Journal of Korean Dental Science

Korean Academy of Dental Science (대한치의학회)
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Effectiveness of Autogenous Tooth Bone Graft Combined with Growth Factor: Prospective Cohort Study

  • Ahn, Kyo-Jin (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital) ;
  • Kim, Young-Kyun (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital) ;
  • Yun, Pil-Young (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital) ;
  • Lee, Bu-Kyu (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Asan Medical Center)
  • Received : 2013.11.18
  • Accepted : 2013.12.19
  • Published : 2013.12.30
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Abstract

Purpose: Autogenous tooth bone graft is proven to be efficient. We evaluated the bone healing effect and clinical capabilities of autogenous tooth bone materials as a scaffold when growth factor is used together with this material. Materials and Methods: Subjects were those who needed implant placement and bone graft because of missing tooth or alveolar bone defect and who kept their autogenous tooth or needed extraction of other tooth. Group I included autogenous tooth bone graft with growth factor, whereas Group II had only autogenous tooth bone graft. We investigated the bone healing state through computed tomography taken just before surgery and 3 to 4 months after surgery to evaluate the effectiveness of bone graft. Group I had 9 patients, whereas Group II had 5 patients. We compared the pre- and post-operative increase of the Hounsfield unit and bone height by analyzing the computed tomography images. Result: Sinus bone grafts numbered 8 cases, and vertical ridge augmentation was performed together with 3 cases of these. Vertical ridge augmentation was performed in 2 cases, and horizontal ridge augmentation in 1 case alone. Socket graft was done in 3 cases. The post-operative mean value of the Hounsfield unit was 960 in Group I and 836.7 in Group II, but the increase was almost similar, i.e., 636.9 in Group I and 634.7 in Group II on the average. Increase of bone height was 7.6 mm in Group I and 11.1 mm in Group II on the average. This difference was attributable to the fact that most of the cases were sinus bone graft in Group II. Conclusion: In this study, we suggest the possibility of autogenous tooth bone graft materials as a scaffold besides their bone healing ability.

