생명과학회지 (Journal of Life Science)

  • 제23권1호
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  • Pages.143-156
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  • 2013
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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대장암에 대한 butyrate의 효과

Effects of Butyrate on Colorectal Cancer

  • 진지영 (신라대학교 생물과학과) ;
  • 조광근 (경남과학기술대학교 동물소재공학과) ;
  • 최인순 (신라대학교 생물과학과)
  • Jin, Ji Young (Department of Biological Science, Silla University) ;
  • Cho, Kwang Keun (Department of Animal Resources Technology, Gyeongnam National University of Science and Technology) ;
  • Choi, In Soon (Department of Biological Science, Silla University)
  • 투고 : 2013.01.16
  • 심사 : 2013.01.25
  • 발행 : 2013.01.30
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초록

현재 우리나라는 높은 암 발생률과 사망률로 인해 암에 대한 관심과 심리적 불안감이 높아지고 있고, 따라서 많은 연구가 진행되고 있는 실정이다. 그럼에도 불구하고 암 발생률 빈도는 현저하게 증가하고 있는 추세이며, 그 중에서도 발병률이 높은 대장암은 발견 또한 늦어 사망률이 높다. 따라서 대장암의 예방이 무엇보다도 시급하다. 원인은 아주 다양하면서도 정확하게 규명되진 않았지만, 가장 크게 식생활의 서구화로 인한 결과로 여겨진다. 육류 위주의 서구식 식이습관 개선을 위해 식이섬유를 풍부하게 섭취하게 되면 항암제 역할을 하는 단쇄지방산인 butyrate가 위장관 내에서 장내 미생물에 의해 발생된다. 암의 치료에 있어서 항암제들은 종양세포의 apoptosis를 유도한다는 것이 알려졌고, 종양세포의 apoptosis 기전과 암의 치유기전 사이에는 서로 깊은 연관이 있음이 확인되었다. 따라서 butyrate가 직접적으로 대장암 세포의 apoptosis를 일으킴으로써 대장암을 억제하는 효과를 연구결과들을 통해서 확인하였고, 이는 대장암의 예방 및 치료에 직접적으로 영향을 미칠 것을 기대한다.

Due to the high incidence of cancer and cancer-related mortality in Korea, there is increased concern and psychological anxiety about this disease, leading to increasing numbers of cancer studies. Despite these, the trend of the cancer incidence rate has shown a significant increase. The detection of colorectal cancer, which has a high incidence rate, often tends to be delayed, causing a high mortality rate. Therefore, the prevention of colorectal cancer has become an important emergent issue. The cause of this cancer has not been confirmed. However, it may be attributable to westernized dietary patterns, which include consuming a high quantity of red meat. Consumption of dietary fiber promotes the production of butyrate short-chain fatty acids by enteric bacteria. In the treatment of cancer, anticancer medications have been shown to lead to the apoptosis of tumor cells, and a strong relationship between apoptosis mechanisms of tumor cells and cancer treatment has been confirmed. The results of many studies have confirmed that butyrate can directly promote the apoptosis of colorectal cancer cells. Therefore, increased consumption of dietary fiber, which promotes the production of butyrate shortchain fatty acids, can be expected to have an effect on the prevention and treatment of colorectal cancer.

