple and 28 had complex febrile seizures. EEG abnormalities were found in 41 children (31%). EEG abnormalities were more common in children with complex than simple febrile seizures (43% vs. 28%), but the difference was not statistically significant. Logistical regression analysis showed that having multiple seizures in a 24-hour period was significantly predictive of abnormal EEG (odds ratio, 2.98; 95% confidence interval, 1.0 to 88; P =0.048). The frequency of recurrence did not differ significantly in the normal (31%) and abnormal (23%) EEG groups. Conclusion: Multiple seizures within 24 hours were predictive of abnormal EEG in children with febrile seizures. Abnormal EEG was not predictive of febrile seizure recurrence.

키워드

참고문헌

  1. Hauser WA, Kurland LT. The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967. Epilepsia 1975;16:1-66. https://doi.org/10.1111/j.1528-1157.1975.tb04721.x
  2. Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976;295:1029-33. https://doi.org/10.1056/NEJM197611042951901
  3. Subcommittee on Febrile Seizures; American Academy of Pediatrics. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics 2011;127:389-94. https://doi.org/10.1542/peds.2010-3318
  4. Koyama A, Matsui T, Sugisawa T. Febrile convulsions in northern Japan: a quantitative and qualitative analysis of EEG and clinical findings. Acta Neurol Scand 1991;83:411-7. https://doi.org/10.1111/j.1600-0404.1991.tb03974.x
  5. Stores G. When does an EEG contribute to the management of febrile seizures? Arch Dis Child 1991;66:554-7. https://doi.org/10.1136/adc.66.4.554
  6. Frantzen E, Lennox-Buchthal M, Nygaard A. Longitudinal EEG and clinical study of children with febrile convulsions. Electroencephalogr Clin Neurophysiol 1968;24:197-212. https://doi.org/10.1016/0013-4694(68)90001-1
  7. Yamatogi Y, Ohtahara S. EEG in febrile convulsions. Am J EEG Technol 1990;30:267-80.
  8. Consensus statement. Febrile seizures: long-term management of children with fever-associated seizures. Pediatrics 1980;66:1009-12.
  9. Joshi C, Wawrykow T, Patrick J, Prasad A. Do clinical variables predict an abnormal EEG in patients with complex febrile seizures? Seizure 2005;14:429-34. https://doi.org/10.1016/j.seizure.2005.07.006
  10. Thorn I. The significance of electroencephalography in febrile convulsions. In: Akimoto H, Kazamatsuri H, Seino M, Ward A, editors. Advances in epileptology: 13th Epilepsy International Symposium. New York: Raven Press, 1982:93-5.
  11. Yamatogi Y, Othahara S. Electroencephalographic aspects of febrile seizures. Jpn J Clin EEG 1983;25:401-8.
  12. Rantala H, Uhari M, Tuokko H. Viral infections and recurrences of febrile convulsions. J Pediatr 1990;116:195-9. https://doi.org/10.1016/S0022-3476(05)82874-4
  13. Wo SB, Lee JH, Lee YJ, Sung TJ, Lee KH, Kim SK. Risk for developing epilepsy and epileptiform discharges on EEG in patients with febrile seizures. Brain Dev 2013;35:307-11. https://doi.org/10.1016/j.braindev.2012.07.014
  14. Lennox-Buchthal MA. Febrile convulsions: a reappraisal. Electroencephalogr Clin Neurophysiol 1973;32:Suppl:1-138.
  15. Maytal J, Steele R, Eviatar L, Novak G. The value of early postictal EEG in children with complex febrile seizures. Epilepsia 2000; 41:219-21. https://doi.org/10.1111/j.1528-1157.2000.tb00143.x
  16. Sofijanov N, Emoto S, Kuturec M, Dukovski M, Duma F, Ellenberg JH, et al. Febrile seizures: clinical characteristics and initial EEG. Epilepsia 1992;33:52-7. https://doi.org/10.1111/j.1528-1157.1992.tb02282.x
  17. Yücel O, Aka S, Yazicioglu L, Ceran O. Role of early EEG and neuroimaging in determination of prognosis in children with complex febrile seizure. Pediatr Int 2004;46:463-7. https://doi.org/10.1111/j.1328-8067.2003.01799.x
  18. Berg AT, Shinnar S, Darefsky AS, Holford TR, Shapiro ED, Salomon ME, et al. Predictors of recurrent febrile seizures: a prospective cohort study. Arch Pediatr Adolesc Med 1997;151:371-8. https://doi.org/10.1001/archpedi.1997.02170410045006
  19. Pavlidou E, Tzitiridou M, Kontopoulos E, Panteliadis CP. Which factors determine febrile seizure recurrence? A prospective study. Brain Dev 2008;30:7-13. https://doi.org/10.1016/j.braindev.2007.05.001
  20. Kuturec M, Emoto SE, Sofijanov N, Dukovski M, Duma F, Ellenberg JH, et al. Febrile seizures: is the EEG a useful predictor of recurrences? Clin Pediatr (Phila) 1997;36:31-6. https://doi.org/10.1177/000992289703600105
  21. Kim H, Byun SH, Kim JS, Lim BC, Chae JH, Choi J, et al. Clinical and EEG risk factors for subsequent epilepsy in patients with complex febrile seizures. Epilepsy Res 2013;105:158-63. https://doi.org/10.1016/j.eplepsyres.2013.02.006
  22. Kanemura H, Mizorogi S, Aoyagi K, Sugita K, Aihara M. EEG characteristics predict subsequent epilepsy in children with febrile seizure. Brain Dev 2012;34:302-7. https://doi.org/10.1016/j.braindev.2011.07.007

피인용 문헌

  1. Clinical characteristics and electroencephalogram analysis of levetiracetam in the treatment of children with febrile seizure recurrence vol.14, pp.3, 2017, https://doi.org/10.3892/etm.2017.4738