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References

  1. Kim YK . Regenerative medicine for the reconstruction of hard tissue defects in oral and maxillofacial surgery. J Korean Assoc Oral Maxillofac Surg. 2012; 38: 69-70. https://doi.org/10.5125/jkaoms.2012.38.2.69
  2. Park BW, Byun JH, Hah YS, Kim DR, Chung IK, Kim JR, Kim UK, Park BS, Kim GC. Expression of vascular endothelial growth factor receptors in tumor and stromal cells of tongue squamous cell carcinoma. J Korean Assoc Oral Maxillofac Surg. 2007; 33: 11-9.
  3. Lee JH, Kim CS, Choi KH, Jung UW, Yun JH, Choi SH, Cho KS. The induction of bone formation in rat calvarial defects and subcutaneous tissues by recombinant human BMP-2, produced in Escherichia coli. Biomaterials. 2010; 31: 3512-9. https://doi.org/10.1016/j.biomaterials.2010.01.075
  4. Byun JH, Kang EJ, Maeng GH, Rho GJ, Kang DH, Lee JS, Park BW. Maxillary sinus floor elevation using autogenous skin-derived mesenchymal stem cells in miniature pigs. J Korean Assoc Oral Maxillofac Surg. 2010; 36: 87-93. https://doi.org/10.5125/jkaoms.2010.36.2.87
  5. Kim YK, Kim SG, Byeon JH, Lee HJ, Um IU, Lim SC, Kim SY. Development of a novel bone grafting material using autogenous teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109: 496-503. https://doi.org/10.1016/j.tripleo.2009.10.017
  6. Kim YK. Bone graft material using teeth. J Korean Assoc Oral Maxillofac Surg. 2012; 38: 134-8. https://doi.org/10.5125/jkaoms.2012.38.3.134
  7. Kim YK, Lee J, Um IW, Kim KW, Murata M, Akazawa T, Mitsugi M. Tooth-derived bone graft material. J Korean Assoc Oral Maxillofac Surg. 2013; 39: 103-11. https://doi.org/10.5125/jkaoms.2013.39.3.103
  8. Kim YK, Kim SG, Yun PY, Yeo IS, Jin SC, Oh JS, Kim HJ, Yu SK, Lee SY, Kim JS, Um IW, Jeong MA, Kim GW. Autogenous teeth used for bone grafting: a comparison with traditional grafting materials. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012. [Epub ahead of print]
  9. Guizzardi S, Galli C, Govoni P, Boratto R, Cattarini G, Martini D, Belletti S, Scandroglio R. Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: a new proposal for bone tissue repair. Life Sci. 2003; 73: 1973-83. https://doi.org/10.1016/S0024-3205(03)00547-2
  10. Sini P, Denti A, Cattarini G, Daglio M, Tira ME, Balduini C. Effect of polydeoxyribonucleotides on human fibroblasts in primary culture. Cell Biochem Funct. 1999; 17: 107-14. https://doi.org/10.1002/(SICI)1099-0844(199906)17:2<107::AID-CBF815>3.0.CO;2-#
  11. Thellung S, Florio T, Maragliano A, Cattarini G, Schettini G. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes. Life Sci. 1999; 64: 1661-74. https://doi.org/10.1016/S0024-3205(99)00104-6
  12. Bitto A, Galeano M, Squadrito F, Minutoli L, Polito F, Dye JF, Clayton EA, Calo M, Venuti FS, Vaccaro M, Altavilla D. Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury. Crit Care Med. 2008; 36: 1594-602. https://doi.org/10.1097/CCM.0b013e318170ab5c
  13. Galeano M, Bitto A, Altavilla D, Minutoli L, Polito F, Calo M, Lo Cascio P, Stagno d'Alcontres F, Squadrito F. Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse. Wound Repair Regen. 2008; 16: 208-17. https://doi.org/10.1111/j.1524-475X.2008.00361.x
  14. Raposio E, Guida C, Coradeghini R, Scanarotti C, Parodi A, Baldelli I, Fiocca R, Santi PL. In vitro polydeoxyribonucleotide effects on human preadipocytes. Cell Prolif. 2008; 41: 739-54. https://doi.org/10.1111/j.1365-2184.2008.00547.x
  15. Kim YK, Lee JK, Kim KW, Um IW, Murata M. Healing mechanism and clinical application of autogenous tooth bone graft material. In: Pignatello R, ed. Advances in biomaterials science and biomedical applications [Internet]. Rijeka, Croatia: InTech; 2013 [cited 2013 Mar 3]. Available from: http://www.intechopen.com/books/references/advances-in-biomaterials-science-andbiomedical-applications/healing-mechanism-andclinical-application-of-autogenous-tooth-bonegraft-material.
  16. Kim YK, Lee HJ, Kim KW, Kim SG, Um IW. Guide bone regeneration using autogenous teeth: case reports. J Korean Assoc Oral Maxillofac Surg. 2011; 37: 142-7. https://doi.org/10.5125/jkaoms.2011.37.2.142
  17. Murata M, Akazawa T, Mitsugi M, Um IW, Kim KW, Kim YK. Human dentin as novel biomaterial for bone regeneration. In: Pignatello R, ed. Biomaterials: physics and chemistry [Internet]. Rijeka, Croatia: InTech; 2011 [cited 2011 Nov 1]. Available from: http://www.intechopen.com/books/biomaterials-physics-and-chemistry/human-dentin-as-novel-biomaterial-for-boneregeneration.
  18. Murata M, Akazawa T, Mitsugi M, Kabir MA, Um IW, Minamida Y, Kim KW, Kim YK, Sun Y, Qin C. Autograft of dentin materials for bone regeneration. In: Pignatello R, ed. Advances in biomaterials science and biomedical applications [Internet]. Rijeka, Croatia: InTech; 2013 [cited 2013 Mar 3]. Available from: http://www.intechopen.com/books/advances-in-biomaterials-scienceand-biomedical-applications/autograft-of-dentinmaterials-for-bone-regeneration.
  19. Kim JY, Kim KW, Um IW, Kim YK, Lee JK. Bone healing capacity of demineralized dentin matrix materials in a mini-pig cranium defect. J Korean Dent Sci. 2012; 5: 21-8. https://doi.org/10.5856/JKDS.2012.5.1.21
  20. Kim YK, Kim SG, Oh JS, Jin SC, Son JS, Kim SY, Lim SY. Analysis of the inorganic component of autogenous tooth bone graft material. J Nanosci Nanotechnol. 2011; 11: 7442-5. https://doi.org/10.1166/jnn.2011.4857

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