Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Homogeneity in Case/Control Numbers and North Indian Caste Criteria in Cervical Cancer/Female Urology Genetic-Studies at a Premier Medical Research Institute in Lucknow, India

  • Pandey, Saumya (Krishna Medical Centre, Sanjay Gandhi Post Graduate Institute of Medical Sciences) ;
  • Chandravati, Chandravati (Krishna Medical Centre, Sanjay Gandhi Post Graduate Institute of Medical Sciences)
  • Published : 2013.10.30
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Abstract

Cervical cancer has emerged as a major public health problem in Lucknow and New York in the $21^{st}$ century. Cancer genetic studies are essential to identify/stratify disease-susceptible individuals in a population-based cohort. Sample size homogeneity and North Indian caste in female urology genetic-studies are significant issues in meaningful interpretation of data. A review of scientific literature using Pubmed database was conducted, including an assessment of cervical cancer genetic studies conducted as part of the author's doctoral dissertation at a premier Lucknow-based medical research Institute. Sample size numbers and caste criteria in the North Indian cohort ($N{\leq}400$ subjects) were evaluated with homogeneity in the sample cohort data set(s). Subgroup caste-stratification of North Indian cohort is equally essential, for instance, Brahmin (e.g. Pandey), Vaishya (e.g. Mittal), Rajput (e.g. Singh) and Kshudra (e.g. Yadav) during the conception and design of genetics-based studies. Sample size homogeneity in histopathologically confirmed case and control numbers and caste-based stratification in a North Indian cohort is essential in single nucleotide polymorphism (SNP) studies in cervical cancer susceptible populations to draw more definitive conclusions.

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References

  1. de Oliveira JG, Silva AE (2012). Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population. World J Gastroenterol, 18, 1235-42. https://doi.org/10.3748/wjg.v18.i11.1235
  2. Gangwar R, Pandey S, Mittal RD (2009). Association of interferon-${\gamma}$ +874A polymorphism with the risk of developing cervical cancer in north-Indian population. BJOG, 116, 1671-7. https://doi.org/10.1111/j.1471-0528.2009.02307.x
  3. Lee CH, Dershaw DD, Kopans D, et al (2010). Breast cancer screening with Imaging: Recommendations from the Society of Breast Imaging and the ACR on the use of Mammography, Breast MRI, Breast Ultrasound, and other technologies for the detection of clinically occult breast cancer. J Am Coll Radiol, 27, 18-27.
  4. Leong SPL, Shen ZZ, Liu TJ, et al (2010). Is breast cancer the same disease in Asian and Western Countries? World J Surg, 34, 2308-24. https://doi.org/10.1007/s00268-010-0683-1
  5. Pandey S, Chandravati (2012). Autophagy in Cervical Cancer: an emerging therapeutic target. Asian Pac Cancer Prev, 13, 4881-5. https://doi.org/10.7314/APJCP.2012.13.10.4867
  6. Pandey S, Mittal RD, Srivastava M, et al (2009). Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility inNorth Indian women. Gynecol Oncol, 114, 501-5. https://doi.org/10.1016/j.ygyno.2009.05.032
  7. Pandey S, Mittal RD, Srivastava M, et al (2010).Cyclooxygenase-2 gene polymorphisms and risk of cervical cancer in a North Indian Population. Int J Gynecol Cancer, 20, 625-30. https://doi.org/10.1111/IGC.0b013e3181c63f79
  8. Pandey S, Mittal RD, Srivastava M, et al (2011). Evaluation of toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility. Mol Biol Rep, 38, 4715-21. https://doi.org/10.1007/s11033-010-0607-z
  9. Pandey S, Chandravati (2013). Robotic prostatectomy in urological surgery: an observership at Weill Medical College of Cornell University, New York. Asian Pac J Cancer Prev, 14, 4945. https://doi.org/10.7314/APJCP.2013.14.8.4945
  10. Shavers VL, Harlan LC, Stevens JL (2003). Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients https://doi.org/10.1002/cncr.11051
  11. Yu JT, Mou SM, Wang LZ, et al (2011). Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer's disease. J Neuroinflammation, 8, 136. https://doi.org/10.1186/1742-2094-8-136