키워드

참고문헌

  1. Adams, J. M. and Cory, S. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322-1326. https://doi.org/10.1126/science.281.5381.1322
  2. Archer, S. Y., Meng, S., Shei, A. and Hodin, R. A. 1998. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci 95, 6791-6796. https://doi.org/10.1073/pnas.95.12.6791
  3. Arthur, J. C., Perez-Chanona, E., Muhlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T. J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., Rhodes, J. M., Stintzi, A., Simpson, K. W., Hansen, J. J., Keku, T. O., Fodor, A. A. and Jobin, C. 2012. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338, 120-123. https://doi.org/10.1126/science.1224820
  4. Bach Knudsen, K. E. 2001. The nutritional significance of "dietary fibre" analysis. Ani Feed Sci Tech 90, 3-20. https://doi.org/10.1016/S0377-8401(01)00193-6
  5. Belmokhtar, C. A., Hillion, J., Dudognon, C., Fiorentino, S., Flexor, M., Lanotte, M. and Segal-Bendirdjian, E. 2003. Apoptosome-independent pathway for apoptosis. Biochemical analysis of AP AF-l defects and biological outcomes. J Biol Chem 278, 29571-29580. https://doi.org/10.1074/jbc.M302924200
  6. Bergman, E. N. 1990. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 70, 567-590.
  7. Berni Canani, R., Di Costanzo, M. and Leone, L. 2012. The epigenetic effects of butyrate: potential therapeutic implications for clinical practice. Clin Epigenetics 4, 4. https://doi.org/10.1186/1868-7083-4-4
  8. Bora, C. 2010. Colon Function. http://www.buzzle.com/
  9. Canani, R. B., Costanzo, M. D., Leone, L., Pedata, M., Meli, R. and Calignano, A. 2011. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol 17, 1519-1528. https://doi.org/10.3748/wjg.v17.i12.1519
  10. Chopin, V., Toillon, R. A., Jouy, N. and Bourhis. X. L. 2002. Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. Br J Pharmacal 135, 79-86. https://doi.org/10.1038/sj.bjp.0704456
  11. Chung, J. H. 2012. Ministry of Health and Welfare. http://www.mw.go.kr/
  12. Grunstein, M. 1997. Histone acetylation in chromatin structure and transcription. Nature 389, 349-352. https://doi.org/10.1038/38664
  13. Hamer, H. M., Jonkers, D., Venema, K., Vanhoutvin, S., Troost, F. J. and Brummer, R. J. 2008. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 27, 104-119.
  14. Han, W. K. 1998. Rectal Cancer. Healthy in middle age beyond 14. Samsung Medical Center. http://www.smc.or.kr/
  15. Hassig, C. A., Tong, J. K. and Schreiber, S. L. 1997. Fiber-derived butyrate and the prevention of colon cancer. Chem Biol 4, 783-789. https://doi.org/10.1016/S1074-5521(97)90111-3
  16. Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D. and Korsmeyer, S. J. 1990. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334-346. https://doi.org/10.1038/348334a0
  17. Hong, S. O., Lee, B. S., Yang, W. I., Lee, J. S., Cha, D. H., Cho, Y. S., Kim, J. Y., Park, K. H., Cho, D. J. and Song, C. H. 2000. Bcl-2 and bax expression in normal human endometrium. Kor J Fertil Steril 27, 245-251.
  18. Hsu, Y. T., Wolter, K. G. and Youle, R. J. 1997. Cytosol-to membrane redistribution of Bax and Bcl-XL during apoptosis. Proc Natl Acad Sci USA 94, 3668-3672. https://doi.org/10.1073/pnas.94.8.3668
  19. Hwa, Y. D. and Gwang, J. G. 2005. Funtional Genoproteome Research Center. http://genehunters.co.kr/
  20. Im, B. U. and Jo, Y. W. 2002. Immunomodulatory functions of dietary fiber and study on short chain acid. Bulletin Food Technol 15, 84-91.
  21. Johnstone, R. W. and Licht, J. D. 2003. Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 4, 13-18. https://doi.org/10.1016/S1535-6108(03)00165-X
  22. Kim, J. C. 2005. Genopathogenesis of Colorectal Cancer. J Korean Surg Soc 69, 189-198.
  23. Kim, Y. M. 2006. Physical activity and dietary modification for prevention of colon cancer. J Coa Dev 8, 3-11.
  24. Kim, Y. S. and Milner, J. A. 2007. Dietary modulation of colon cancer risk. J Nutr 137, 2576S-2579S.
  25. Kruh, J. 1982. Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 42, 65-82.
  26. Kumar, V., Sinha, A. K., Makkar, H. P., Boeck, G. and Becker, K. 2012. Dietary roles of non-starch polysachharides in human nutrition: a review. Crit Rev Food Sci Nutr 52, 899-935. https://doi.org/10.1080/10408398.2010.512671
  27. Lavrik, I. N. and Krammer, P. H. 2012. Regulation of CD95/Fas signaling at the DISC. Cell Death Differ 19, 36-41. https://doi.org/10.1038/cdd.2011.155
  28. Lee, D. Y., Chapkin, R. S. and Lupton, J. R. 1993. Dietary fat and fiber modulate colonic cell proliferation in an interactive site-specific manner. Nutr Cancer 20, 107-118. https://doi.org/10.1080/01635589309514277
