DOI QR코드

DOI QR Code

No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

  • Sun, Yan (Departments of Chemotherapy, Zhejiang Cancer Hospital) ;
  • Zhang, Yong-Jun (Departments of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital) ;
  • Kong, Xiang-Ming (Departments of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital)
  • 발행 : 2013.09.30

초록

Background: This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls. Conclusions: Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.

키워드

참고문헌

  1. Broderick P, Wang Y, Vijayakrishnan J, et al (2009). Deciphering the impact of common genetic variation on lung cancer risk: A genome-wide association study. Cancer Res, 69, 6633-41. https://doi.org/10.1158/0008-5472.CAN-09-0680
  2. Campalans A, Marsin S, Nakabeppu Y, et al (2005). XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair. DNA Repair (Amst), 4, 826-35. https://doi.org/10.1016/j.dnarep.2005.04.014
  3. Carbonnelle E, Mesquita C, Bille E, et al (2011). MALDI-TOF mass sepectrometry tools for bacterial identification in clinical microbiology laboratory. Clin Biochem, 44, 104-9. https://doi.org/10.1016/j.clinbiochem.2010.06.017
  4. Chang JS, Wrensch MR, Hansen HM, et al (2009). Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. Carcinogenesis, 30, 78-87. https://doi.org/10.1093/carcin/bgn261
  5. Huang MY, Huang ML, Chen MJ, et al (2011). Multiple genetic polymorphisms in the prediction of clinical outcome of metastatic colorectal cancer patients treated with first-line FOLFOX-4 chemotherapy. Pharmacogenet Genomics, 21, 18-25. https://doi.org/10.1097/FPC.0b013e3283415124
  6. Hoeijmakers JH (2001). Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-74. https://doi.org/10.1038/35077232
  7. Horgan AM, Yang B, Azad AK, et al (2011). Pharmacogenetic and germline prognostic markers of lung cancer. J Thorac Onco, l6, 296-304.
  8. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2004). Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum, 83, 1-1438.
  9. James MA, Wen W, Wang Y, et al (2012). Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PLoS One, 7, e36116. https://doi.org/10.1371/journal.pone.0036116
  10. Jemal A, Siegel R, Ward E, et al (2009). Cancer statistics, 2009. CA Cancer J Clin, 59, 225-49. https://doi.org/10.3322/caac.20006
  11. Kim IS, Lee GW, Kim DC, et al (2010). Polymorphisms and haplotypes in the XRCC1 gene and the risk of advanced non-small cell lung cancer. J Thorac Oncol, 5, 1912-21. https://doi.org/10.1097/JTO.0b013e3181f46708
  12. Lindahl T, Wood RD (1999). Quality control by DNA repair. Science, 286, 1897-905. https://doi.org/10.1126/science.286.5446.1897
  13. Liu P, Vikis HG, Lu Y, et al (2010). Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. Cancer Epidemiol Biomarkers Prev, 19, 517-24. https://doi.org/10.1158/1055-9965.EPI-09-0791
  14. Mahimkar MB, Samant TA, Kannan S, et al (2012). Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy. Mol Carcinog, 5, E94-103.
  15. McKay JD, Hung RJ, Gaborieau V, et al (2008). Lung cancer susceptibility locus at 5p15.33. Nat Genet, 40, 1404-6. https://doi.org/10.1038/ng.254
  16. Pande M, Spitz MR, Wu X, et al (2011). Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. Carcinogenesis, 32, 1493-9. https://doi.org/10.1093/carcin/bgr136
  17. Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  18. Qian J, Massion PP (2008). Role of chromosome 3q amplification in lung cancer. J Thorac Oncol, 3, 212-5. https://doi.org/10.1097/JTO.0b013e3181663544
  19. Rafnar T, Sulem P, Stacey SN, et al (2009). Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet, 41, 221-7. https://doi.org/10.1038/ng.296
  20. Wang Y, Broderick P, Matakidou A, et al (2010). Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5- CHRNA3) variation and lung cancer risk in never-smokers. Carcinogenesis, 31, 234-8. https://doi.org/10.1093/carcin/bgp287
  21. Wang Y, Broderick P, Webb E, et al (2008). Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet, 40, 1407-9. https://doi.org/10.1038/ng.273
  22. Weaver DA, Crawford EL, Warner KA, et al (2005). ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines. Mol Cancer, 4,18. https://doi.org/10.1186/1476-4598-4-18
  23. Wu J, Liu J, Zhou Y, et al (2012). Predictive value of XRCC1 gene polymorphisms on platinum-based chemotherapy in advanced non-small cell lung cancer patients: a systematic review and meta-analysis. Clin Cancer Res, 18, 3972-81. https://doi.org/10.1158/1078-0432.CCR-11-1531
  24. Yamamoto K, Okamoto A, Isonishi S, et al (2001). A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. Biochem Biophys Res Commun, 280, 1148-54. https://doi.org/10.1006/bbrc.2001.4250
  25. Zhu G, Lippard SJ (2009). Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-links. Biochemistry, 48, 4916-25. https://doi.org/10.1021/bi900389b
  26. Zienolddiny S, Skaug V, Landvik NE, et al. (2009). The TERTCLPTM1L lung cancer susceptibility variant associates with higher DNA adducts formation in the lung. Carcinogenesis, 30, 1368-71. https://doi.org/10.1093/carcin/bgp131

피인용 문헌

  1. genes and risks of non-small cell lung cancer in East Chinese Han population vol.10, pp.3, 2014, https://doi.org/10.1111/crj.12218
  2. Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India vol.15, pp.5, 2014, https://doi.org/10.7314/APJCP.2014.15.5.1993
  3. Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population vol.15, pp.6, 2014, https://doi.org/10.7314/APJCP.2014.15.6.2809
  4. Association of the XRCC1 c.1178G>A Genetic Polymorphism with Lung Cancer Risk in Chinese vol.15, pp.9, 2014, https://doi.org/10.7314/APJCP.2014.15.9.4095
  5. The relationship between genetic variants of XRCC1 gene and lung cancer susceptibility in Chinese Han population vol.31, pp.9, 2014, https://doi.org/10.1007/s12032-014-0157-7
  6. The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population vol.35, pp.6, 2014, https://doi.org/10.1007/s13277-014-1702-x
  7. Association between CLPTM1L-TERT rs401681 polymorphism and pancreatic cancer risk among Chinese Han population vol.35, pp.6, 2014, https://doi.org/10.1007/s13277-014-1711-9
  8. Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China vol.12, pp.5, 2017, https://doi.org/10.1371/journal.pone.0177504