Elevation of Plasma NT-proBNP Concentration in a Korean Jindo Dog Infected with Dirofilaria immitis

심장사상충 감염 진도견에서 혈장 NT-proBNP 농도 증가 증례

  • Hwang, Soo-Hyen (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Park, Hyung-Jin (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung-Won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Sang-Eun (Division of Malaria & Parasitic Diseases, Korea National Institute of Health, Korea Centers for Disease Control and Prevention) ;
  • Song, Kun-Ho (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
  • Accepted : 2013.11.20
  • Published : 2013.12.31

Abstract

The aim of this study is to report the observed elevation of plasma N-terminal pro-B-type natriuretic peptide (NT proBNP) concentration in a Korean Jindo Dog infected with Dirofilaria immitis. Evaluation of the animal included physical examination, thoracic radiography, ELISA kit ($PetCheck^{(R)}$, IDEXX Laboratories, USA) test and plasma NT-proBNP evaluation. The infected animal's NT-proBNP concentration was compared with those of 5 normal dogs of the same age, sex, and breed; the affected Korean Jindo dog had increased plasma NT-proBNP. To the best our knowledge, this is the first report of NT-proBNP elevation in a Korean Jindo dog with dirofilariasis.

본 증례는 충남대학교 수의과대학 부속동물병원에 내원한 심장사상충에 중감염된 2세, 암컷의 진도견에서 혈장 NT-pro BNP농도를 측정하였다. 심장사상충 감염은 신체검사, 혈액검사, ELISA 키트검사 및 영상진단검사 등으로 진단하였다. 본 증례 진도견의 혈장 NT-pro BNP농도는 심장사상충에 감염되지 않고, 다른 질병도 없는 5마리(모두2세, 모두 암컷)의 정상견과 비교하였을 때, 상대적으로 매우 높은 수치를 나타내었다 (정상견 평균: 373 pmol/L, 본 증례: 2,950 pmol/L). 본 연구는 우리가 아는 한 심장사상충에 감염된 진도견에서 혈장 NT-pro BNP농도를 측정하여 보고한 최초의 증례보고이다.

Keywords

References

  1. Atkins CE. Heartworm disease: An update. Vet Med 1998; 93: 2-18.
  2. Bandi C, Trees AJ, Brattig NW. Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases. Vet Parasitol 2001; 198: 215-238.
  3. Caryn R, Mark O. Biomarkers in the diagnosis of canine heart disease. Vet Focus 2008; 18: 2-7.
  4. Grandjean D. The royal canin dog encyclopedia. Paris: Aniwa Publishing. 2001; 178-179.
  5. Hassdenteufel E, Kresken JG, Henrich E, Hildebrandt N, Schneider C, Stosic A, Schneider M. NT-proBNP as a diagnostic marker in dogs with dyspnea and in asymptomatic dogs with heart murmur. Tierarztl Prax Ausg K Kleintiere Heimtiere 2012; 40: 171-179.
  6. Kellihan H, Oyama M, Reynolds C, Stepien RL. Weekly variability of plasma and serum NT- proBNP measurements in normal dogs. J Vet Cardiol 2009; 111: 93-97.
  7. Lee SG, Hyun C. Evaluation of plasma NT-proBNP concentration in dogs with chronic mitral valve insufficiency. J Vet Clin 2013; 30: 151-158.
  8. McCall JW, Genchi C, Kramer LH, Guerrero J, Venco L. Heartworm disease in animals and humans. Adv Parasitol 2008; 66: 193-285. https://doi.org/10.1016/S0065-308X(08)00204-2
  9. Nelson RW, Couto CG. Small Animal Internal Medicine. 4th ed. St. Louis, USA. Mosby Elsevier, 2009; 169-183.
  10. Oyama MA, Rush JE, Rozanski EA, Fox PR, Reynolds CA, Gordon SG, Bulmer BJ, Lefbom BK, Brown BA, Lehmkuhl LB, Prosek R, Lesser MB, Kraus MS, Bossbaly MJ, Rapoport GS, Boileau JS. Assessment of serum N-terminal pro-Btype natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dgos. JAVMA 2009; 235: 1319-1325. https://doi.org/10.2460/javma.235.11.1319
  11. Song KH, Lee SE, Hayasaki M, Shiramizu K, Kim DH, Cho KW. Seroprevalence of canine dirofilariosis in South Korea. Vet Parasitol 2003; 114: 195-198. https://doi.org/10.1016/S0304-4017(03)00142-0
  12. Song KH, Park JE, Lee DH, Lee SH, Shin HJ. Serological update and molecular characterization of Dirofilaria immitis in dogs, South Korea. Res Vet Sci 2010; 88: 467-469. https://doi.org/10.1016/j.rvsc.2009.10.007