Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
권호 표지

Analysis of Main Single Medicinal Herbs for Anti-Obesity Miyoung Song, Hojun Kim Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University Received: November

비만에 작용하는 주요 본초의 항비만 효과 분석

  • Song, Miyoung (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk Univer) ;
  • Kim, Hojun (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk Univer)
  • 송미영 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학과교실)
  • Received : 2013.11.11
  • Accepted : 2013.11.26
  • Published : 2013.12.30
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Abstract

Objectives: This study was conducted to analyze anti-obesity effects of the main single medicinal herbs which have effects on obesity or metabolic syndrome. Methods: We selected the 8 main single medicinal herbs, and then 3 databases were searched using search words "obesity", and "each scientific name of selected 8 main herbs". Results and Conclusions: Only Ephedra sinica and Panax ginseng were analyzed through 3 methods, in vitro, animal studies and randomized controlled trial (RCT)s, Ephedra sinica was shown weight loss effects in RCTs, but Panax ginseng couldn't. Other 6 selected medicinal herbs were not verified in RCTs, all had anti-obesity effects in high fat fed mice (or rats) and the others except for Radix notoginseng and Radix puerariae had inhibitory effects on lipid accumulation in 3T3-L1 cells.

Keywords

References

  1. KNHANES. Health behaviors and chronic disease statistics, 2010. Available from: http://knhanes.cdc.go.kr/knhanes/sub04/ sub04_03.do?pageNo=1&classType=7.
  2. Soon JY. Pharmacological treatment of obesity. J Korean Soc Endocrinol. 2008 ; 23 : 223-33. https://doi.org/10.3803/jkes.2008.23.4.223
  3. KFDA. Available from: http://www.kfda.go.kr/antidrug/index. do?nMenuCode.
  4. Hwang MJ, Shin HD, Song MY. Literature review of herbal medicines on treatment of obesity since 2000 - mainly about ephedra herba. J Korean Med Obes Res. 2007 ; 7 : 39-54.
  5. Park JH, Lee MJ, Song MY, Bose S, Shin BC, Kim HJ. Efficacy and safety of mixed oriental herbal medicines for treating human obesity: a systematic review of randomized clinical trials. J Med Food. 2012 ; 15(7) : 589-97. https://doi.org/10.1089/jmf.2011.1982
  6. Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets. 2008 ; 8(2) : 99-111. https://doi.org/10.2174/187153008784534330
  7. Hasani-Ranjbar S, Nayebi N, Larijani B, Abdollahi M. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World J Gastroenterol. 2009 ; 15(25) : 3073-85. https://doi.org/10.3748/wjg.15.3073
  8. Kim SB. The effects of proliferation and differentiation on adipocyte 3T3-L1 by prescriptions and herbs of Tae-yang In and Tae-um In. Doctor's degree. Seoul: Kyung Hee University. 1998.
  9. Shin YJ. The effects of fermentated Mahuang(Ephedra sinica) on obese fats fed by high fat diet. Doctor's degree. Gyeongju: Dongguk University. 2009.
  10. Song MK, Um JY, Jang HJ, Lee BC. Beneficial effect of dietary Ephedra sinica on obesity and glucose intolerance in high-fat diet-fed mice. Exp Ther Med. 2012 ; 3(4) : 707-12. https://doi.org/10.3892/etm.2012.462
  11. Song MK. The effects of Ephedrae herba on obese type 2 diabetes mouse model induced by high fat, high carbonate diet. Master's degree. Seoul: Kyung Hee University. 2009.
  12. Kim YJ. The effects of Ephedra sinica on lipid of blood serum and epididymis fat cells in the rats. Master's degree, Gyeongju: Dongguk University. 2006.
