대한물리의학회지 (Journal of the Korean Society of Physical Medicine)

  • 제8권4호
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  • Pages.539-547
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  • 2013
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  • 1975-311X(pISSN)
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  • 2287-7215(eISSN)
대한물리의학회 (The Korean Society of Physical Medicine)
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다양한 운동 강도가 골관절염 흰쥐의 척수 내 TNF-α 발현에 미치는 영향

The Effects of Exercise of Diverse Intensities on the Expression of TNF-α in the Spinal Cord in Osteoarthritic Rats

  • 박수진 (경성대학교 이과대학 물리치료학과)
  • Park, Soo-Jin (Department of Physical Therapy, College of Science, Kyungsung University)
  • 투고 : 2013.08.08
  • 심사 : 2013.09.05
  • 발행 : 2013.11.30
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초록

PURPOSE: This study examined the effects of exercise of diverse intensities on the expression of TNF-${\alpha}$(tumor necrosis factor-${\alpha}$) in the spinal cord in osteoarthritic rats. METHODS: Over a period of four weeks, the authors applied treadmill exercise programs of diverse intensities to Sprague-Dawley rats, to which intra-articular injection of monosodium iodoacetate(MIA, $3mg/50{\mu}l$, diluted in saline) was applied to the right knee joint to induce osteoarthritis. The four-week exercise program was not carried out with the control group(CG, n=10). Exercise programs of applicable intensities were applied to the low-intensity exercise group(LEG, n=10), moderate-intensity exercise group (MEG, n=10), and high-intensity exercise group(HEG, n=10) over the four weeks. Observations were made of expression of TNF-${\alpha}$ in the spinal cord in osteoarthritic rats using western blot analysis. RESULT: there were significant differences(p<.05) in the comparison of expression of TNF-${\alpha}$ between the four groups involved. The expression of TNF-${\alpha}$ in the spinal cord, the LEG and HEG had more elevated expression significantly than the CG(p<.05). But the MEG had reduced expression significantly than the CG(p<.05). CONCLUSION: These study results suggest that moderate-intensity exercise is effective in inhibition TNF-${\alpha}$ in the spinal cord. They also indicate that in prescribing exercise to treat osteoarthritic patients, exercise of moderate intensity is most suitable to patients' chronic pain, rather than low or high intensity.

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