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Genotype Distribution and Behavioral Risk Factor Analysis of Human Papillomavirus Infection in Uyghur Women

  • Sui, Shuang (Postgraduate College of Xinjiang Medical University) ;
  • Jiao, Zhen (Department of Gynecology, People's Hospital of Xinjiang Uyghur Autonomous Region) ;
  • Niyazi, Mayinuer (Department of Gynecology, People's Hospital of Xinjiang Uyghur Autonomous Region) ;
  • Sulaiya, Sulaiya (Department of Gynecology, People's Hospital of Xinjiang Uyghur Autonomous Region) ;
  • Lu, Ping (Department of Gynecology, People's Hospital of Xinjiang Uyghur Autonomous Region) ;
  • Qiao, You-Lin (Department of Cancer Epidemiology, Cancer Institute and hospital, Chinese Academy of Medical Sciences)
  • Published : 2013.10.30

Abstract

We investigated the distribution of HPV genotypes in Uyghur women in Xinjiang region of China, and behavioral factors which could predispose them to HPV infection. In this cross-sectional study, women aged 15-59 years were recruited by cluster sampling method in Yutian region in 2009. Liquid-based cytology samples were analyzed centrally for HPV genotype with a linear array detector. Univariate and multivariate logistic regression analyses were performed to identify behavioral risk factors for HPV infection. A total of 883 Uyghur women were recruited successfully. The prevalence of high-risk HPV and low-risk HPV were 7.25% and 1.58%, respectively; the most common HPVs were HPV16, 51, 31, 39 and 58. We found that age of first sexual intercourse was a strong predictor for HPV infection (odds ratio of 4.01 for ${\leq}15$ years versus ${\geq}25$). Having sexual partners ${\geq}3$ was the second predictor (OR 3.69, 95% CI 2.24-7.16). Cleaning the vagina after sex showed an increased risk of HPV infection (OR 2.72; 95% CI 1.98-5.13); Using the condom showed protective factors for HPV infection (OR 0.36; 95%CI0.12-0.53). HPV16, 51, 31, 39 and 58 were the priority types; the age of first sexual intercourse was identified as a major risk factor for HPV infection. Other notable risks were number of sexual partners and cleaning the vagina after sex. Changing these behavioral risk factors could help to reduce the occurrence of cervical cancer in this population.

