Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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Impedance Changes of Living Tissue During Radiation Exposure Dose

방사선 피폭선량에 대한 생체 조직의 임피던스 변화

  • Kil, Sang Hyeong (Department of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Lee, Moo Seok (Department of Nuclear Medicine, Pusan National University Hospital) ;
  • Nam, Ji Ho (Department of Radiation Oncology, Pusan National University Yangsan Hospital) ;
  • Lee, Yeong Hwa (Department of Radiation Oncology, Pusan National University Yangsan Hospital) ;
  • Kim, Gun Do (Department of Microbiology, Pukyong National University) ;
  • Lee, Jong Kyu (Department of Physics, Pukyong National University)
  • 길상형 (양산부산대학교병원 핵의학과) ;
  • 이무석 (부산대학교병원 핵의학과) ;
  • 남지호 (양산부산대학교병원 방사선종양학과) ;
  • 이영화 (양산부산대학교병원 방사선종양학과) ;
  • 김군도 (부경대학교 미생물학과) ;
  • 이종규 (부경대학교 물리학과)
  • Received : 2013.09.09
  • Accepted : 2013.10.17
  • Published : 2013.12.30
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Abstract

Bioimpedance involves a lot of information related to living tissue. If there is alteration in bio tissue, its electrical characteristics also change. It is to study electrical characteristics of pork tenderlion in using a HP-4194A Impedance/Gain-phase analyzer instrument and electrical characteristics changes by graded radiation exposure dose. The results were as follow 1. Electrical characteristics of pork tenderlion in repeated measurement had high precision within ${\pm}5$% of coefficiency of variability. 2. During the measurement impedance absolute value and phase alteration did not show statistically significant difference.(p>0.05) 3. While impedance phase of electrical characteristics associated with frequency change was almost stable, impedance absolute value was in inverse proportion to frequency that means high inverse correlation of -0.096(r). 4. Impedance absolute value dropped in radiation exposure dose. The alteration of the value did not show statistically significant difference in 1 Gy, 2 Gy and 4 Gy.(p>0.05) However in radiation exposure dose of 10 Gy, the decrease of impedance absolute value was significantly different.(p<0.05) 5. Impedance phase according to radiation exposure dose change did not show statistically significant difference in 1 Gy, 2 Gy, 4 Gy, and 10 Gy(p>0.05).

생체 조직의 전기 신호는 살아 있는 조직과 관련된 많은 정보를 포함하고 있으며, 생체 조직에 생물학적 변화가 있으면 고유의 전기적 특성이 변화한다. Impedance/Gain-phase analyzer로 1 KHz에서 1 KHz까지 주파수 대역을 설정한 다음 교류 주파수를 인가하며 돼지안심 조직의 임피던스 특성을 방사선 피폭선량에 따라 변화가 있는지 알아보고자 하였다. 임피던스 크기는 주파수에 비례하여 감소하였으며, 상관계수(r)가 -0.96으로 높은 음의 상관관계를 보였다. 위상차 변화는 거의 없었으며 조직은 저항성을 나타내었다. 측정값은 변동계수가 ${\pm}5$%이내로 재현성이 있음을 알 수 있었고, 측정 시간 경과에 따른 임피던스 크기와 위상차 변화는 유의적인 차이가 없었다.(p>0.05) 방사선 피폭 시 임피던스 변화는 대조군과 비교했을 때 1 Gy, 2 Gy, 4 Gy 피폭 선량에서는 임피던스 크기는 감소하였으나, 유의적인 차이는 없었다.(p>0.05) 그러나 10 Gy 피폭 선량에서는 임피던스 크기 감소가 유의적으로 나타났다.(p<0.05) 방사선 피폭선량이 증가하여도 위상차 변화는 거의 없었으며, 대조군과 비교했을 때 1 Gy, 2 Gy, 4 Gy, 10 Gy 모두 유의적인 차이가 없었다.(p>0.05) 본 연구를 통해 생체 조직의 전기적 특성을 이해 할 수 있었고, 방사선 피폭선량에 따른 임피던스 변화를 측정하여 방사선이 인체에 미치는 영향을 직접 평가 할 수 있는 가능성을 확인 할 수 있었다.

Keywords

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