Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제39권6호
  • /
  • Pages.292-296
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  • 2013
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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Verruciform xanthoma of the palatal gingiva: a report of two cases

  • Ryu, Da Jung (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, College of Dentistry, Yonsei University) ;
  • Lee, Sang Hoon (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, College of Dentistry, Yonsei University) ;
  • Yuk, Jong In (Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University) ;
  • Kim, Hyung Jun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Huh, Joing-Ki (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, College of Dentistry, Yonsei University) ;
  • Park, Kwang-Ho (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, College of Dentistry, Yonsei University)
  • 투고 : 2013.08.12
  • 심사 : 2013.09.26
  • 발행 : 2013.12.31
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초록

Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has indistinct clinical features, making histopathological examination necessary for a definitive diagnosis. Histologically, VX is characterized by parakeratosis, rete ridges with uniform depth, and an accumulation of the foam cells, which are also known as the "xanthoma cells". These foam cells test positive for antibodies, such as CD-68 and vimentin; it is thought that VX foam cells are derived from the monocyte-macrophage lineage, and that VX's pathogenic mechanism is partly related to an immune mechanism. Nevertheless, the pathogenesis of VX remains unclear. VX can be treated by surgical excision; other medical, chemical, and radiological treatments are not required postoperatively. Recurrence and malignant transformation of VX are rare. Two patients, each with a mass of unknown origin on the palatal gingiva, were presented at our clinic. Excisional biopsies of the masses were performed for a histological diagnosis after clinical and radiological examinations. Histological examination confirmed a diagnosis of VX in both cases.

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참고문헌

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