Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

  • Rasool, Sabha (Department of Biochemistry, University of Kashmir) ;
  • Kadla, Showkat Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Khan, Tanzeela (Department of Biochemistry, University of Kashmir) ;
  • Qazi, Falak (Department of Biochemistry, University of Kashmir) ;
  • Shah, Nisar Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Basu, Javed (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Khan, Bilal Ahmad (Division of Gastroeneterology, Department of Medicine, Government Medical College Srinagar) ;
  • Ahktar, Qulsum (Department of Biochemistry, University of Kashmir) ;
  • Sameer, Aga Syed (Department of Clinical Biochemistry, Government Medical College) ;
  • Ganai, Bashir Ahmad (Department of Biochemistry, University of Kashmir)
  • Published : 2013.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir.

Keywords

References

  1. Arai H, Miyamoto K, Taketani Y, et al (1997). A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res, 12, 915-21. https://doi.org/10.1359/jbmr.1997.12.6.915
  2. Belov L, Zhou J, Christopherson RI (2011). Cell surface markers in colorectal cancer prognosis. Int J Mol Sci, 12, 78-113.
  3. Borek C (2004). Dietary antioxidants and human cancer. Integr Cancer Ther, 3, 333-41. https://doi.org/10.1177/1534735404270578
  4. Bretherton-Watt D, Given-Wilson R, Mansi JL (2001). Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Br J Cancer, 85, 171-5. https://doi.org/10.1054/bjoc.2001.1864
  5. Chakravarti AK (1974). Regional preferences for food: some aspects of food patterns in India. Can Geogr, 18, 395-410. https://doi.org/10.1111/j.1541-0064.1974.tb00212.x
  6. Chiu KC, Chuang LM, Yoon C (2001). The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet, 2, 2.
  7. Chokkalingam AP, McGlynn KA, Gao YT, et al (2001). Vitamin D receptor gene polymorphisms, insulin-like growth factors and prostate cancer risk: a population-based case-control study in China. Cancer Res, 61, 4333-6.
  8. Correa-Cerro L, Berthon P, Haussler J (1999). Vitamin D receptor polymorphisms as markers in prostate cancer. Hum Genet, 105, 281-7. https://doi.org/10.1007/s004390051102
  9. Curran JE, Vaughan T, Lea RA, et al (1999). Association of a vitamin D receptor polymorphism with sporadic breast cancer development. Int J Cancer, 83, 723-26. https://doi.org/10.1002/(SICI)1097-0215(19991210)83:6<723::AID-IJC4>3.0.CO;2-3
  10. Dar NA, Bhat GA, Shah IA, et al (2012). Hookah smoking, nass chewing and oesophageal cell carcinoma in Kashmir, India. Br J Cancer, 107, 1618-23. https://doi.org/10.1038/bjc.2012.449
  11. Feinberg AP, Vogelstein B (1987). Alterations in DNA methylation in human colon neoplasia. Semin Surg Oncol, 3, 149-51. https://doi.org/10.1002/ssu.2980030304
  12. Giovannucci E (2005). The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control, 16, 83-95. https://doi.org/10.1007/s10552-004-1661-4
  13. Gross C, Krishnan AV, Malloy PJ, et al (1998). The vitamin D receptor gene start codon polymorphism: a functional analysis of Fok I variants. J Bone Miner Res, 13, 1691-9. https://doi.org/10.1359/jbmr.1998.13.11.1691
  14. Haussler MR, Whitfield GK, Haussler CA, et al (1998). The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res, 13, 325-49. https://doi.org/10.1359/jbmr.1998.13.3.325
  15. Hubner RA, Muir KR, Liu JF, et al (2008). Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence. Int J Cancer, 123, 586-93. https://doi.org/10.1002/ijc.23536
  16. Hussain SMY, Thakur N, Salam I, et al (2011). Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley-a high risk area. Mol Carcinog, 50, 487-98. https://doi.org/10.1002/mc.20732
  17. Ingles SA, Garcia DG, Wang W, Nieters A (2000). Vitamin D receptor genotype and breast cancer in Latinas (United States). Cancer Causes Control, 11, 25-30. https://doi.org/10.1023/A:1008979417618
  18. Javid G, Zargar SA, Rather S, et al (2011). Incidence of colorectal cancer in Kashmir valley, India. Indian J Gastroenterol, 30, 7-11 https://doi.org/10.1007/s12664-010-0071-7
  19. Jurutka PW, Remus LS, Whitfield GK, et al (2000). The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol, 14, 401-20. https://doi.org/10.1210/mend.14.3.0435
  20. Kadiyska T, Yakulov T, Kaneva R, et al (2007). Vitamin D and estrogen receptor gene polymorphisms and the risk of colorectal cancer in Bulgaria. Int J Colorectal Dis, 22, 395-400. https://doi.org/10.1007/s00384-006-0163-0
  21. Kostner KIM, Denzer N, Muller CSL, et al (2009). The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res, 29, 3511-36.
  22. Kovacic P, Jacintho JD (2001). Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr Med Chem, 8, 773-96. https://doi.org/10.2174/0929867013373084
  23. Lamprecht SA, Lipkin M (2001). Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal carcinogenesis. Ann NY Acad Sci, 952, 73-87.
  24. Malecki MT, Frey J, Moczulski D, et al (2003). Vitamin D receptor gene polymorphisms and association with type 2 diabetes mellitus in a Polish population. Exp Clin Endocrinol Diabetes, 111, 505-9. https://doi.org/10.1055/s-2003-44711