  13. Lee YJ. The efficiency of Ephedrae herba on the obese zucker rats' lipid of blood serum and fatty acid metabolism of skeletal muscles. Master's degree. Gyeongju: Dongguk University. 2005.
  14. Kim HJ, Park JM, Kim JA, Ko BP. Effect of herbal Ephedra sinica and Evodia rutaecarpa on body composition and resting metabolic rate: a randomized, double-blind clinical trial in Korean premenopausal women. J Acupunct Meridian Stud. 2008 ; 1(2) : 128-38. https://doi.org/10.1016/S2005-2901(09)60033-9
  15. Oh J, Lee H, Park D, Ahn J, Shin SS, Yoon M. Ginseng and its active components ginsenosides inhibit adipogenesis in 3T3-L1 cells by regulating MMP-2 and MMP-9. Evid Based Complement Alternat Med. 2012 ; 2012 : 1-14.
  16. Lee HJ, Lee YH, Park SK, Kang ES, Kim HJ, Lee YC, et al. Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism. 2009 ; 58(8) : 1170-7. https://doi.org/10.1016/j.metabol.2009.03.015
  17. Lee YS, Cha BY, Yamaguchi K, Choi SS, Yonezawa T, Teruya T, et al. Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice. Cytotechnology. 2010 ; 62(4) : 367-76. https://doi.org/10.1007/s10616-010-9288-7
  18. Lee H, Park D, Yoon M. Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat dietinduced obese C57BL/6J mice. Food Chem Toxicol. 2013 ; 53 : 402-8. https://doi.org/10.1016/j.fct.2012.11.052
  19. Lee SH, Lee HJ, Lee YH, Lee BW, Cha BS, Kang ES, et al. Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. Phytother Res. 2012 ; 26(1) : 142-7. https://doi.org/10.1002/ptr.3610
  20. Mollah ML, Kim GS, Moon HK, Chung SK, Cheon YP, Kim JK, et al. Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice. Phytother Res. 2009 ; 23(2) : 220-5. https://doi.org/10.1002/ptr.2593
  21. Kwon DH, Bose S, Song MY, Lee MJ, Lim CY, Kwon BS, et al. Efficacy of Korean red ginseng by single nucleotide polymorphism in obese women: randomized, double-blind, placebo-controlled trial. J Ginseng Res. 2012 ; 36(2) : 176-89. https://doi.org/10.5142/jgr.2012.36.2.176
  22. Cho YH, Ahn SC, Lee SY, Jeong DW, Choi EJ, Kim YJ, et al. Effect of Korean red ginseng on insulin sensitivity in nondiabetic healthy overweight and obese adults. Asia Pac J Clin Nutr. 2013 ; 22(3) : 365-71.
  23. Gal SW, Choi YJ, Cho SJ. Anti-obesity effect of crataegus fructus extract from Chinese cultivation. J Life Sci. 2011 ; 21(11) : 1686-91.
  24. Kuo DH, Yeh CH, Shieh PC, Cheng KC, Chen FA, Cheng JT. Effect of shanzha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet. J Ethnopharmacol. 2009; 124(3) : 544-50. https://doi.org/10.1016/j.jep.2009.05.005
  25. Bas SS, Yoon HD, Shin OC, Shin YJ, Park CS, Park JH, et al. The effects of Artemisiae capillaris, Ponciri fructus and Cartaegi fructus in obese rats induced by high fat diet. Korean J Herbology. 2006 ; 21(3) : 55-67.
  26. Hong CR. Inhibitory effect of Cori fructus ethanolic extracts on adipogenesis in 3T3-L1 preadipocytes. Master's degree. Incheon: Inha University. 2009.
  27. Jayaprakasam B, Olson LK, Schutzki RE, Tai MH, Nair MG. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem. 2006 ; 54(1) : 243-8. https://doi.org/10.1021/jf0520342
  28. Hwang EY, Hong JH, Choi JH, Lee EJ, Lee IS. Study on anti-obesity and hypoglycemic effects of Lycium chinense mill extracts. J Korean Soc Food Sci Nutr. 2009 ; 11(38) : 1528-34.
  29. Song YS, Effects of Bangkihwangkitang, Bangkihwangkitang with Lycii fructus and Lycii fructus on the weight of obese rats. Wonkwanghanihak. 1992 ; 2(1) : 102-20.
