Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Formulation of Liquid Choline Alphoscerate as a Solid Dosage Form

액상 콜린알포세레이트의 고형 제제화 연구

  • Choi, Sung-Up (Department of Food Science and Biotechnology, Dongnam Health College) ;
  • Cho, Seong-Wan (Department of Pharmaceutics & Biotechnology, Medical Engineering College, Konyang University)
  • 최성업 (동남보건대학교 식품생명과학과) ;
  • 조성완 (건양대학교 의료공과대학 제약생명공학과)
  • Received : 2012.11.04
  • Accepted : 2013.12.05
  • Published : 2013.12.31
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Abstract

The aim of this study was to prepare and evaluate tablets containing liquid choline alphoscerate, which is capable of being formulated as a solid dosage form by the adsorption of magnesium aluminum silicate. The tablets were prepared with various absorbent to choine alphoscerate ratios. The physical properties and the dissolution rate were investigated. Considering the tabletting and dissolution rate, the formula scontaining 50-75% absorbent were adequate in the tested formulations. The 62.5% absorbent formula showed superior results with the tests of hardness, friability, disintegration time, and the ratio of dissolution area under the curve. Overall, magnesium aluminum silicate can be an alternative additive to a liquid drug.

본 연구에서는 액상 형태인 콜린알포세레이트를 알루미늄마그네슘규산화합물에 흡착시켜 고형의 제형화가 가능한 콜린알포세레이트를 함유하는 정제의 제조하고 평가하였다. 정제는 콜린알포세레이트 대비 흡착제의 비율을 달리하여 제조하고, 물리적 특성 및 용출률을 조사하였다. 정제의 타정성과 용출률을 고려할 때 흡착제는 주성분 대비 50~75%가 적절하였다. 주성분 대비 62.5%의 흡착제를 사용한 제제에서 정제의 경도, 붕해, 마손도 시험, 용출곡선하면적 비율 결과가 가장 우수하였다. 알루미늄마스네슘규산화합물은 액상 약물의 고형화 설계 시 좋은 소재가 될 수 있을 것이다.

Keywords

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