  25. Malik MA, Zargar SA, Mittal B (2011a). Role of the metalloproteinase-7 (181A>G) polymorphism in gastric cancer susceptibility: a case control study in Kashmir Valley. Asian Pac J Cancer Prev, 12, 73-6.
  26. Malik MA, Sharma K, Goel S, Zargar SA, Mittal B (2011b). Association of TP53 intron 3, 16 bp duplication polymorphism with esophageal and gastric cancer susceptibility in Kashmir Valley. Oncol Res, 19, 165-9. https://doi.org/10.3727/096504011X12935427587920
  27. Malik MA, Zargar SA, Mittal B (2011c). Role of NQO1 609C>T and NQO2-3423 G>A polymorphisms in susceptibility to gastric cancer in Kashmir Valley. DNA Cell Biol, 30, 297-303. https://doi.org/10.1089/dna.2010.1115
  28. McCullough ML, Bostick RM, Mayo TL (2009). Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer. Annu Rev Nutr, 29, 111-32. https://doi.org/10.1146/annurev-nutr-080508-141248
  29. Miyamoto K, Kesterson RA, Yamamoto H, et al (1997). Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol, 11, 1165-79. https://doi.org/10.1210/mend.11.8.9951
  30. Murtaza I, Mushtaq D, Margoob MA, et al (2006). A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley. World J Gastroenterol, 12, 4033-7.
  31. Neyestani TR, Djazayerya A, Shab-Bidar S, et al (2013). Vitamin D receptor Fok I polymorphism modulates diabetic host response to vitamin D intake. Diabetes Care, 36, 550-6. https://doi.org/10.2337/dc12-0919
  32. Ochs-Balcom HM, Cicek MS, Thompson CL, et al (2008). Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis, 29, 1788-93. https://doi.org/10.1093/carcin/bgn166
  33. O'Connell, JB, Maggard MA, Ko CY (2004). Colon cancer survival rates with the new American joint committee on cancer sixth edition staging. J Natl Cancer Inst, 96, 1420-5. https://doi.org/10.1093/jnci/djh275
  34. Park K, Woo M, Nam J, Kim JC (2006). Start codon polymorphisms in the vitamin D receptor and colorectal cancer risk. Cancer Lett, 237, 199-206. https://doi.org/10.1016/j.canlet.2005.05.048
  35. Rasool MT, Lone MM, Wani ML, et al (2012). Cancer in Kashmir, India: burden and pattern of disease. J Can Res Ther, 8, 243-6 https://doi.org/10.4103/0973-1482.98978
  36. Rasool S, Ganai BA, Kadla SA, et al (2011). The ECRG1 290Arg/Gln polymorphism is related to risk of esophageal squamous cell carcinoma in Kashmir. Asian Pac J Cancer Prev, 12, 265-9.
  37. Rasool S, Ganai BA, Sameer AS, Masood A (2012). Esophageal cancer: associated factors with special reference to the Kashmir Valley. Tumori, 98, 191-203.
  38. Siddiqi M, Tricker AR, Preussmann R (1988). The occurrence of preformed N-nitroso compounds in the food samples from a high risk area of esophageal cancer in Kashmir, India. Cancer Lett, 39, 37-43. https://doi.org/10.1016/0304-3835(88)90038-9
  39. Slattery ML, Wolff RK, Herrick JS, Caan BJ, Potter JD (2007). IL6 genotypes and colo and rectal cancer. Cancer Causes Control, 18, 1095-105. https://doi.org/10.1007/s10552-007-9049-x
  40. Tajouri L, Ovcaric M, Curtain R, et al (2005). Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. J Neurogenet, 19, 25-38. https://doi.org/10.1080/01677060590949692
  41. Timbo BB, Ross MP, McCarthy PV, Lin CT (2006). Dietary supplements in a national survey: prevalence of use and reports of adverse events. J Am Diet Assoc, 106, 1966-74. https://doi.org/10.1016/j.jada.2006.09.002
  42. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004). Genetics and biology of vitamin D receptor polymorphisms. Gene, 338, 143-56. https://doi.org/10.1016/j.gene.2004.05.014
  43. Whitfield GK, Remus LS, Jurutka PW, et al (2001). Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol, 177, 145-59. https://doi.org/10.1016/S0303-7207(01)00406-3
  44. Wong HL, Seow A, Arakawa K, et al (2003). Vitamin D receptor start codon polymorphism and colorectal cancer risk: effect modification by dietary calcium and fat in Singapore Chinese. Carcinogenesis, 24, 1091-5. https://doi.org/10.1093/carcin/bgg059

Cited by

  1. Vitamin D Receptor BsmI Polymorphism and Colorectal Cancer Risk: an Updated Analysis vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.4801
  2. Association between Circulating Vitamin D, the Taq1 Vitamin D Receptor Gene Polymorphism and Colorectal Cancer Risk among Jordanians vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7337
  3. Genetic unraveling of colorectal cancer vol.35, pp.6, 2014, https://doi.org/10.1007/s13277-014-1713-7
  4. Associations between Vitamin D Receptor (VDR) Gene Polymorphisms and Colorectal Cancer Risk and Effect Modifications of Dietary Calcium and Vitamin D in a Japanese Population vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.2019
  5. Associations of Probiotics with Vitamin D and Leptin Receptors and their Effects on Colon Cancer vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3621
  6. Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia vol.20, pp.2, 2015, https://doi.org/10.15430/JCP.2015.20.2.97
  7. gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis vol.39, pp.10, 2017, https://doi.org/10.1177/1010428317727164
  8. Positive correlation between vitamin D receptor gene FokI polymorphism and colorectal cancer susceptibility in South-Khorasan of Iran vol.119, pp.10, 2018, https://doi.org/10.1002/jcb.26826
  9. Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-31244-5