  29. Lee, J. S., Kim, Y. J., Kim, C. L. and Lee, G. M. 2012. Differential induction of autophagy in caspase-3/7 down-regulating and Bcl-2 overexpressing recombinant CHO cells subjected to sodium butyrate treatment. J Biotechnol 161, 34-41.
  30. MacFarlane, M. and Williams, A. C. 2004. Apoptosis and disease: a life or death decision. EMBO Rep 5, 674-678. https://doi.org/10.1038/sj.embor.7400191
  31. Marks, P. A., Richon, V. M. and Rifkind, R. A. 2000. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 92, 1210-1216. https://doi.org/10.1093/jnci/92.15.1210
  32. Marks, P., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T. and Kelly, W. K. 2001. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 1, 194-202. https://doi.org/10.1038/35106079
  33. Medina, V., Edmonds, B., Young, G. P., James, R., Appleton, S. and Zalewski, P. D. 1997. Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res 57, 3697-3707.
  34. Yoshida, M. 2008 Chemical genetics enables an approach to life phenomena and developments in drug discovery. Riken Res 3, 5568.
  35. National Cancer Information Center. 2010. http://www.cancer.go.kr/
  36. Natoni, F., Diolordi, L., Santoni, C. and Gilardini Montani, M. S. 2005. Sodium butyrate sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic apoptotic pathways. Biochim Biophys Acta 1745, 318-329. https://doi.org/10.1016/j.bbamcr.2005.07.003
  37. Nguyen, K. A., Cao, Y., Chen, J. R., Chen, J. R., Townsend, C. M. and Ko, T. C. 2006. Dietary fiber enhances a tumor suppressor signaling pathway in the gut. Ann Surg 243, 619-625. https://doi.org/10.1097/01.sla.0000216783.85214.c1
  38. Oh, K. J., Singh, P., Lee, K., Foss, K., Lee, S., Park, M., Lee, S., Aluvila, S., Park, M., Singh, P., Kim, R. S., Symersky, J. and Walters, D. E. 2010. Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers. J Biol Chem 285, 28924-28937. https://doi.org/10.1074/jbc.M110.135293
  39. Park, J. E., Lee, S. G., Lim, H. J., Kim J. Y., Chung, J.Y., Kim, Y. J., Lee, C. H., Lee, M. K., Yoo, K. S., Yoo, Y. H. and Kim, J. M. 2009. Evaluation of cell death and the reduction of ERK phosphorylation in non-small cell lung cancer cells after exposure to sodium butyrate. J Life Sci 19, 1314-1320. https://doi.org/10.5352/JLS.2009.19.9.1314
  40. Roy, M. J., Dionne, S., Marx, G., Qureshi, I., Sarma, D., Levy, E. and Seidman, E. G. 2009. In vitro studies on the inhibition of colon cancer by butyrate and carnitine. Nutrition 25, 1193-1201. https://doi.org/10.1016/j.nut.2009.04.008
  41. Rueda, M., Robertson, Y., Acott, A., Rueda, S., Keikhoff, A., Guerrero, W. and Mancino, A. T. 2012. Association of tobacco and alcohol use with earlier development of colorectal pathology: should screening guidelines be modified to include these risk factors? Am J Surg 204, 963-968. https://doi.org/10.1016/j.amjsurg.2012.07.026
  42. Ruemmele, F. M, Dionne, S., Qureshi, I., Sarma, D. S., Levy, E. and Seidman, E. G. 1999. Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP). Cell Death Differ 6, 729-735. https://doi.org/10.1038/sj.cdd.4400545
  43. Ruemmele, F. M., Schwartz, S., Seidman, E. G., Dionne, S., Levy, E. and Lentze, M. J. 2003. Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway. Gut 52, 94-100. https://doi.org/10.1136/gut.52.1.94
  44. Satelli, A. and Rao, U. S. 2011. Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells. Cancer Lett 301, 38-46. https://doi.org/10.1016/j.canlet.2010.10.027
  45. Siegel, R., Naishadham, D. and Jemal, A. 2012. Cancer statistics. CA Cancer J Clin 62, 10-29. https://doi.org/10.3322/caac.20138
  46. Topping, D. L. and Clifton, P. M. 2001. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81, 1031-1064.
  47. Turk, H. F., Kolar, S. S., Fan, Y. Y., Cozby, C. A., Lupton, J. R. and Chapkin, R. S. 2011. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. Int J Cancer 128, 63-71. https://doi.org/10.1002/ijc.25323
  48. Vargas, A. J. and Thompson, P. A. 2012. Diet and nutrient factors in colorectal cancer risk. Nutr Clin Pract 27, 613-623. https://doi.org/10.1177/0884533612454885
  49. Yang, E. J. and Kim, W. Y. 1993. A study on dietary factors related to the incidence of stomach cancer and colon cancer in Korea. Korean J Nutrition 26, 603-614.
  50. Zhang, Y., Zhou, L., Bao, Y. L., Wu, Y., Yu, C. L., Huang, Y. X., Sun, Y., Zheng, L. H. and Li, Y. X. 2010. Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. Chem Biol Interact 185, 174-181. https://doi.org/10.1016/j.cbi.2010.03.035

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