  30. Kim JJ, Xiao H, Tan Y, Wang ZZ, Paul Seale J, Qu X. The effects and mechanism of saponins of Panax notoginseng on glucose metabolism in 3T3-L1 cells. Am J Chin Med. 2009 ; 37(6) : 1179-89. https://doi.org/10.1142/S0192415X09007582
  31. Lee DH. The effects of Panax notoginseng on high fat and high carbohydrate diet-induced obese diabetic mouse model. Doctor's degree, Naju: Dongshin University. 2012.
  32. Xia W, Sun C, Zhao Y, Wu L. Hypolipidemic and antioxidant activities of sanchi (radix notoginseng) in rats fed with a high fat diet. Phytomedicine. 2011 ; 18(6) : 516-20. https://doi.org/10.1016/j.phymed.2010.09.007
  33. Yang CY, Xie ZG, Cheng WB, Jiang X, Chen ZH. Effects of Panax notoginseng saponins on anti-hyperglycemic, anti-obese and prevention from kidney pathological changes in KK-Ay mice. Zhong Yao Cai. 2009 ; 32(10) : 1571-6.
  34. Lee CE, Hur HJ, Hwang JT, Sung MJ, Yang HJ, Kim HJ, et al. Long-term consumption of Platycodi radix ameliorates obesity and Insulin Resistance via the Activation of AMPK Pathways. Evid Based Complement Alternat Med. 2012 ; 2012 : 759143.
  35. Han LK, Xu BJ, Kimura Y, Zheng Yn, Okuda H. Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity. J Nutr. 2000 ; 130(11) : 2760-4. https://doi.org/10.1093/jn/130.11.2760
  36. Byun BH, Seo BI. Effect of Platycodi radix powder on enzyme activities of obese rats serum fed high fat diet. Korean J Herbology. 2003 ; 18(4) : 135-9.
  37. Xu ME, Xiao SZ, Sun YH, Zheng XX, Ou-Yang Y, Guan C. The study of anti-metabolic syndrome effect of puerarin in vitro. Life Sci. 2005 ; 77(25) : 3183-96. https://doi.org/10.1016/j.lfs.2005.03.036
  38. Lee OH, Seo DH, Park CS, Kim YC. Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. Biofactors. 2010 ; 36(6) : 459-67. https://doi.org/10.1002/biof.119
  39. Zhang W, Liu CQ, Wang PW, Sun SY, Su WJ, Zhang HJ, et al. Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. Eur J Pharmacol. 2010 ; 649(1-3) : 398-402. https://doi.org/10.1016/j.ejphar.2010.09.054
  40. Prasain JK, Peng N, Rajbhandari R, Wyss JM. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. Phytomedicine. 2012 ; 20(1) : 17-23. https://doi.org/10.1016/j.phymed.2012.09.017
  41. Shin HJ, Yoo JE, Jung EH, Yoo DY. Effects of Pueraria iobata body weight and gene expression in obese rats muscle with estrogen defieiency. J Orient Gynecol. 2012 ; 25(3) : 71-84.
  42. Shannon JR, Gottesdiener K, Jordan J, Chen K, Flattery S, Larson PJ, et al. Acute effect of ephedrine on 24-h energy balance. Clin Sci (Lond). 1999 ; 96(5) : 483-91. https://doi.org/10.1042/CS19980206
  43. Magkos F, Kavouras SA. Caffeine and ephedrine: physiological, metabolic and performance-enhancing effects. Sports Med. 2004 ; 34(13) : 871-89. https://doi.org/10.2165/00007256-200434130-00002
  44. Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, et al. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. JAMA. 2003 ; 289(12) : 1537-45.
  45. Kim DH. Chemical diversity of Panax ginseng, Panax quinquifolium and Panax notoginseng. J Ginseng Res. 2012 ; 6(1) : 1-15.
  46. Vuksan, V, Sung MK, Sievenpiper JL, Stavro PM, Jenkins AL, Di Buono M, et al. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebocontrolled study of efficacy and safety. Nutr Metab Cardiovasc Dis. 2006 ; 18(1) : 45-56.
  47. Uzayisenga R, Ayeka PA, Wang Y. Anti-diabetic potential of Panax notoginseng saponins (PNS): a review. Phytother Res. 2013. [Epub ahead of print]
  48. Zheng G, Zhang X, Zheng J, Meng Q, Zheng D. Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata. Zhong Yao Cai. 2002 ; 25(8) : 566-8.