Keywords

References

  1. Arbyn M, Castellsague X, de Sanjose S, et al (2011). Worldwide burden of cervical cancer in 2008. Ann Oncol, 22, 2675-86. https://doi.org/10.1093/annonc/mdr015
  2. Arbyn M, Walker A, Meijer CJ (2010). HPV-based cervical-cancer screening in China. Lancet Oncol, 11, 1112-3. https://doi.org/10.1016/S1470-2045(10)70262-X
  3. Bao YP, Li N, Smith JS, Qiao YL (2008). Human papillomavirus type-distribution in the cervix of Chinese women: a meta-analysis. Int J STD AIDS, 19, 106-11. https://doi.org/10.1258/ijsa.2007.007113
  4. Boccalini S, Tiscione E, Bechini A, et al (2012). Sexual behavior, use of contraceptive methods and risk factors for HPV infections of students living in central Italy: implications for vaccination strategies. J Prev Med Hyg, 53, 24-9.
  5. Cokkinides VE, Bandi P, Siegel RL, Jemal A (2012). Cancer-related risk factors and preventive measures in US Hispanics/Latinos. CA Cancer J Clin, 62, 353-63. https://doi.org/10.3322/caac.21155
  6. Confortini M, Carozzi F, Zappa M, et al (2010). Human papillomavirus infection and risk factors in a cohort of Tuscan women aged 18-24: results at recruitment. BMC Infect Dis, 10, 157. https://doi.org/10.1186/1471-2334-10-157
  7. de Sanjose S, Diaz M, Castellsague X, et al (2007). Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis, 7, 453-9. https://doi.org/10.1016/S1473-3099(07)70158-5
  8. De Vuyst H, Ndirangu G, Moodley M, et al (2012). Prevalence of human papillomavirus in women with invasive cervical carcinoma by HIV status in Kenya and South Africa. Int J Cancer, 131, 949-55. https://doi.org/10.1002/ijc.26470
  9. Faust H, Jelen MM, Poljak M, et al (2013). Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types. J Clin Virol, 56, 336-41. https://doi.org/10.1016/j.jcv.2012.12.004
  10. Guan P, Howell-Jones R, Li N, et al (2012). Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer, 131, 2349-59. https://doi.org/10.1002/ijc.27485
  11. Guerry SL, De Rosa CJ, Markowitz LE, et al (2011). Human papillomavirus vaccine initiation among adolescent girls in high-risk communities. Vaccine, 29, 2235-41. https://doi.org/10.1016/j.vaccine.2011.01.052
  12. Guzalinuer A, Chen JX (2007). The spectrum of HPV infection in Xinjiang Uyghur women with cervical cancer. Tumor, 27, 379-82.
  13. Guzhalinuer A, Chen JX, Mick R (2007). HPV spectroscopy study of Xinjiang Uyghur cancer women. Tumor, 2007, 329-82.
  14. Hogewoning CJ, Bleeker MC, van den Brule AJ, et al (2003). Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: a randomized clinical trial. Int J Cancer, 107, 811-6. https://doi.org/10.1002/ijc.11474
  15. Murphy J, Mark H (2012). Cervical cancer screening in the era of human papillomavirus testing and vaccination. J Midwifery Womens Health, 57, 569-76. https://doi.org/10.1111/j.1542-2011.2012.00207.x
  16. Nam K, Kwak J, Kim J, Jeon S (2013). Human papillomavirus type 16 causes larger colposcopic lesions than other HPV types in patients with grade 3 cervical intraepithelial neoplasia. J Low Genit Tract Dis, 17, 1-5.
  17. Pandey S, Mishra M, Chandrawati (2012). Human papillomavirus screening in north Indian women. Asian Pac J Cancer Prev, 13, 2643-6. https://doi.org/10.7314/APJCP.2012.13.6.2643
  18. Peralta-Rodriguez R, Romero-Morelos P, Villegas-Ruiz V, et al (2012). Prevalence of human papillomavirus in the cervical epithelium of Mexican women: meta-analysis. Infect Agent Cancer, 7, 34. https://doi.org/10.1186/1750-9378-7-34
  19. Quek SC, Lim BK, Domingo E, et al (2013). Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in Asia. Int J Gynecol Cancer, 23, 148-56. https://doi.org/10.1097/IGC.0b013e31827670fd
  20. Rana MM, Huhtala H, Apter D, et al (2013). Understanding long-term protection of human papillomavirus vaccination against cervical carcinoma: Cancer registry-based follow-up. Int J Cancer, 132, 2833-8. https://doi.org/10.1002/ijc.27971
  21. Raychaudhuri S, Mandal S (2012). Socio-demographic and behavioural risk factors for cervical cancer and knowledge, attitude and practice in rural and urban areas of North Bengal, India. Asian Pac J Cancer Prev, 13, 1093-6. https://doi.org/10.7314/APJCP.2012.13.4.1093
  22. Sanchez-Lander J, Cortinas P, Loureiro CL, et al (2012). Human papillomavirus in invasive cervical cancer and cervical intraepithelial neoplasia 2 and 3 in Venezuela: a cross-sectional study. Cancer Epidemiol, 36, e284-7. https://doi.org/10.1016/j.canep.2012.04.005
  23. Sharma M, Bruni L, Diaz M, et al (2013). Using HPV prevalence to predict cervical cancer incidence. Int J Cancer, 132, 1895-900. https://doi.org/10.1002/ijc.27835
  24. Siriaunkgul S, Utaipat U, Suwiwat S, et al (2012). Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix. Asian Pac J Cancer Prev, 13, 3281-5. https://doi.org/10.7314/APJCP.2012.13.7.3281
  25. Velicer C, Zhu X, Vuocolo S, Liaw KL, Saah A (2009). Prevalence and incidence of HPV genital infection in women. Sex Transm Dis, 36, 696-703. https://doi.org/10.1097/OLQ.0b013e3181ad25ff
  26. Wang L, Dai SZ, Chu HJ, Cui HF, Xu XY (2013). Integration sites and genotype distributions of human papillomavirus in cervical intraepithelial neoplasia. Asian Pac J Cancer Prev, 14, 3837-41. https://doi.org/10.7314/APJCP.2013.14.6.3837
  27. Zou L, Bao YP, Li N, et al (2011). Life-style and genital human papillomavirus in a cross-sectional survey in Shanxi Province, China. Asian Pac J Cancer Prev, 12, 781-6.

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